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Published in: Insights into Imaging 4/2010

Open Access 01-09-2010 | Review

Magnetic resonance imaging (MRI) in rectal cancer: a comprehensive review

Authors: Michael R. Torkzad, Lars Påhlman, Bengt Glimelius

Published in: Insights into Imaging | Issue 4/2010

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Abstract

Magnetic resonance imaging (MRI) has established itself as the primary method for local staging in patients with rectal cancer. This is due to several factors, most importantly because of the ability to assess the status of circumferential resection margin. There are several newer developments being introduced continuously, such as diffusion-weighted imaging and imaging with 3 T. Assessment of loco-regional lymph nodes has also been investigated extensively using different approaches, but more work needs to be done. Finally, evaluation of tumours during or after preoperative treatment is becoming an everyday reality. All these new aspects prompt a review of the most recent advances and opinions. In this review, a comprehensive overview of the current status of MRI in the loco-regional assessment and management of rectal cancer is presented. The findings on MRI and their accuracy are reviewed based on the most up-to-date evidence. Optimisation of MRI acquisition and relevant regional anatomy are also presented, based on published literature and our own experience.
Literature
1.
go back to reference Martling A, Holm T, Bremmer S, Lindholm J, Cedermark B, Blomqvist L (2003) Prognostic value of preoperative magnetic resonance imaging of the pelvis in rectal cancer. Br J Surg 90(11):1422–1428PubMed Martling A, Holm T, Bremmer S, Lindholm J, Cedermark B, Blomqvist L (2003) Prognostic value of preoperative magnetic resonance imaging of the pelvis in rectal cancer. Br J Surg 90(11):1422–1428PubMed
2.
go back to reference Brown G, Davies S, Williams GT, Bourne MW, Newcombe RG, Radcliffe AG, Blethyn J, Dallimore NS, Rees BI, Phillips CJ, Maughan TS (2004) Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging? Br J Cancer 91(1):23–29PubMedPubMedCentral Brown G, Davies S, Williams GT, Bourne MW, Newcombe RG, Radcliffe AG, Blethyn J, Dallimore NS, Rees BI, Phillips CJ, Maughan TS (2004) Effectiveness of preoperative staging in rectal cancer: digital rectal examination, endoluminal ultrasound or magnetic resonance imaging? Br J Cancer 91(1):23–29PubMedPubMedCentral
3.
go back to reference LeBlanc JK (2007) Imaging and management of rectal cancer. Nat Clin Pract Gastroenterol Hepatol 4(12):665–676PubMed LeBlanc JK (2007) Imaging and management of rectal cancer. Nat Clin Pract Gastroenterol Hepatol 4(12):665–676PubMed
4.
go back to reference Smith N, Brown G (2008) Preoperative staging in rectal cancer. Acta Oncol 47:20–31PubMed Smith N, Brown G (2008) Preoperative staging in rectal cancer. Acta Oncol 47:20–31PubMed
5.
go back to reference Taylor A, Sheridan M, McGee S, Halligan S (2005) Preoperative staging of rectal cancer by MRI; results of a UK survey. Clin Radiol 60(5):579–586PubMed Taylor A, Sheridan M, McGee S, Halligan S (2005) Preoperative staging of rectal cancer by MRI; results of a UK survey. Clin Radiol 60(5):579–586PubMed
6.
go back to reference Matsuoka H, Nakamura A, Masaki T, Sugiyama M, Takahara T, Hachiya J, Atomi Y (2003) A prospective comparison between multidetector-row computed tomography and magnetic resonance imaging in the preoperative evaluation of rectal carcinoma. Am J Surg 185(6):556–559PubMed Matsuoka H, Nakamura A, Masaki T, Sugiyama M, Takahara T, Hachiya J, Atomi Y (2003) A prospective comparison between multidetector-row computed tomography and magnetic resonance imaging in the preoperative evaluation of rectal carcinoma. Am J Surg 185(6):556–559PubMed
7.
go back to reference Burton S, Brown G, Daniels IR, Norman AR, Mason B, Cunningham D (2006) MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer 94(3):351–357PubMedPubMedCentral Burton S, Brown G, Daniels IR, Norman AR, Mason B, Cunningham D (2006) MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer 94(3):351–357PubMedPubMedCentral
8.
go back to reference Strassburg J, Lewin A, Ludwig K, Kilian L, Linke J, Loy V, Knuth P, Püttcher O, Ruehl U, Stöckmann F, Hackenthal M, Hopfenmüller W, Huppertz A (2007) Optimised surgery (so-called TME surgery) and high-resolution MRI in the planning of treatment of rectal carcinoma. Langenbecks Arch Surg 392(2):179–188PubMed Strassburg J, Lewin A, Ludwig K, Kilian L, Linke J, Loy V, Knuth P, Püttcher O, Ruehl U, Stöckmann F, Hackenthal M, Hopfenmüller W, Huppertz A (2007) Optimised surgery (so-called TME surgery) and high-resolution MRI in the planning of treatment of rectal carcinoma. Langenbecks Arch Surg 392(2):179–188PubMed
9.
go back to reference Burton S, Brown G, Daniels I, Norman A, Swift I, Abulafi M, Wotherspoon A, Tait D (2006) MRI identified prognostic features of tumors in distal sigmoid, rectosigmoid, and upper rectum: treatment with radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys 65(2):445–451PubMed Burton S, Brown G, Daniels I, Norman A, Swift I, Abulafi M, Wotherspoon A, Tait D (2006) MRI identified prognostic features of tumors in distal sigmoid, rectosigmoid, and upper rectum: treatment with radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys 65(2):445–451PubMed
10.
go back to reference Nicholls RJ, Tekkis PP (2008) Multidisciplinary treatment of cancer of the rectum: a European approach. Surg Oncol Clin N Am 17(3):533–551, viiiPubMed Nicholls RJ, Tekkis PP (2008) Multidisciplinary treatment of cancer of the rectum: a European approach. Surg Oncol Clin N Am 17(3):533–551, viiiPubMed
11.
go back to reference Branagan G, Chave H, Fuller C, McGee S, Finnis D (2004) Can magnetic resonance imaging predict circumferential margins and TNM stage in rectal cancer? Dis Colon Rectum 47(8):1317–1322PubMed Branagan G, Chave H, Fuller C, McGee S, Finnis D (2004) Can magnetic resonance imaging predict circumferential margins and TNM stage in rectal cancer? Dis Colon Rectum 47(8):1317–1322PubMed
12.
go back to reference Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J (2004) Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging–a meta-analysis. Radiology 232(3):773–783PubMed Bipat S, Glas AS, Slors FJ, Zwinderman AH, Bossuyt PM, Stoker J (2004) Rectal cancer: local staging and assessment of lymph node involvement with endoluminal US, CT, and MR imaging–a meta-analysis. Radiology 232(3):773–783PubMed
13.
go back to reference Rovera F, Dionigi G, Boni L, Cutaia S, Diurni M, Dionigi R (2007) The role of EUS and MRI in rectal cancer staging. Surg Oncol 16(Suppl 1):S51–S52PubMed Rovera F, Dionigi G, Boni L, Cutaia S, Diurni M, Dionigi R (2007) The role of EUS and MRI in rectal cancer staging. Surg Oncol 16(Suppl 1):S51–S52PubMed
14.
go back to reference MERCURY Study Group (2006) Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ 333(7572):779–785PubMedCentral MERCURY Study Group (2006) Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study. BMJ 333(7572):779–785PubMedCentral
15.
go back to reference Suzuki C, Torkzad MR, Tanaka S, Palmer G, Lindholm J, Holm T, Blomqvist L (2008) The importance of rectal cancer MRI protocols on interpretation accuracy. World J Surg Oncol 6:89PubMedPubMedCentral Suzuki C, Torkzad MR, Tanaka S, Palmer G, Lindholm J, Holm T, Blomqvist L (2008) The importance of rectal cancer MRI protocols on interpretation accuracy. World J Surg Oncol 6:89PubMedPubMedCentral
16.
go back to reference Brown G (2005) Thin section MRI in multidisciplinary pre-operative decision making for patients with rectal cancer. Br J Radiol 78(Spec No 2):S117–S127PubMed Brown G (2005) Thin section MRI in multidisciplinary pre-operative decision making for patients with rectal cancer. Br J Radiol 78(Spec No 2):S117–S127PubMed
17.
go back to reference Kim YW, Kim NK, Min BS, Kim H, Pyo J, Kim MJ, Cha SH (2008) A prospective comparison study for predicting circumferential resection margin between preoperative MRI and whole mount sections in mid-rectal cancer: significance of different scan planes. Eur J Surg Oncol 34(6):648–654PubMed Kim YW, Kim NK, Min BS, Kim H, Pyo J, Kim MJ, Cha SH (2008) A prospective comparison study for predicting circumferential resection margin between preoperative MRI and whole mount sections in mid-rectal cancer: significance of different scan planes. Eur J Surg Oncol 34(6):648–654PubMed
18.
go back to reference Bond S, Joshi N, Petroudi S, Brady M (2007) Estimating the mesorectal fascia in MRI. Inf Process Med Imag 20:650–661 Bond S, Joshi N, Petroudi S, Brady M (2007) Estimating the mesorectal fascia in MRI. Inf Process Med Imag 20:650–661
19.
