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Published in: Insights into Imaging 1/2015

Open Access 01-02-2015 | Pictorial Review

Imaging spectrum of renal oncocytomas: a pictorial review with pathologic correlation

Authors: Kousei Ishigami, Aaron R. Jones, Laila Dahmoush, Leandro V. Leite, Marius G. Pakalniskis, Thomas J. Barloon

Published in: Insights into Imaging | Issue 1/2015

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Abstract

Objectives

The purpose of this pictorial review is to present the imaging spectrum of renal oncocytomas with radiological-pathological correlation.

Conclusion

The differences in tumour cellularity (high cellularity or low cellularity with abundant stroma) and haemorrhagic/cystic change contribute to a wide spectrum of imaging findings of renal oncocytomas. Imaging findings substantially overlap those of common subtypes of clear cell and non-clear cell renal cell carcinomas. Multifocal renal oncocytomas are not rare, and making the diagnosis of oncocytoma with concomitant renal cell carcinoma is difficult. In addition, renal oncocytomas that demonstrate interval growth or develop in the setting of end-stage renal disease may be mistaken for malignancy.

Teaching Points

High cellular components demonstrate avid arterial enhancement and subsequent washout.
Low cellular components demonstrate gradual subsequent enhancement owing to abundant stroma.
Cystic and hemorrhagic changes may account for lesion heterogeneity in the delayed phase.
Multifocal oncocytomas and oncocytomas coexisting with renal cell carcinoma are not rare.
Renal oncocytomas may demonstrate interval growth.
Literature
1.
go back to reference Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin PB et al (1997) Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol 21(8):871–883CrossRefPubMed Perez-Ordonez B, Hamed G, Campbell S, Erlandson RA, Russo P, Gaudin PB et al (1997) Renal oncocytoma: a clinicopathologic study of 70 cases. Am J Surg Pathol 21(8):871–883CrossRefPubMed
2.
go back to reference Gakis G, Kramer U, Schilling D, Kruck S, Stenzl A, Schlemmer HP (2011) Small renal oncocytomas: differentiation with multiphase CT. Eur J Radiol 80(2):274–278CrossRefPubMed Gakis G, Kramer U, Schilling D, Kruck S, Stenzl A, Schlemmer HP (2011) Small renal oncocytomas: differentiation with multiphase CT. Eur J Radiol 80(2):274–278CrossRefPubMed
3.
go back to reference Cornelis F, Lasserre AS, Tourdias T, Deminière C, Ferrière JM, Le Bras Y et al (2013) Combined late gadolinium-enhanced and double-echo chemical-shift MRI help to differentiate renal oncocytomas with high central T2 signal intensity from renal cell carcinomas. AJR Am J Roentgenol 200(4):830–838CrossRefPubMed Cornelis F, Lasserre AS, Tourdias T, Deminière C, Ferrière JM, Le Bras Y et al (2013) Combined late gadolinium-enhanced and double-echo chemical-shift MRI help to differentiate renal oncocytomas with high central T2 signal intensity from renal cell carcinomas. AJR Am J Roentgenol 200(4):830–838CrossRefPubMed
4.
go back to reference Chao DH, Zisman A, Pantuck AJ, Freedland SJ, Said JW, Belldegrun AS (2002) Changing concepts in the management of renal oncocytoma. Urology 59(5):635–642CrossRefPubMed Chao DH, Zisman A, Pantuck AJ, Freedland SJ, Said JW, Belldegrun AS (2002) Changing concepts in the management of renal oncocytoma. Urology 59(5):635–642CrossRefPubMed
5.
go back to reference Choudhary S, Rajesh A, Mayer NJ, Mulcahy KA, Haroon A (2009) Renal oncocytoma: CT features cannot reliably distinguish oncocytoma from other renal neoplasms. Clin Radiol 64(5):517–522CrossRefPubMed Choudhary S, Rajesh A, Mayer NJ, Mulcahy KA, Haroon A (2009) Renal oncocytoma: CT features cannot reliably distinguish oncocytoma from other renal neoplasms. Clin Radiol 64(5):517–522CrossRefPubMed
6.
