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The Journal of Obstetrics and Gynecology of India

Published in:

01-06-2013 | Original Article

Placental Growth Factor: As an Early Second Trimester Predictive Marker for Preeclampsia in Normal and High-Risk Pregnancies in a Turkish Population

Authors: Necmiye Dover, Hacer C. Gulerman, Sevki Celen, Serkan Kahyaoglu, Okan Yenicesu

Published in: The Journal of Obstetrics and Gynecology of India | Issue 3/2013

Abstract

Objective

Placental growth factor (PlGF) is an angiogenetic factor and inducts the development of preeclampsia in a hypoxic environment. In this study, we examined maternal blood PlGF levels in a pregnant population between 16 and 19 weeks of gestation for determining the prospective value for early diagnosis of preeclampsia as a screening test.

Materials and Methods

In this prospective cross-sectional study, 114 nulliparous normotensive pregnant women were selected for the control group and 34 patients who have chronic hypertension or had a medical history of hypertensive disorders in previous pregnancies were selected for the study group.

Results

In the study group, the risk of preeclampsia increased 3.2 times when compared with the control with a confidence interval of 95 %. The cut-off value for PlGF for discriminating preeclamptic and non-preeclamptic patients was found to be 62.5 pg/ml.

Conclusion

Patients with a medical history of hypertensive disorders and low PIGF levels in early second trimester have an increased risk for preeclampsia.

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Title: Placental Growth Factor: As an Early Second Trimester Predictive Marker for Preeclampsia in Normal and High-Risk Pregnancies in a Turkish Population
Authors: Necmiye Dover
Hacer C. Gulerman
Sevki Celen
Serkan Kahyaoglu
Okan Yenicesu
Publication date: 01-06-2013
Publisher: Springer India
Published in: The Journal of Obstetrics and Gynecology of India / Issue 3/2013
Print ISSN: 0971-9202
Electronic ISSN: 0975-6434
DOI: https://doi.org/10.1007/s13224-012-0279-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Placental Growth Factor: As an Early Second Trimester Predictive Marker for Preeclampsia in Normal and High-Risk Pregnancies in a Turkish Population

Abstract

Objective

Materials and Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and Methods

Results

Conclusion

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