go back to reference Purkayastha S, Tekkis PP, Athanasiou T, Tilney HS, Darzi AW, Heriot AG (2007) Diagnostic precision of magnetic resonance imaging for preoperative prediction of the circumferential margin involvement in patients with rectal cancer. Colorectal Dis 9(5):402–411PubMed Purkayastha S, Tekkis PP, Athanasiou T, Tilney HS, Darzi AW, Heriot AG (2007) Diagnostic precision of magnetic resonance imaging for preoperative prediction of the circumferential margin involvement in patients with rectal cancer. Colorectal Dis 9(5):402–411PubMed
20.
go back to reference Rafaelsen SR, Sørensen T, Jakobsen A, Bisgaard C, Lindebjerg J (2008) Transrectal ultrasonography and magnetic resonance imaging in the staging of rectal cancer. Effect of experience. Scand J Gastroenterol 43(4):440–446PubMed Rafaelsen SR, Sørensen T, Jakobsen A, Bisgaard C, Lindebjerg J (2008) Transrectal ultrasonography and magnetic resonance imaging in the staging of rectal cancer. Effect of experience. Scand J Gastroenterol 43(4):440–446PubMed
21.
go back to reference Goh V, Halligan S, Bartram CI (2004) Local radiological staging of rectal cancer. Clin Radiol 59(3):215–226PubMed Goh V, Halligan S, Bartram CI (2004) Local radiological staging of rectal cancer. Clin Radiol 59(3):215–226PubMed
22.
go back to reference Salerno G, Daniels IR, Brown G (2006) Magnetic resonance imaging of the low rectum: defining the radiological anatomy. Colorectal Dis 8(Suppl 3):10–13PubMed Salerno G, Daniels IR, Brown G (2006) Magnetic resonance imaging of the low rectum: defining the radiological anatomy. Colorectal Dis 8(Suppl 3):10–13PubMed
23.
go back to reference Salerno G, Sinnatamby C, Branagan G, Daniels IR, Heald RJ, Moran BJ (2006) Defining the rectum: surgically, radiologically and anatomically. Colorectal Dis 8(Suppl 3):5–9PubMed Salerno G, Sinnatamby C, Branagan G, Daniels IR, Heald RJ, Moran BJ (2006) Defining the rectum: surgically, radiologically and anatomically. Colorectal Dis 8(Suppl 3):5–9PubMed
24.
go back to reference Torkzad MR, Blomqvist L (2005) The mesorectum: morphometric assessment with magnetic resonance imaging. Eur Radiol 15(6):1184–1191PubMed Torkzad MR, Blomqvist L (2005) The mesorectum: morphometric assessment with magnetic resonance imaging. Eur Radiol 15(6):1184–1191PubMed
25.
go back to reference Allen SD, Gada V, Blunt DM (2007) Variation of mesorectal volume with abdominal fat volume in patients with rectal carcinoma: assessment with MRI. Br J Radiol 80(952):242–247PubMed Allen SD, Gada V, Blunt DM (2007) Variation of mesorectal volume with abdominal fat volume in patients with rectal carcinoma: assessment with MRI. Br J Radiol 80(952):242–247PubMed
26.
go back to reference Torkzad MR, Hansson KA, Lindholm J, Martling A, Blomqvist L (2007) Significance of mesorectal volume in staging of rectal cancer with magnetic resonance imaging and the assessment of involvement of the mesorectal fascia. Eur Radiol 17(7):1694–1699PubMed Torkzad MR, Hansson KA, Lindholm J, Martling A, Blomqvist L (2007) Significance of mesorectal volume in staging of rectal cancer with magnetic resonance imaging and the assessment of involvement of the mesorectal fascia. Eur Radiol 17(7):1694–1699PubMed
27.
go back to reference Peschaud F, Cuenod CA, Benoist S, Julié C, Beauchet A, Siauve N, Taieb-Kasbi F, Penna C, Nordlinger B (2005) Accuracy of magnetic resonance imaging in rectal cancer depends on location of the tumor. Dis Colon Rectum 48(8):1603–1609PubMed Peschaud F, Cuenod CA, Benoist S, Julié C, Beauchet A, Siauve N, Taieb-Kasbi F, Penna C, Nordlinger B (2005) Accuracy of magnetic resonance imaging in rectal cancer depends on location of the tumor. Dis Colon Rectum 48(8):1603–1609PubMed
28.
go back to reference Diop M, Parratte B, Tatu L, Vuillier F, Brunelle S, Monnier G (2003) “Mesorectum”: the surgical value of an anatomical approach. Surg Radiol Anat 25(3–4):290–304PubMed Diop M, Parratte B, Tatu L, Vuillier F, Brunelle S, Monnier G (2003) “Mesorectum”: the surgical value of an anatomical approach. Surg Radiol Anat 25(3–4):290–304PubMed
29.
go back to reference Lindsey I, Warren B, Mortensen N (2004) Optimal total mesorectal excision for rectal cancer is by dissection in front of Denonvilliers’ fascia (comment on Br J Surg 2004; 91: 121-123). Br J Surg 91 (7): 897 Lindsey I, Warren B, Mortensen N (2004) Optimal total mesorectal excision for rectal cancer is by dissection in front of Denonvilliers’ fascia (comment on Br J Surg 2004; 91: 121-123). Br J Surg 91 (7): 897
30.
go back to reference Lahaye MJ, Engelen SM, Nelemans PJ, Beets GL, van de Velde CJ, van Engelshoven JM, Beets-Tan RG (2005) Imaging for predicting the risk factors——the circumferential resection margin and nodal disease—of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 26(4):259–268PubMed Lahaye MJ, Engelen SM, Nelemans PJ, Beets GL, van de Velde CJ, van Engelshoven JM, Beets-Tan RG (2005) Imaging for predicting the risk factors——the circumferential resection margin and nodal disease—of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 26(4):259–268PubMed
31.
go back to reference Baik SH, Kim NK, Lee KY, Sohn SK, Cho CH, Kim MJ, Kim H, Shinn RK (2008) Factors influencing pathologic results after total mesorectal excision for rectal cancer: analysis of consecutive 100 cases. Ann Surg Oncol 15(3):721–728PubMed Baik SH, Kim NK, Lee KY, Sohn SK, Cho CH, Kim MJ, Kim H, Shinn RK (2008) Factors influencing pathologic results after total mesorectal excision for rectal cancer: analysis of consecutive 100 cases. Ann Surg Oncol 15(3):721–728PubMed
32.
go back to reference Wolberink SV, Beets-Tan RG, Nagtegaal ID, Wiggers T (2006) Preoperative assessment of the circumferential margin in rectal cancer is more informative in treatment planning than the T stage. Tech Coloproctol 10(3):171–176PubMed Wolberink SV, Beets-Tan RG, Nagtegaal ID, Wiggers T (2006) Preoperative assessment of the circumferential margin in rectal cancer is more informative in treatment planning than the T stage. Tech Coloproctol 10(3):171–176PubMed
33.
go back to reference Mathur P, Smith JJ, Ramsey C, Owen M, Thorpe A, Karim S, Burke C, Ramesh S, Dawson PM (2003) Comparison of CT and MRI in the pre-operative staging of rectal adenocarcinoma and prediction of circumferential resection margin involvement by MRI. Colorectal Dis 5(5):396–401PubMed Mathur P, Smith JJ, Ramsey C, Owen M, Thorpe A, Karim S, Burke C, Ramesh S, Dawson PM (2003) Comparison of CT and MRI in the pre-operative staging of rectal adenocarcinoma and prediction of circumferential resection margin involvement by MRI. Colorectal Dis 5(5):396–401PubMed
34.
go back to reference Poon FW, McDonald A, Anderson JH, Duthie F, Rodger C, McCurrach G, McKee RF, Horgan PG, Foulis AK, Chong D, Finlay IG (2005) Accuracy of thin section magnetic resonance using phased-array pelvic coil in predicting the T-staging of rectal cancer. Eur J Radiol 53(2):256–262PubMed Poon FW, McDonald A, Anderson JH, Duthie F, Rodger C, McCurrach G, McKee RF, Horgan PG, Foulis AK, Chong D, Finlay IG (2005) Accuracy of thin section magnetic resonance using phased-array pelvic coil in predicting the T-staging of rectal cancer. Eur J Radiol 53(2):256–262PubMed
35.
go back to reference Kraaz W (2007) Magnetic resonance imaging for preoperative staging of rectal cancer in clinical practice: high accuracy in predicting circumferential margin with clinical benefit. Colorectal Dis 9(5):412–419PubMed Kraaz W (2007) Magnetic resonance imaging for preoperative staging of rectal cancer in clinical practice: high accuracy in predicting circumferential margin with clinical benefit. Colorectal Dis 9(5):412–419PubMed
36.
go back to reference Ferri M, Laghi A, Mingazzini P, Iafrate F, Meli L, Ricci F, Passariello R, Ziparo V (2005) Pre-operative assessment of extramural invasion and sphincteral involvement in rectal cancer by magnetic resonance imaging with phased-array coil. Colorectal Dis 7(4):387–393PubMed Ferri M, Laghi A, Mingazzini P, Iafrate F, Meli L, Ricci F, Passariello R, Ziparo V (2005) Pre-operative assessment of extramural invasion and sphincteral involvement in rectal cancer by magnetic resonance imaging with phased-array coil. Colorectal Dis 7(4):387–393PubMed
37.