go back to reference Kim JI, Cho JY, Moon KC, Lee HJ, Kim SH (2009) Segmental enhancement inversion at biphasic multidetector CT: characteristic finding of small renal oncocytoma. Radiology 252(2):441–448CrossRefPubMed Kim JI, Cho JY, Moon KC, Lee HJ, Kim SH (2009) Segmental enhancement inversion at biphasic multidetector CT: characteristic finding of small renal oncocytoma. Radiology 252(2):441–448CrossRefPubMed
7.
go back to reference Schieda N, McInnes MD, Cao L (2014) Diagnostic accuracy of segmental enhancement inversion for diagnosis of renal oncocytoma at biphasic contrast enhanced CT: systematic review. Eur Radiol 24(6):1421–1429CrossRefPubMed Schieda N, McInnes MD, Cao L (2014) Diagnostic accuracy of segmental enhancement inversion for diagnosis of renal oncocytoma at biphasic contrast enhanced CT: systematic review. Eur Radiol 24(6):1421–1429CrossRefPubMed
8.
go back to reference Millet I, Doyon FC, Hoa D, Thuret R, Merigeaud S, Serre I et al (2011) Characterization of small solid renal lesions: can benign and malignant tumors be differentiated with CT? AJR Am J Roentgenol 197(4):887–896CrossRefPubMed Millet I, Doyon FC, Hoa D, Thuret R, Merigeaud S, Serre I et al (2011) Characterization of small solid renal lesions: can benign and malignant tumors be differentiated with CT? AJR Am J Roentgenol 197(4):887–896CrossRefPubMed
9.
go back to reference O’Malley ME, Tran P, Hanbidge A, Rogalla P (2012) Small renal oncocytomas: is segmental enhancement inversion a characteristic finding at biphasic MDCT? AJR Am J Roentgenol 199(6):1312–1315CrossRefPubMed O’Malley ME, Tran P, Hanbidge A, Rogalla P (2012) Small renal oncocytomas: is segmental enhancement inversion a characteristic finding at biphasic MDCT? AJR Am J Roentgenol 199(6):1312–1315CrossRefPubMed
10.
go back to reference McGahan JP, Lamba R, Fisher J, Starshak P, Ramsamooj R, Fitzgerald E et al (2011) Is segmental enhancement inversion on enhanced biphasic MDCT a reliable sign for the noninvasive diagnosis of renal oncocytomas? AJR Am J Roentgenol 197(4):W674–W679CrossRefPubMed McGahan JP, Lamba R, Fisher J, Starshak P, Ramsamooj R, Fitzgerald E et al (2011) Is segmental enhancement inversion on enhanced biphasic MDCT a reliable sign for the noninvasive diagnosis of renal oncocytomas? AJR Am J Roentgenol 197(4):W674–W679CrossRefPubMed
11.
go back to reference Bird VG, Kanagarajah P, Morillo G, Caruso DJ, Ayyathurai R, Leveillee R et al (2011) Differentiation of oncocytoma and renal cell carcinoma in small renal masses (<4 cm): the role of 4-phase computerized tomography. World J Urol 29(6):787–792CrossRefPubMed Bird VG, Kanagarajah P, Morillo G, Caruso DJ, Ayyathurai R, Leveillee R et al (2011) Differentiation of oncocytoma and renal cell carcinoma in small renal masses (<4 cm): the role of 4-phase computerized tomography. World J Urol 29(6):787–792CrossRefPubMed
12.
go back to reference Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Raman SS (2013) Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT. Radiology 267(2):444–453CrossRefPubMed Young JR, Margolis D, Sauk S, Pantuck AJ, Sayre J, Raman SS (2013) Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT. Radiology 267(2):444–453CrossRefPubMed
13.
go back to reference Pierorazio PM, Hyams ES, Tsai S et al (2013) Multiphasic enhancement patterns of small renal masses (≤4 cm) on preoperative computed tomography: utility for distinguishing subtypes of renal cell carcinoma, angiomyolipoma, and oncocytoma. Urology 81(6):1265–1271CrossRefPubMed Pierorazio PM, Hyams ES, Tsai S et al (2013) Multiphasic enhancement patterns of small renal masses (≤4 cm) on preoperative computed tomography: utility for distinguishing subtypes of renal cell carcinoma, angiomyolipoma, and oncocytoma. Urology 81(6):1265–1271CrossRefPubMed
14.