go back to reference Strassburg J, Junginger T, Trinh T, Püttcher O, Oberholzer K, Heald RJ, Hermanek P (2008) Magnetic resonance imaging (MRI)-based indication for neoadjuvant treatment of rectal carcinoma and the surrogate endpoint CRM status. Int J Colorectal Dis 23(11):1099–1107PubMed Strassburg J, Junginger T, Trinh T, Püttcher O, Oberholzer K, Heald RJ, Hermanek P (2008) Magnetic resonance imaging (MRI)-based indication for neoadjuvant treatment of rectal carcinoma and the surrogate endpoint CRM status. Int J Colorectal Dis 23(11):1099–1107PubMed
38.
go back to reference Glimelius B (2001) Pre- or postoperative radiotherapy in rectal cancer–more to learn? Radiother Oncol 61(1):1–5PubMed Glimelius B (2001) Pre- or postoperative radiotherapy in rectal cancer–more to learn? Radiother Oncol 61(1):1–5PubMed
39.
go back to reference Valentini V, Aristei C, Glimelius B, Minsky BD, Beets-Tan R, Borras JM, Haustermans K, Maingon P, Overgaard J, Pahlman L, Quirke P, Schmoll HJ, Sebag-Montefiore D, Taylor I, Van Cutsem E, Van de Velde C, Cellini N, Latini P, Committee S (2009) Multidisciplinary rectal cancer management: 2nd European Rectal Cancer Consensus Conference (EURECA-CC2). Radiother Oncol 92(2):148–163PubMed Valentini V, Aristei C, Glimelius B, Minsky BD, Beets-Tan R, Borras JM, Haustermans K, Maingon P, Overgaard J, Pahlman L, Quirke P, Schmoll HJ, Sebag-Montefiore D, Taylor I, Van Cutsem E, Van de Velde C, Cellini N, Latini P, Committee S (2009) Multidisciplinary rectal cancer management: 2nd European Rectal Cancer Consensus Conference (EURECA-CC2). Radiother Oncol 92(2):148–163PubMed
40.
go back to reference Taylor A, Slater A, Mapstone N, Taylor S, Halligan S (2007) Staging rectal cancer: MRI compared to MDCT. Abdom Imaging 32(3):323–327PubMed Taylor A, Slater A, Mapstone N, Taylor S, Halligan S (2007) Staging rectal cancer: MRI compared to MDCT. Abdom Imaging 32(3):323–327PubMed
41.
go back to reference Kim NK, Min BS, Kim H, Pyo J, Kim MJ, Cha SH (2008) A prospective comparison study for predicting circumferential resection margin between preoperative MRI and whole mount sections in mid-rectal cancer: significance of different scan planes. Eur J Surg Oncol 34(6):648–654PubMed Kim NK, Min BS, Kim H, Pyo J, Kim MJ, Cha SH (2008) A prospective comparison study for predicting circumferential resection margin between preoperative MRI and whole mount sections in mid-rectal cancer: significance of different scan planes. Eur J Surg Oncol 34(6):648–654PubMed
42.
go back to reference Taylor FG, Swift RI, Blomqvist L, Brown G (2008) A systematic approach to the interpretation of preoperative staging MRI for rectal cancer. AJR Am J Roentgenol 191(6):1827–1835PubMed Taylor FG, Swift RI, Blomqvist L, Brown G (2008) A systematic approach to the interpretation of preoperative staging MRI for rectal cancer. AJR Am J Roentgenol 191(6):1827–1835PubMed
43.
go back to reference Rao SX, Zeng MS, Xu JM, Qin XY, Chen CZ, Li RC, Hou YY (2007) Assessment of T staging and mesorectal fascia status using high-resolution MRI in rectal cancer with rectal distention. World J Gastroenterol 13(30):4141–4146PubMedPubMedCentral Rao SX, Zeng MS, Xu JM, Qin XY, Chen CZ, Li RC, Hou YY (2007) Assessment of T staging and mesorectal fascia status using high-resolution MRI in rectal cancer with rectal distention. World J Gastroenterol 13(30):4141–4146PubMedPubMedCentral
44.
go back to reference Slater A, Halligan S, Taylor SA, Marshall M (2006) Distance between the rectal wall and mesorectal fascia measured by MRI: effect of rectal distension and implications for preoperative prediction of a tumour-free circumferential resection margin. Clin Radiol 61(1):65–70PubMed Slater A, Halligan S, Taylor SA, Marshall M (2006) Distance between the rectal wall and mesorectal fascia measured by MRI: effect of rectal distension and implications for preoperative prediction of a tumour-free circumferential resection margin. Clin Radiol 61(1):65–70PubMed
45.
go back to reference Engelen SM, Beets GL, Beets-Tan RG (2007) Role of preoperative local and distant staging in rectal cancer. Onkologie 30(3):141–145PubMed Engelen SM, Beets GL, Beets-Tan RG (2007) Role of preoperative local and distant staging in rectal cancer. Onkologie 30(3):141–145PubMed
46.
go back to reference Matsuoka H, Nakamura A, Sugiyama M, Hachiya J, Atomi Y, Masaki T (2004) MRI diagnosis of mesorectal lymph node metastasis in patients with rectal carcinoma. What is the optimal criterion? Anticancer Res 24(6):4097–4101PubMed Matsuoka H, Nakamura A, Sugiyama M, Hachiya J, Atomi Y, Masaki T (2004) MRI diagnosis of mesorectal lymph node metastasis in patients with rectal carcinoma. What is the optimal criterion? Anticancer Res 24(6):4097–4101PubMed
47.
go back to reference Bianchi P, Ceriani C, Palmisano A, Pompili G, Passoni GR, Rottoli M, Cappellani A, Montorsi M (2006) A prospective comparison of endorectal ultrasound and pelvic magnetic resonance in the preoperative staging of rectal cancer. Ann Ital Chir 77(1):41–46PubMed Bianchi P, Ceriani C, Palmisano A, Pompili G, Passoni GR, Rottoli M, Cappellani A, Montorsi M (2006) A prospective comparison of endorectal ultrasound and pelvic magnetic resonance in the preoperative staging of rectal cancer. Ann Ital Chir 77(1):41–46PubMed
48.
go back to reference Panzironi G, De Vargas MM, Manganaro L, Ballesio L, Ricci F, Casale A, Campagnano D (2004) Preoperative locoregional staging of rectal carcinoma: comparison of MR. TRUS and Multislice CT. Personal experience. Radiol Med 107(4):344–355PubMed Panzironi G, De Vargas MM, Manganaro L, Ballesio L, Ricci F, Casale A, Campagnano D (2004) Preoperative locoregional staging of rectal carcinoma: comparison of MR. TRUS and Multislice CT. Personal experience. Radiol Med 107(4):344–355PubMed
49.
go back to reference Kim JH, Beets GL, Kim MJ, Kessels AG, Beets-Tan RG (2004) High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur J Radiol 52(1):78–83PubMed Kim JH, Beets GL, Kim MJ, Kessels AG, Beets-Tan RG (2004) High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur J Radiol 52(1):78–83PubMed
50.
go back to reference Koh DM, Brown G, Husband JE (2006) Nodal staging in rectal cancer. Abdom Imaging 31(6):652–659PubMed Koh DM, Brown G, Husband JE (2006) Nodal staging in rectal cancer. Abdom Imaging 31(6):652–659PubMed
51.
go back to reference Matsuoka H, Nakamura A, Masaki T, Sugiyama M, Nitatori T, Ohkura Y, Sakamoto A, Atomi Y (2007) Optimal diagnostic criteria for lateral pelvic lymph node metastasis in rectal carcinoma. Anticancer Res 27(5B):3529–3533PubMed Matsuoka H, Nakamura A, Masaki T, Sugiyama M, Nitatori T, Ohkura Y, Sakamoto A, Atomi Y (2007) Optimal diagnostic criteria for lateral pelvic lymph node metastasis in rectal carcinoma. Anticancer Res 27(5B):3529–3533PubMed
52.
go back to reference Matsuoka H, Masaki T, Sugiyama M, Nakamura A, Takahara T, Hachiya J, Atomi Y (2004) Gadolinium enhanced endorectal coil and air enema magnetic resonance imaging as a useful tool in the preoperative examination of patients with rectal carcinoma. Hepatogastroenterology 51(55):131–135PubMed Matsuoka H, Masaki T, Sugiyama M, Nakamura A, Takahara T, Hachiya J, Atomi Y (2004) Gadolinium enhanced endorectal coil and air enema magnetic resonance imaging as a useful tool in the preoperative examination of patients with rectal carcinoma. Hepatogastroenterology 51(55):131–135PubMed
53.
go back to reference Koh DM, Brown G, Temple L, Raja A, Toomey P, Bett N, Norman AR, Husband JE (2004) Rectal cancer: mesorectal lymph nodes at MR imaging with USPIO versus histopathologic findings—initial observations. Radiology 231(1):91–99PubMed Koh DM, Brown G, Temple L, Raja A, Toomey P, Bett N, Norman AR, Husband JE (2004) Rectal cancer: mesorectal lymph nodes at MR imaging with USPIO versus histopathologic findings—initial observations. Radiology 231(1):91–99PubMed
54.
go back to reference Lahaye MJ, Engelen SM, Kessels AG, de Bruïne AP, von Meyenfeldt MF, van Engelshoven JM, van de Velde CJ, Beets GL, Beets-Tan RG (2008) USPIO-enhanced MR imaging for nodal staging in patients with primary rectal cancer: predictive criteria. Radiology 246(3):804–811PubMed Lahaye MJ, Engelen SM, Kessels AG, de Bruïne AP, von Meyenfeldt MF, van Engelshoven JM, van de Velde CJ, Beets GL, Beets-Tan RG (2008) USPIO-enhanced MR imaging for nodal staging in patients with primary rectal cancer: predictive criteria. Radiology 246(3):804–811PubMed
55.
go back to reference Lin G, Ho KC, Wang JJ, Ng KK, Wai YY, Chen YT, Chang CJ, Ng SH, Lai CH, Yen TC (2008) Detection of lymph node metastasis in cervical and uterine cancers by diffusion-weighted magnetic resonance imaging at 3 T. J Magn Reson Imaging 28:128–135PubMed Lin G, Ho KC, Wang JJ, Ng KK, Wai YY, Chen YT, Chang CJ, Ng SH, Lai CH, Yen TC (2008) Detection of lymph node metastasis in cervical and uterine cancers by diffusion-weighted magnetic resonance imaging at 3 T. J Magn Reson Imaging 28:128–135PubMed
56.
go back to reference Beets-Tan RGH, Lambregts DMJ, Beets GL, Engelen SME, Voth V, Leiner T, Lahaye MJ (2009) Gadovosfeset trisodium (Vasovist®) enhanced MR lymph node detection: initial observations. Open Magn Reson J 2:28-32 Beets-Tan RGH, Lambregts DMJ, Beets GL, Engelen SME, Voth V, Leiner T, Lahaye MJ (2009) Gadovosfeset trisodium (Vasovist®) enhanced MR lymph node detection: initial observations. Open Magn Reson J 2:28-32
57.
go back to reference Lahaye MJ, Kessels AG, Beets GL (2008) Location of involved mesorectal and extramesorectal lymph nodes in patients with primary rectal cancer: preoperative assessment with MR imaging. Eur J Surg Oncol 34(7):776–781PubMed Lahaye MJ, Kessels AG, Beets GL (2008) Location of involved mesorectal and extramesorectal lymph nodes in patients with primary rectal cancer: preoperative assessment with MR imaging. Eur J Surg Oncol 34(7):776–781PubMed
58.
go back to reference Aigner F, Trieb T, Ofner D, Margreiter R, Devries A, Zbar AP, Fritsch H (2007) Anatomical considerations in TNM staging and therapeutical procedures for low rectal cancer. Int J Colorectal Dis 22(11):1339–1346PubMed Aigner F, Trieb T, Ofner D, Margreiter R, Devries A, Zbar AP, Fritsch H (2007) Anatomical considerations in TNM staging and therapeutical procedures for low rectal cancer. Int J Colorectal Dis 22(11):1339–1346PubMed
59.
go back to reference Koh DM, Brown G, Temple L, Blake H, Raja A, Toomey P, Bett N, Farhat S, Norman AR, Daniels I, Husband JE (2005) Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations. Eur Radiol 15(8):1650–1657PubMed Koh DM, Brown G, Temple L, Blake H, Raja A, Toomey P, Bett N, Farhat S, Norman AR, Daniels I, Husband JE (2005) Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations. Eur Radiol 15(8):1650–1657PubMed
60.
go back to reference Arii K, Takifuji K, Yokoyama S, Matsuda K, Higashiguchi T, Tominaga T, Oku Y, Tani M, Yamaue H (2006) Preoperative evaluation of pelvic lateral lymph node of patients with lower rectal cancer: comparison study of MR imaging and CT in 53 patients. Langenbecks Arch Surg 391(5):449–454PubMed Arii K, Takifuji K, Yokoyama S, Matsuda K, Higashiguchi T, Tominaga T, Oku Y, Tani M, Yamaue H (2006) Preoperative evaluation of pelvic lateral lymph node of patients with lower rectal cancer: comparison study of MR imaging and CT in 53 patients. Langenbecks Arch Surg 391(5):449–454PubMed
61.
go back to reference Yano H, Moran BJ (2008) The incidence of lateral pelvic side-wall nodal involvement in low rectal cancer may be similar in Japan and the West. Br J Surg 95(1):33–49PubMed Yano H, Moran BJ (2008) The incidence of lateral pelvic side-wall nodal involvement in low rectal cancer may be similar in Japan and the West. Br J Surg 95(1):33–49PubMed
62.
go back to reference Quirke P, Cuvelier C, Ensari A, Glimelius B, Laurberg S, Ortiz H, Piard F, Punt CJ, Glenthoj A, Pennickx F, Seymour M, Valentini V, Williams G, Nagtegaal ID (2010) Evidence-based medicine: the time has come to set standards for staging. J Pathol 221(4):357–360PubMed Quirke P, Cuvelier C, Ensari A, Glimelius B, Laurberg S, Ortiz H, Piard F, Punt CJ, Glenthoj A, Pennickx F, Seymour M, Valentini V, Williams G, Nagtegaal ID (2010) Evidence-based medicine: the time has come to set standards for staging. J Pathol 221(4):357–360PubMed
63.
go back to reference Salerno G, Daniels I, Heald RJ, Brown G, Moran BJ (2004) Management and imaging of low rectal carcinoma. Surg Oncol 13(2–3):55–61PubMed Salerno G, Daniels I, Heald RJ, Brown G, Moran BJ (2004) Management and imaging of low rectal carcinoma. Surg Oncol 13(2–3):55–61PubMed
64.
go back to reference Shihab OC, Moran BJ, Heald RJ, Quirke P, Brown G (2009) MRI staging of low rectal cancer. Eur Radiol 19(3):643–650PubMed Shihab OC, Moran BJ, Heald RJ, Quirke P, Brown G (2009) MRI staging of low rectal cancer. Eur Radiol 19(3):643–650PubMed
65.
go back to reference Salerno GV, Daniels IR, Moran BJ, Heald RJ, Thomas K, Brown G (2009) Magnetic resonance imaging prediction of an involved surgical resection margin in low rectal cancer. Dis Colon Rectum 52(4):632–639PubMed Salerno GV, Daniels IR, Moran BJ, Heald RJ, Thomas K, Brown G (2009) Magnetic resonance imaging prediction of an involved surgical resection margin in low rectal cancer. Dis Colon Rectum 52(4):632–639PubMed
66.
go back to reference Torkzad M, Lindholm J, Martling A, Blomqvist L (2003) Retrospective measurement of different size parameters of non-radiated rectal cancer on MR images and pathology slides and their comparison. Eur Radiol 13(10):2271–2277PubMed Torkzad M, Lindholm J, Martling A, Blomqvist L (2003) Retrospective measurement of different size parameters of non-radiated rectal cancer on MR images and pathology slides and their comparison. Eur Radiol 13(10):2271–2277PubMed
67.
go back to reference Smith NJ, Barbachano Y, Norman AR, Swift RI, Abulafi AM, Brown G (2008) Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer. Br J Surg 95(2):229–236PubMed Smith NJ, Barbachano Y, Norman AR, Swift RI, Abulafi AM, Brown G (2008) Prognostic significance of magnetic resonance imaging-detected extramural vascular invasion in rectal cancer. Br J Surg 95(2):229–236PubMed
68.
go back to reference Smith NJ, Shihab O, Arnaout A, Swift RI, Brown G (2008) MRI for detection of extramural vascular invasion in rectal cancer. AJR Am J Roentgenol 191(5):1517–1522PubMed Smith NJ, Shihab O, Arnaout A, Swift RI, Brown G (2008) MRI for detection of extramural vascular invasion in rectal cancer. AJR Am J Roentgenol 191(5):1517–1522PubMed
69.
go back to reference Strassburg J (2004) Magnetic resonance imaging in rectal cancer: the MERCURY experience. Tech Coloproctol 8(Suppl 1):s16–s18PubMed Strassburg J (2004) Magnetic resonance imaging in rectal cancer: the MERCURY experience. Tech Coloproctol 8(Suppl 1):s16–s18PubMed
70.
go back to reference Brown G, Daniels IR (2005) Preoperative staging of rectal cancer: the MERCURY research project. Recent Results Cancer Res 165:58–74PubMed Brown G, Daniels IR (2005) Preoperative staging of rectal cancer: the MERCURY research project. Recent Results Cancer Res 165:58–74PubMed
71.
go back to reference MERCURY Study Group (2007) Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study. Radiology 243(1):132–139 MERCURY Study Group (2007) Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study. Radiology 243(1):132–139
72.
go back to reference Park SH (2008) Degree of error of thin-section MR in measuring extramural depth of tumor invasion in patients with rectal cancer. Radiology 246(2):647PubMed Park SH (2008) Degree of error of thin-section MR in measuring extramural depth of tumor invasion in patients with rectal cancer. Radiology 246(2):647PubMed
73.