go back to reference Zhang J, Lefkowitz RA, Ishill NM, Wang L, Moskowitz CS, Russo P et al (2007) Solid renal cortical tumors: differentiation with CT. Radiology 244(2):494–504CrossRefPubMed Zhang J, Lefkowitz RA, Ishill NM, Wang L, Moskowitz CS, Russo P et al (2007) Solid renal cortical tumors: differentiation with CT. Radiology 244(2):494–504CrossRefPubMed
15.
go back to reference Rosenkrantz AB, Hindman N, Fitzgerald EF, Niver BE, Melamed J, Babb JS (2010) MRI features of renal oncocytoma and chromophobe renal cell carcinoma. AJR Am J Roentgenol 195(6):W421–W427CrossRefPubMed Rosenkrantz AB, Hindman N, Fitzgerald EF, Niver BE, Melamed J, Babb JS (2010) MRI features of renal oncocytoma and chromophobe renal cell carcinoma. AJR Am J Roentgenol 195(6):W421–W427CrossRefPubMed
16.
go back to reference He W, Liu JY (2011) Characteristic finding of renal oncocytoma and clear-cell renal cell carcinoma with multiphase CT. Chin J Radiol 45:1203–1206 He W, Liu JY (2011) Characteristic finding of renal oncocytoma and clear-cell renal cell carcinoma with multiphase CT. Chin J Radiol 45:1203–1206
17.
go back to reference Woo S, Cho JY, Kim SH, Kim SY, Lee HJ, Hwang SI et al (2013) Segmental enhancement inversion of small renal oncocytoma: differences in prevalence according to tumor size. AJR Am J Roentgenol 200(5):1054–1059CrossRefPubMed Woo S, Cho JY, Kim SH, Kim SY, Lee HJ, Hwang SI et al (2013) Segmental enhancement inversion of small renal oncocytoma: differences in prevalence according to tumor size. AJR Am J Roentgenol 200(5):1054–1059CrossRefPubMed
18.
go back to reference Kodama K, Nagano K, Akimoto M, Suzuki S (2004) Small renal oncocytoma with central cystic degeneration. Int J Urol 11(2):110–113CrossRefPubMed Kodama K, Nagano K, Akimoto M, Suzuki S (2004) Small renal oncocytoma with central cystic degeneration. Int J Urol 11(2):110–113CrossRefPubMed
19.
go back to reference Porter KA (1992) The kidneys. In: Symmers WC (ed) Systemic pathology, 3rd edn. Churchill Livingstone, Edinburgh, pp 582–586 Porter KA (1992) The kidneys. In: Symmers WC (ed) Systemic pathology, 3rd edn. Churchill Livingstone, Edinburgh, pp 582–586
20.
go back to reference Leroy X, Aubert S, Lemaitre L, Haffner J, Biserte J, Gosselin B (2006) Multilocular cystic renal oncocytoma. J Clin Pathol 59(2):223–224PubMedCentralPubMed Leroy X, Aubert S, Lemaitre L, Haffner J, Biserte J, Gosselin B (2006) Multilocular cystic renal oncocytoma. J Clin Pathol 59(2):223–224PubMedCentralPubMed
21.
go back to reference Xiao GQ, Ko HB, Unger P (2013) Telangiectatic oncocytoma: a previously undescribed variant of renal oncocytoma. Am J Clin Pathol 140(1):103–108CrossRefPubMed Xiao GQ, Ko HB, Unger P (2013) Telangiectatic oncocytoma: a previously undescribed variant of renal oncocytoma. Am J Clin Pathol 140(1):103–108CrossRefPubMed
22.
go back to reference Taouli B, Thakur RK, Mannelli L, Babb JS, Kim S, Hecht EM et al (2009) Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging. Radiology 251(2):398–407CrossRefPubMed Taouli B, Thakur RK, Mannelli L, Babb JS, Kim S, Hecht EM et al (2009) Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging. Radiology 251(2):398–407CrossRefPubMed
23.
go back to reference Rowsell C, Fleshner N, Marrano P, Squire J, Evans A (2007) Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour. J Clin Pathol 60(4):426–428CrossRefPubMedCentralPubMed Rowsell C, Fleshner N, Marrano P, Squire J, Evans A (2007) Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour. J Clin Pathol 60(4):426–428CrossRefPubMedCentralPubMed
24.
go back to reference Tickoo SK, Reuter VE, Amin MB, Srigley JR, Epstein JI, Min KW et al (1999) Renal oncocytosis: a morphologic study of fourteen cases. Am J Surg Pathol 23(9):1094–1101CrossRefPubMed Tickoo SK, Reuter VE, Amin MB, Srigley JR, Epstein JI, Min KW et al (1999) Renal oncocytosis: a morphologic study of fourteen cases. Am J Surg Pathol 23(9):1094–1101CrossRefPubMed
25.