go back to reference Low RN, McCue M, Barone R, Saleh F, Song T (2003) MR staging of primary colorectal carcinoma: comparison with surgical and histopathologic findings. Abdom Imaging 28(6):784–793PubMed Low RN, McCue M, Barone R, Saleh F, Song T (2003) MR staging of primary colorectal carcinoma: comparison with surgical and histopathologic findings. Abdom Imaging 28(6):784–793PubMed
74.
go back to reference Guillem JG, Díaz-González JA, Minsky BD, Valentini V, Jeong SY, Rodriguez-Bigas MA, Coco C, Leon R, Hernandez-Lizoain JL, Aristu JJ, Riedel ER, Nitti D, Wong WD, Pucciarelli S (2008) cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted. J Clin Oncol 26(3):368–373PubMed Guillem JG, Díaz-González JA, Minsky BD, Valentini V, Jeong SY, Rodriguez-Bigas MA, Coco C, Leon R, Hernandez-Lizoain JL, Aristu JJ, Riedel ER, Nitti D, Wong WD, Pucciarelli S (2008) cT3N0 rectal cancer: potential overtreatment with preoperative chemoradiotherapy is warranted. J Clin Oncol 26(3):368–373PubMed
75.
go back to reference O'Neil BH, Tepper JE (2007) Current options for the management of rectal cancer. Curr Treat Options Oncol 8(5):331–338PubMed O'Neil BH, Tepper JE (2007) Current options for the management of rectal cancer. Curr Treat Options Oncol 8(5):331–338PubMed
76.
go back to reference Zhang XM, Zhang HL, Yu D, Dai Y, Bi D, Prince MR, Li C (2008) 3-T MRI of rectal carcinoma: preoperative diagnosis, staging, and planning of sphincter-sparing surgery. AJR Am J Roentgenol 190(5):1271–1278PubMed Zhang XM, Zhang HL, Yu D, Dai Y, Bi D, Prince MR, Li C (2008) 3-T MRI of rectal carcinoma: preoperative diagnosis, staging, and planning of sphincter-sparing surgery. AJR Am J Roentgenol 190(5):1271–1278PubMed
77.
go back to reference Kim H, Lim JS, Choi JY, Park J, Chung YE, Kim MJ, Choi E, Kim NK, Kim KW (2010) Rectal cancer: comparison of accuracy of local-regional staging with two- and three-dimensional preoperative 3-T MR imaging. Radiology 254(2):485–492PubMed Kim H, Lim JS, Choi JY, Park J, Chung YE, Kim MJ, Choi E, Kim NK, Kim KW (2010) Rectal cancer: comparison of accuracy of local-regional staging with two- and three-dimensional preoperative 3-T MR imaging. Radiology 254(2):485–492PubMed
78.
go back to reference Fütterer JJ, Yakar D, Strijk SP, Barentsz JO (2008) Preoperative 3 T MR imaging of rectal cancer: local staging accuracy using a two-dimensional and three-dimensional T2-weighted turbo spin echo sequence. Eur J Radiol 65(1):66–71PubMed Fütterer JJ, Yakar D, Strijk SP, Barentsz JO (2008) Preoperative 3 T MR imaging of rectal cancer: local staging accuracy using a two-dimensional and three-dimensional T2-weighted turbo spin echo sequence. Eur J Radiol 65(1):66–71PubMed
79.
go back to reference Kim MJ, Lim JS, Oh YT, Kim JH, Chung JJ, Joo SH, Kim NK, Lee KY, Kim WH, Kim KW (2004) Preoperative MRI of rectal cancer with and without rectal water filling: an intraindividual comparison. AJR Am J Roentgenol 182(6):1469–1476PubMed Kim MJ, Lim JS, Oh YT, Kim JH, Chung JJ, Joo SH, Kim NK, Lee KY, Kim WH, Kim KW (2004) Preoperative MRI of rectal cancer with and without rectal water filling: an intraindividual comparison. AJR Am J Roentgenol 182(6):1469–1476PubMed
80.
go back to reference Piippo U, Pääkkö E, Mäkinen M, Mäkelä J (2008) Local staging of rectal cancer using the black lumen magnetic resonance imaging technique. Scand J Surg 97(3):237–242PubMed Piippo U, Pääkkö E, Mäkinen M, Mäkelä J (2008) Local staging of rectal cancer using the black lumen magnetic resonance imaging technique. Scand J Surg 97(3):237–242PubMed
81.
go back to reference Vliegen RF, Beets GL, von Meyenfeldt MF, Kessels AG, Lemaire EE, van Engelshoven JM, Beets-Tan RG (2005) Rectal cancer: MR imaging in local staging—is gadolinium-based contrast material helpful? Radiology 234(1):179–188PubMed Vliegen RF, Beets GL, von Meyenfeldt MF, Kessels AG, Lemaire EE, van Engelshoven JM, Beets-Tan RG (2005) Rectal cancer: MR imaging in local staging—is gadolinium-based contrast material helpful? Radiology 234(1):179–188PubMed
82.
go back to reference Rosenberg R, Herrmann K, Gertler R, Künzli B, Essler M, Lordick F, Becker K, Schuster T, Geinitz H, Maak M, Schwaiger M, Siewert JR, Krause B (2009) The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT. Int J Colorectal Dis 24(2):191–200PubMed Rosenberg R, Herrmann K, Gertler R, Künzli B, Essler M, Lordick F, Becker K, Schuster T, Geinitz H, Maak M, Schwaiger M, Siewert JR, Krause B (2009) The predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CT. Int J Colorectal Dis 24(2):191–200PubMed
83.
go back to reference Hosonuma T, Tozaki M, Ichiba N, Sakuma T, Hayashi D, Yanaga K, Fukuda K (2006) Clinical usefulness of diffusion-weighted imaging using low and high b-values to detect rectal cancer. Magn Reson Med Sci 5(4):173–177PubMed Hosonuma T, Tozaki M, Ichiba N, Sakuma T, Hayashi D, Yanaga K, Fukuda K (2006) Clinical usefulness of diffusion-weighted imaging using low and high b-values to detect rectal cancer. Magn Reson Med Sci 5(4):173–177PubMed
84.
go back to reference Rao SX, Zeng MS, Chen CZ, Li RC, Zhang SJ, Xu JM, Hou YY (2008) The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detection. Eur J Radiol 65(2):299–303PubMed Rao SX, Zeng MS, Chen CZ, Li RC, Zhang SJ, Xu JM, Hou YY (2008) The value of diffusion-weighted imaging in combination with T2-weighted imaging for rectal cancer detection. Eur J Radiol 65(2):299–303PubMed
85.
go back to reference Sasaki T, Shinya S, Nakagawa Y, Hisamatsu Y, Sukehiro S, Guiqing Z, Yamamoto F (2007) Diffusion-weighted imaging is a feasible method for screening colorectal cancer: report of a case. Hepatogastroenterology 54(79):1951–1953PubMed Sasaki T, Shinya S, Nakagawa Y, Hisamatsu Y, Sukehiro S, Guiqing Z, Yamamoto F (2007) Diffusion-weighted imaging is a feasible method for screening colorectal cancer: report of a case. Hepatogastroenterology 54(79):1951–1953PubMed
86.
go back to reference Kim SH, Lee JM, Hong SH, Kim GH, Lee JY, Han JK, Choi BI (2009) Locally advanced rectal cancer: added value of diffusion-weighted MR imaging in the evaluation of tumor response to neoadjuvant chemo- and radiation therapy. Radiology 253(1):116–125PubMed Kim SH, Lee JM, Hong SH, Kim GH, Lee JY, Han JK, Choi BI (2009) Locally advanced rectal cancer: added value of diffusion-weighted MR imaging in the evaluation of tumor response to neoadjuvant chemo- and radiation therapy. Radiology 253(1):116–125PubMed
87.
go back to reference Kim CK, Kim SH, Chun HK, Lee WY, Yun SH, Song SY, Choi D, Lim HK, Kim MJ, Lee J, Lee SJ (2006) Preoperative staging of rectal cancer: accuracy of 3-Tesla magnetic resonance imaging. Eur Radiol 16(5):972–980PubMed Kim CK, Kim SH, Chun HK, Lee WY, Yun SH, Song SY, Choi D, Lim HK, Kim MJ, Lee J, Lee SJ (2006) Preoperative staging of rectal cancer: accuracy of 3-Tesla magnetic resonance imaging. Eur Radiol 16(5):972–980PubMed
88.
go back to reference Kim CK, Kim SH, Choi D, Kim MJ, Chun HK, Lee SJ, Lee JM (2007) Comparison between 3-T magnetic resonance imaging and multi-detector row computed tomography for the preoperative evaluation of rectal cancer. J Comput Assist Tomogr 31(6):853–859PubMed Kim CK, Kim SH, Choi D, Kim MJ, Chun HK, Lee SJ, Lee JM (2007) Comparison between 3-T magnetic resonance imaging and multi-detector row computed tomography for the preoperative evaluation of rectal cancer. J Comput Assist Tomogr 31(6):853–859PubMed
89.
go back to reference Chun HK, Choi D, Kim MJ, Lee J, Yun SH, Kim SH, Lee SJ, Kim CK (2006) Preoperative staging of rectal cancer: comparison of 3-T high-field MRI and endorectal sonography. AJR Am J Roentgenol 187(6):1557–1562PubMed Chun HK, Choi D, Kim MJ, Lee J, Yun SH, Kim SH, Lee SJ, Kim CK (2006) Preoperative staging of rectal cancer: comparison of 3-T high-field MRI and endorectal sonography. AJR Am J Roentgenol 187(6):1557–1562PubMed
90.
go back to reference Winter L, Bruhn H, Langrehr J, Neuhaus P, Felix R, Hänninen LE (2007) Magnetic resonance imaging in suspected rectal cancer: determining tumor localization, stage, and sphincter-saving resectability at 3-Tesla-sustained high resolution. Acta Radiol 48(4):379–387PubMed Winter L, Bruhn H, Langrehr J, Neuhaus P, Felix R, Hänninen LE (2007) Magnetic resonance imaging in suspected rectal cancer: determining tumor localization, stage, and sphincter-saving resectability at 3-Tesla-sustained high resolution. Acta Radiol 48(4):379–387PubMed
91.
go back to reference Kim SH, Lee JM, Lee MW, Kim GH, Han JK, Choi BI (2008) Diagnostic accuracy of 3.0-Tesla rectal magnetic resonance imaging in preoperative local staging of primary rectal cancer. Invest Radiol 43(8):587–593PubMed Kim SH, Lee JM, Lee MW, Kim GH, Han JK, Choi BI (2008) Diagnostic accuracy of 3.0-Tesla rectal magnetic resonance imaging in preoperative local staging of primary rectal cancer. Invest Radiol 43(8):587–593PubMed
92.
go back to reference Muthusamy VR, Chang KJ (2007) Optimal methods for staging rectal cancer. Clin Cancer Res 13(22 Pt 2):6877s–6884sPubMed Muthusamy VR, Chang KJ (2007) Optimal methods for staging rectal cancer. Clin Cancer Res 13(22 Pt 2):6877s–6884sPubMed
93.
go back to reference Dinter DJ, Hofheinz RD, Hartel M, Kaehler GF, Neff W, Diehl SJ (2008) Preoperative staging of rectal tumors: comparison of endorectal ultrasound, hydro-CT, and high-resolution endorectal MRI. Onkologie 31(5):230–235PubMed Dinter DJ, Hofheinz RD, Hartel M, Kaehler GF, Neff W, Diehl SJ (2008) Preoperative staging of rectal tumors: comparison of endorectal ultrasound, hydro-CT, and high-resolution endorectal MRI. Onkologie 31(5):230–235PubMed
94.
go back to reference Akin O, Nessar G, Agildere AM, Aydog G (2004) Preoperative local staging of rectal cancer with endorectal MR imaging: comparison with histopathologic findings. Clin Imaging 28(6):432–438PubMed Akin O, Nessar G, Agildere AM, Aydog G (2004) Preoperative local staging of rectal cancer with endorectal MR imaging: comparison with histopathologic findings. Clin Imaging 28(6):432–438PubMed
95.
go back to reference Torricelli P (2007) Rectal cancer staging. Surg Oncol 16(Suppl 1):S49–S50PubMed Torricelli P (2007) Rectal cancer staging. Surg Oncol 16(Suppl 1):S49–S50PubMed
96.
go back to reference Donmez FY, Tunaci M, Yekeler E, Balik E, Tunaci A, Acunas G (2008) Effect of using endorectal coil in preoperative staging of rectal carcinomas by pelvic MR imaging. Eur J Radiol 67(1):139–145PubMed Donmez FY, Tunaci M, Yekeler E, Balik E, Tunaci A, Acunas G (2008) Effect of using endorectal coil in preoperative staging of rectal carcinomas by pelvic MR imaging. Eur J Radiol 67(1):139–145PubMed
97.
go back to reference Karantanas AH, Yarmenitis S, Papanikolaou N, Gourtsoyiannis N (2007) Preoperative imaging staging of rectal cancer. Dig Dis 25(1):20–32PubMed Karantanas AH, Yarmenitis S, Papanikolaou N, Gourtsoyiannis N (2007) Preoperative imaging staging of rectal cancer. Dig Dis 25(1):20–32PubMed
98.
go back to reference Iafrate F, Laghi A, Paolantonio P, Rengo M, Mercantini P, Ferri M, Ziparo V, Passariello R (2006) Preoperative staging of rectal cancer with MR Imaging: correlation with surgical and histopathologic findings. Radiographics 26(3):701–714PubMed Iafrate F, Laghi A, Paolantonio P, Rengo M, Mercantini P, Ferri M, Ziparo V, Passariello R (2006) Preoperative staging of rectal cancer with MR Imaging: correlation with surgical and histopathologic findings. Radiographics 26(3):701–714PubMed
99.
go back to reference Torkzad MR, Suzuki C, Tanaka S, Palmer G, Holm T, Blomqvist L (2008) Morphological assessment of the interface between tumor and neighboring tissues, by magnetic resonance imaging, before and after radiotherapy in patients with locally advanced rectal cancer. Acta Radiol 49(10):1099–1103PubMed Torkzad MR, Suzuki C, Tanaka S, Palmer G, Holm T, Blomqvist L (2008) Morphological assessment of the interface between tumor and neighboring tissues, by magnetic resonance imaging, before and after radiotherapy in patients with locally advanced rectal cancer. Acta Radiol 49(10):1099–1103PubMed
100.
go back to reference Torkzad MR, Lindholm J, Martling A, Cedermark B, Glimelius B, Blomqvist L (2007) MRI after preoperative radiotherapy for rectal cancer; correlation with histopathology and the role of volumetry. Eur Radiol 17(6):1566–1573PubMed Torkzad MR, Lindholm J, Martling A, Cedermark B, Glimelius B, Blomqvist L (2007) MRI after preoperative radiotherapy for rectal cancer; correlation with histopathology and the role of volumetry. Eur Radiol 17(6):1566–1573PubMed
101.
go back to reference Allen SD, Padhani AR, Dzik-Jurasz AS, Glynne-Jones R (2007) Rectal carcinoma: MRI with histologic correlation before and after chemoradiation therapy. AJR Am J Roentgenol 188(2):442–451PubMed Allen SD, Padhani AR, Dzik-Jurasz AS, Glynne-Jones R (2007) Rectal carcinoma: MRI with histologic correlation before and after chemoradiation therapy. AJR Am J Roentgenol 188(2):442–451PubMed
102.
go back to reference Dworak O, Keilholz L, Hoffmann A (1997) Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 12(1):19–23PubMed Dworak O, Keilholz L, Hoffmann A (1997) Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 12(1):19–23PubMed
103.
go back to reference Rödel C, Martus P, Papadoupolos T, Füzesi L, Klimpfinger M, Fietkau R, Liersch T, Hohenberger W, Raab W, Sauer R, Wittekind C (2005) Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 23(34):8688–8696PubMed Rödel C, Martus P, Papadoupolos T, Füzesi L, Klimpfinger M, Fietkau R, Liersch T, Hohenberger W, Raab W, Sauer R, Wittekind C (2005) Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 23(34):8688–8696PubMed
104.
go back to reference Jacques AE, Rockall AG, Alijani M, Hughes J, Babar S, Aleong JA, Cottrill C, Dorudi S, Reznek RH (2007) MRI demonstration of the effect of neoadjuvant radiotherapy on rectal carcinoma. Acta Oncol 46(7):989–995PubMed Jacques AE, Rockall AG, Alijani M, Hughes J, Babar S, Aleong JA, Cottrill C, Dorudi S, Reznek RH (2007) MRI demonstration of the effect of neoadjuvant radiotherapy on rectal carcinoma. Acta Oncol 46(7):989–995PubMed
105.
go back to reference Wieder HA, Rosenberg R, Lordick F, Geinitz H, Beer A, Becker K, Woertler K, Dobritz M, Siewert JR, Rummeny EJ, Stollfuss JC (2007) Rectal cancer: MR imaging before neoadjuvant chemotherapy and radiation therapy for prediction of tumor-free circumferential resection margins and long-term survival. Radiology 243(3):744–751PubMed Wieder HA, Rosenberg R, Lordick F, Geinitz H, Beer A, Becker K, Woertler K, Dobritz M, Siewert JR, Rummeny EJ, Stollfuss JC (2007) Rectal cancer: MR imaging before neoadjuvant chemotherapy and radiation therapy for prediction of tumor-free circumferential resection margins and long-term survival. Radiology 243(3):744–751PubMed
106.
go back to reference Kuo LJ, Liu MC, Jian JJ, Horng CF, Cheng TI, Chen CM, Fang WT, Chung YL (2007) Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? Ann Surg Oncol 14(10):2766–2772PubMed Kuo LJ, Liu MC, Jian JJ, Horng CF, Cheng TI, Chen CM, Fang WT, Chung YL (2007) Is final TNM staging a predictor for survival in locally advanced rectal cancer after preoperative chemoradiation therapy? Ann Surg Oncol 14(10):2766–2772PubMed
107.