go back to reference Noguchi S, Nagashima Y, Shuin T, Kubota Y, Kitamura H, Yao M et al (1995) Renal oncocytoma containing “chromophobe” cells. Int J Urol 2(4):279–280CrossRefPubMed Noguchi S, Nagashima Y, Shuin T, Kubota Y, Kitamura H, Yao M et al (1995) Renal oncocytoma containing “chromophobe” cells. Int J Urol 2(4):279–280CrossRefPubMed
26.
go back to reference Dechet CB, Bostwick DG, Blute ML, Bryant SC, Zincke H (1999) Renal oncocytoma: multifocality, bilateralism, metachronous tumor development and coexistent renal cell carcinoma. J Urol 162(1):40–42CrossRefPubMed Dechet CB, Bostwick DG, Blute ML, Bryant SC, Zincke H (1999) Renal oncocytoma: multifocality, bilateralism, metachronous tumor development and coexistent renal cell carcinoma. J Urol 162(1):40–42CrossRefPubMed
27.
go back to reference Petrolla AA, MacLennan GT (2007) Renal cell carcinoma and other concurrent renal neoplasms. J Urol 178(5):2163CrossRefPubMed Petrolla AA, MacLennan GT (2007) Renal cell carcinoma and other concurrent renal neoplasms. J Urol 178(5):2163CrossRefPubMed
28.
go back to reference Salido M, Lloreta J, Melero C, García M, Placer J, Espinet B et al (2005) Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. Cancer Genet Cytogenet 163(2):160–163CrossRefPubMed Salido M, Lloreta J, Melero C, García M, Placer J, Espinet B et al (2005) Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. Cancer Genet Cytogenet 163(2):160–163CrossRefPubMed
29.
go back to reference Burger M, Denzinger S, Filbeck T, Hartmann A, Rössler W, Hammerschmied C. A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature Burger M, Denzinger S, Filbeck T, Hartmann A, Rössler W, Hammerschmied C. A metachronous, atypical, multifocal renal oncocytoma with a concomitant renal cell carcinoma of the contralateral side and bilateral multifocal oncocytomas: two case reports and review of literature
30.
go back to reference Amin MB, Crotty TB, Tickoo SK, Farrow GM (1997) Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol 21(1):1–12CrossRefPubMed Amin MB, Crotty TB, Tickoo SK, Farrow GM (1997) Renal oncocytoma: a reappraisal of morphologic features with clinicopathologic findings in 80 cases. Am J Surg Pathol 21(1):1–12CrossRefPubMed
31.
go back to reference Siu W, Hafez KS, Johnston WK 3rd, Wolf JS Jr (2007) Growth rates of renal cell carcinoma and oncocytoma under surveillance are similar. Urol Oncol 25(2):115–119CrossRefPubMed Siu W, Hafez KS, Johnston WK 3rd, Wolf JS Jr (2007) Growth rates of renal cell carcinoma and oncocytoma under surveillance are similar. Urol Oncol 25(2):115–119CrossRefPubMed
32.
go back to reference Hamamoto S, Okamura T, Mizuno K, Kamisawa H, Mogami T, Kohri K (2008) Renal oncocytoma with bilateral synchronous renal cell carcinoma in a patient undergoing long-term hemodialysis. Int J Urol 15(1):87–89CrossRefPubMed Hamamoto S, Okamura T, Mizuno K, Kamisawa H, Mogami T, Kohri K (2008) Renal oncocytoma with bilateral synchronous renal cell carcinoma in a patient undergoing long-term hemodialysis. Int J Urol 15(1):87–89CrossRefPubMed
33.
go back to reference Kuroda N, Tanaka A, Ohe C, Mikami S, Nagashima Y, Sasaki T et al (2012) Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects. Histol Histopathol 27(11):1407–1412PubMed Kuroda N, Tanaka A, Ohe C, Mikami S, Nagashima Y, Sasaki T et al (2012) Review of renal oncocytosis (multiple oncocytic lesions) with focus on clinical and pathobiological aspects. Histol Histopathol 27(11):1407–1412PubMed
Metadata
Title
Imaging spectrum of renal oncocytomas: a pictorial review with pathologic correlation
Authors
Kousei Ishigami
Aaron R. Jones
Laila Dahmoush
Leandro V. Leite
Marius G. Pakalniskis
Thomas J. Barloon
Publication date
01-02-2015
Publisher
Springer Berlin Heidelberg
Published in
Insights into Imaging / Issue 1/2015
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1007/s13244-014-0373-x

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