go back to reference Wotherspoon AC (2006) Pathological assessment of rectal carcinoma after preoperative therapy. Colorectal Dis 8(Suppl 3):37–39PubMed Wotherspoon AC (2006) Pathological assessment of rectal carcinoma after preoperative therapy. Colorectal Dis 8(Suppl 3):37–39PubMed
108.
go back to reference Vliegen RF, Beets GL, Lammering G, Dresen RC, Rutten HJ, Kessels AG, Oei TK, de Bruïne AP, van Engelshoven JM, Beets-Tan RG (2008) Mesorectal fascia invasion after neoadjuvant chemotherapy and radiation therapy for locally advanced rectal cancer: accuracy of MR imaging for prediction. Radiology 246(2):454–462PubMed Vliegen RF, Beets GL, Lammering G, Dresen RC, Rutten HJ, Kessels AG, Oei TK, de Bruïne AP, van Engelshoven JM, Beets-Tan RG (2008) Mesorectal fascia invasion after neoadjuvant chemotherapy and radiation therapy for locally advanced rectal cancer: accuracy of MR imaging for prediction. Radiology 246(2):454–462PubMed
109.
go back to reference Kulkarni T, Gollins S, Maw A, Hobson P, Byrne R, Widdowson D (2008) Magnetic resonance imaging in rectal cancer downstaged using neoadjuvant chemoradiation: accuracy of prediction of tumour stage and circumferential resection margin status. Colorectal Dis 10(5):479–489PubMed Kulkarni T, Gollins S, Maw A, Hobson P, Byrne R, Widdowson D (2008) Magnetic resonance imaging in rectal cancer downstaged using neoadjuvant chemoradiation: accuracy of prediction of tumour stage and circumferential resection margin status. Colorectal Dis 10(5):479–489PubMed
110.
go back to reference Barbaro B, Fiorucci C, Tebala C, Valentini V, Gambacorta MA, Vecchio FM, Rizzo G, Coco C, Crucitti A, Ratto C, Bonomo L (2009) Locally advanced rectal cancer: MR imaging in prediction of response after preoperative chemotherapy and radiation therapy. Radiology 250(3):730–739PubMed Barbaro B, Fiorucci C, Tebala C, Valentini V, Gambacorta MA, Vecchio FM, Rizzo G, Coco C, Crucitti A, Ratto C, Bonomo L (2009) Locally advanced rectal cancer: MR imaging in prediction of response after preoperative chemotherapy and radiation therapy. Radiology 250(3):730–739PubMed
111.
go back to reference Dresen RC, Beets GL, Rutten HJ, Engelen SM, Lahaye MJ, Vliegen RF, de Bruïne AP, Kessels AG, Lammering G, Beets-Tan RG (2009) Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part I. Are we able to predict tumor confined to the rectal wall? Radiology 252(1):71–80PubMed Dresen RC, Beets GL, Rutten HJ, Engelen SM, Lahaye MJ, Vliegen RF, de Bruïne AP, Kessels AG, Lammering G, Beets-Tan RG (2009) Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part I. Are we able to predict tumor confined to the rectal wall? Radiology 252(1):71–80PubMed
112.
go back to reference Rudisch A, Kremser C, Judmaier W, Zunterer H, DeVries AF (2005) Dynamic contrast-enhanced magnetic resonance imaging: a non-invasive method to evaluate significant differences between malignant and normal tissue. Eur J Radiol 53(3):514–519PubMed Rudisch A, Kremser C, Judmaier W, Zunterer H, DeVries AF (2005) Dynamic contrast-enhanced magnetic resonance imaging: a non-invasive method to evaluate significant differences between malignant and normal tissue. Eur J Radiol 53(3):514–519PubMed
113.
go back to reference Atkin G, Taylor NJ, Daley FM, Stirling JJ, Richman P, Glynne-Jones R, d'Arcy JA, Collins DJ, Padhani AR (2006) Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis. Br J Surg 93(8):992–1000PubMed Atkin G, Taylor NJ, Daley FM, Stirling JJ, Richman P, Glynne-Jones R, d'Arcy JA, Collins DJ, Padhani AR (2006) Dynamic contrast-enhanced magnetic resonance imaging is a poor measure of rectal cancer angiogenesis. Br J Surg 93(8):992–1000PubMed
114.
go back to reference Dinter DJ, Horisberger K, Zechmann C, Wenz F, Brade J, Willeke F, Neff KW, Schoenberg SO, Hofheinz RD (2009) Can dynamic MR imaging predict response in patients with rectal cancer undergoing cetuximab-based neoadjuvant chemoradiation? Onkologie 32(3):86–93PubMed Dinter DJ, Horisberger K, Zechmann C, Wenz F, Brade J, Willeke F, Neff KW, Schoenberg SO, Hofheinz RD (2009) Can dynamic MR imaging predict response in patients with rectal cancer undergoing cetuximab-based neoadjuvant chemoradiation? Onkologie 32(3):86–93PubMed
115.
go back to reference Myerson RJ, Hunt SR (2007) Conservative alternatives to extirpative surgery for rectal cancer. Clin Oncol (R Coll Radiol) 19(9):682–686 Myerson RJ, Hunt SR (2007) Conservative alternatives to extirpative surgery for rectal cancer. Clin Oncol (R Coll Radiol) 19(9):682–686
116.
go back to reference Beets-Tan RG, Beets GL (2003) Rectal cancer: how accurate can imaging predict the T stage and the circumferential resection margin? Int J Colorectal Dis 18(5):385–391PubMed Beets-Tan RG, Beets GL (2003) Rectal cancer: how accurate can imaging predict the T stage and the circumferential resection margin? Int J Colorectal Dis 18(5):385–391PubMed
117.
go back to reference Kim SH, Lee JM, Park HS, Eun HW, Han JK, Choi BI (2009) Accuracy of MRI for predicting the circumferential resection margin, mesorectal fascia invasion, and tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer. J Magn Reson Imaging 29(5):1093–1101PubMed Kim SH, Lee JM, Park HS, Eun HW, Han JK, Choi BI (2009) Accuracy of MRI for predicting the circumferential resection margin, mesorectal fascia invasion, and tumor response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer. J Magn Reson Imaging 29(5):1093–1101PubMed
118.
go back to reference Hughes R, Harrison M, Glynne-Jones R (2010) Could a wait and see policy be justified in T3/4 rectal cancers after chemo-radiotherapy? Acta Oncol 49(3):378–381PubMed Hughes R, Harrison M, Glynne-Jones R (2010) Could a wait and see policy be justified in T3/4 rectal cancers after chemo-radiotherapy? Acta Oncol 49(3):378–381PubMed
119.
go back to reference Idrees K, Paty PB (2006) Early rectal cancer: transanal excision or radical surgery? Adv Surg 40:239–248PubMed Idrees K, Paty PB (2006) Early rectal cancer: transanal excision or radical surgery? Adv Surg 40:239–248PubMed
120.
go back to reference Srinivasaiah N, Joseph B, Mackey P, Monson JR (2008) How do we manage early rectal cancer? A national questionnaire survey among members of the ACPGBI after the preliminary results of the MRC CR07/NCIC CO16 randomized trial. Colorectal Dis 10(4):357–362PubMed Srinivasaiah N, Joseph B, Mackey P, Monson JR (2008) How do we manage early rectal cancer? A national questionnaire survey among members of the ACPGBI after the preliminary results of the MRC CR07/NCIC CO16 randomized trial. Colorectal Dis 10(4):357–362PubMed
121.
go back to reference Baatrup G, Endreseth BH, Isaksen V, Kjellmo A, Tveit KM, Nesbakken A (2009) Preoperative staging and treatment options in T1 rectal adenocarcinoma. Acta Oncol 48(3):328–342PubMed Baatrup G, Endreseth BH, Isaksen V, Kjellmo A, Tveit KM, Nesbakken A (2009) Preoperative staging and treatment options in T1 rectal adenocarcinoma. Acta Oncol 48(3):328–342PubMed
122.
go back to reference Doornebosch PG, Tollenaar RA, De Graaf EJ (2009) Is the increasing role of transanal endoscopic microsurgery in curation for T1 rectal cancer justified? A systematic review. Acta Oncol 48(3):343–353PubMed Doornebosch PG, Tollenaar RA, De Graaf EJ (2009) Is the increasing role of transanal endoscopic microsurgery in curation for T1 rectal cancer justified? A systematic review. Acta Oncol 48(3):343–353PubMed
123.
go back to reference Khani MH, Smedh K, Kraaz W (2007) Is the circumferential resection margin a predictor of local recurrence after preoperative radiotherapy and optimal surgery for rectal carcinoma? Colorectal Dis 9(8):706–712PubMed Khani MH, Smedh K, Kraaz W (2007) Is the circumferential resection margin a predictor of local recurrence after preoperative radiotherapy and optimal surgery for rectal carcinoma? Colorectal Dis 9(8):706–712PubMed
124.
go back to reference Stollfuss JC, Becker K, Sendler A, Seidl S, Settles M, Auer F, Beer A, Rummeny EJ, Woertler K (2006) Rectal carcinoma: high-spatial-resolution MR imaging and T2 quantification in rectal cancer specimens. Radiology 241(1):132–141PubMed Stollfuss JC, Becker K, Sendler A, Seidl S, Settles M, Auer F, Beer A, Rummeny EJ, Woertler K (2006) Rectal carcinoma: high-spatial-resolution MR imaging and T2 quantification in rectal cancer specimens. Radiology 241(1):132–141PubMed
125.
go back to reference Koh DM, Chau I, Tait D, Wotherspoon A, Cunningham D, Brown G (2008) Evaluating mesorectal lymph nodes in rectal cancer before and after neoadjuvant chemoradiation using thin-section T2-weighted magnetic resonance imaging. Int J Radiat Oncol Biol Phys 71(2):456–461PubMed Koh DM, Chau I, Tait D, Wotherspoon A, Cunningham D, Brown G (2008) Evaluating mesorectal lymph nodes in rectal cancer before and after neoadjuvant chemoradiation using thin-section T2-weighted magnetic resonance imaging. Int J Radiat Oncol Biol Phys 71(2):456–461PubMed
126.
go back to reference Suppiah A, Hunter IA, Cowley J, Garimella V, Cast J, Hartley JE, Monson JR (2009) Magnetic resonance imaging accuracy in assessing tumour down-staging following chemoradiation in rectal cancer. Colorectal Dis 11(3):249–253PubMed Suppiah A, Hunter IA, Cowley J, Garimella V, Cast J, Hartley JE, Monson JR (2009) Magnetic resonance imaging accuracy in assessing tumour down-staging following chemoradiation in rectal cancer. Colorectal Dis 11(3):249–253PubMed
127.
go back to reference Lahaye MJ, Beets GL, Engelen SM, Kessels AG, de Bruïne AP, Kwee HW, van Engelshoven JM, van de Velde CJ, Beets-Tan RG (2009) Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part II. What are the criteria to predict involved lymph nodes? Radiology 252(1):81–91PubMed Lahaye MJ, Beets GL, Engelen SM, Kessels AG, de Bruïne AP, Kwee HW, van Engelshoven JM, van de Velde CJ, Beets-Tan RG (2009) Locally advanced rectal cancer: MR imaging for restaging after neoadjuvant radiation therapy with concomitant chemotherapy. Part II. What are the criteria to predict involved lymph nodes? Radiology 252(1):81–91PubMed
128.
go back to reference Johnston DF, Lawrence KM, Sizer BF, Arulampalam TH, Motson RW, Dove E, Lacey N (2009) Locally advanced rectal cancer: histopathological correlation and predictive accuracy of serial MRI after neoadjuvant chemotherapy. Br J Radiol 82(976):332–336PubMed Johnston DF, Lawrence KM, Sizer BF, Arulampalam TH, Motson RW, Dove E, Lacey N (2009) Locally advanced rectal cancer: histopathological correlation and predictive accuracy of serial MRI after neoadjuvant chemotherapy. Br J Radiol 82(976):332–336PubMed
129.
go back to reference Chen CC, Lee RC, Lin JK, Wang LW, Yang SH (2005) How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy? Dis Colon Rectum 48(4):722–728PubMed Chen CC, Lee RC, Lin JK, Wang LW, Yang SH (2005) How accurate is magnetic resonance imaging in restaging rectal cancer in patients receiving preoperative combined chemoradiotherapy? Dis Colon Rectum 48(4):722–728PubMed
130.
go back to reference O'Neill BD, Brown G, Heald RJ, Cunningham D, Tait DM (2007) Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer. Lancet Oncol 8(7):625–633PubMed O'Neill BD, Brown G, Heald RJ, Cunningham D, Tait DM (2007) Non-operative treatment after neoadjuvant chemoradiotherapy for rectal cancer. Lancet Oncol 8(7):625–633PubMed
131.
go back to reference Dahlberg M, Glimelius B, Påhlman L (1999) Changing strategy for rectal cancer is associated with improved outcome. Br J Surg 86(3):379–384PubMed Dahlberg M, Glimelius B, Påhlman L (1999) Changing strategy for rectal cancer is associated with improved outcome. Br J Surg 86(3):379–384PubMed
132.
go back to reference Burden C, Rose D, Daniels IR (2005) Bowel cancer: the outcome is improving. J R Soc Promot Health 125(6):255–258PubMed Burden C, Rose D, Daniels IR (2005) Bowel cancer: the outcome is improving. J R Soc Promot Health 125(6):255–258PubMed
133.
go back to reference Daniels IR, Fisher SE, Heald RJ, Moran BJ (2007) Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence. Colorectal Dis 9(4):290–301PubMed Daniels IR, Fisher SE, Heald RJ, Moran BJ (2007) Accurate staging, selective preoperative therapy and optimal surgery improves outcome in rectal cancer: a review of the recent evidence. Colorectal Dis 9(4):290–301PubMed
134.
go back to reference Messiou C, Chalmers AG, Boyle K, Wilson D, Sagar P (2008) Pre-operative MR assessment of recurrent rectal cancer. Br J Radiol 81(966):468–473PubMed Messiou C, Chalmers AG, Boyle K, Wilson D, Sagar P (2008) Pre-operative MR assessment of recurrent rectal cancer. Br J Radiol 81(966):468–473PubMed
135.
go back to reference Miucin-Vukadinović I, Kozić D, Adić O, Radovanović Z, Breberina M, Bokorov B (2008) Rectal cancer: possibilities of MRI in detection of local recurrence. Med Pregl 61(3–4):157–163PubMed Miucin-Vukadinović I, Kozić D, Adić O, Radovanović Z, Breberina M, Bokorov B (2008) Rectal cancer: possibilities of MRI in detection of local recurrence. Med Pregl 61(3–4):157–163PubMed
136.
go back to reference Höcht S, Mann B, Germer CT, Hammad R, Siegmann A, Wiegel T, Buhr HJ, Hinkelbein W (2004) Pelvic sidewall involvement in recurrent rectal cancer. Int J Colorectal Dis 19(2):108–113PubMed Höcht S, Mann B, Germer CT, Hammad R, Siegmann A, Wiegel T, Buhr HJ, Hinkelbein W (2004) Pelvic sidewall involvement in recurrent rectal cancer. Int J Colorectal Dis 19(2):108–113PubMed
137.
go back to reference Syk E, Torkzad MR, Blomqvist L, Ljungqvist O, Glimelius B (2006) Radiological findings do not support lateral residual tumour as a major cause of local recurrence of rectal cancer. Br J Surg 93(1):113–119PubMed Syk E, Torkzad MR, Blomqvist L, Ljungqvist O, Glimelius B (2006) Radiological findings do not support lateral residual tumour as a major cause of local recurrence of rectal cancer. Br J Surg 93(1):113–119PubMed
138.
go back to reference Syk E, Torkzad MR, Blomqvist L, Nilsson PJ, Glimelius B (2008) Local recurrence in rectal cancer: anatomic localization and effect on radiation target. Int J Radiat Oncol Biol Phys 72(3):658–664PubMed Syk E, Torkzad MR, Blomqvist L, Nilsson PJ, Glimelius B (2008) Local recurrence in rectal cancer: anatomic localization and effect on radiation target. Int J Radiat Oncol Biol Phys 72(3):658–664PubMed
139.
go back to reference Titu LV, Nicholson AA, Hartley JE, Breen DJ, Monson JR (2006) Routine follow-up by magnetic resonance imaging does not improve detection of resectable local recurrences from colorectal cancer. Ann Surg 243(3):348–352PubMedPubMedCentral Titu LV, Nicholson AA, Hartley JE, Breen DJ, Monson JR (2006) Routine follow-up by magnetic resonance imaging does not improve detection of resectable local recurrences from colorectal cancer. Ann Surg 243(3):348–352PubMedPubMedCentral
140.
go back to reference Schaefer O, Langer M (2007) Detection of recurrent rectal cancer with CT, MRI and PET/CT. Eur Radiol 17(8):2044–2054PubMed Schaefer O, Langer M (2007) Detection of recurrent rectal cancer with CT, MRI and PET/CT. Eur Radiol 17(8):2044–2054PubMed
141.
go back to reference Moran B, Brown G, Cunningham D, Daniels I, Heald R, Quirke P, Sebag-Montefiore D (2008) Clarifying the TNM staging of rectal cancer in the context of modern imaging and neo-adjuvant treatment: ‘y’‘u’ and ‘p’ need ‘mr’ and ‘ct’. Colorectal Dis 10(3):242–243PubMed Moran B, Brown G, Cunningham D, Daniels I, Heald R, Quirke P, Sebag-Montefiore D (2008) Clarifying the TNM staging of rectal cancer in the context of modern imaging and neo-adjuvant treatment: ‘y’‘u’ and ‘p’ need ‘mr’ and ‘ct’. Colorectal Dis 10(3):242–243PubMed
Metadata
Title
Magnetic resonance imaging (MRI) in rectal cancer: a comprehensive review
Authors
Michael R. Torkzad
Lars Påhlman
Bengt Glimelius
Publication date
01-09-2010
Publisher
Springer Berlin Heidelberg
Published in
Insights into Imaging / Issue 4/2010
Electronic ISSN: 1869-4101
DOI
https://doi.org/10.1007/s13244-010-0037-4

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