Top

Published in:

01-06-2011

A community-based approach to translational research addressing breast cancer disparities

Authors: Karen Hye-cheon Kim Yeary, PhD, Mondi Mason, PhD, MPH, Jerome Turner, BS, Thomas Kieber-Emmons, PhD, Marie Chow, PhD, R. Jean Hine, PhD, Ronda Henry-Tillman, MD, Paul Greene, PhD

Published in: Translational Behavioral Medicine | Issue 2/2011

Abstract

Disparities in breast cancer survival rates suggest that biological processes contribute. Translational research addressing health disparities would benefit from using a community-based participatory approach (CBPR) to examine biological processes commonly seen as the proximal causes of illness as well as behavioral and social-ecological “causes of the causes” within an integrated conceptual framework. This paper describes a CBPR study that explored perceptions regarding breast cancer relevant behaviors, and the application of the study’s results to develop translational research. Data from eight focus groups of African American (n = 29) and Caucasian women (n = 27) were analyzed, using the framework of the social-ecological model. Nutrition and physical activity were valued over screening and research participation. Treatment of illness was emphasized over prevention. Women’s perspectives are presented within a framework that facilitated the collaborative development of translational research to examine associations among biological, behavioral, and societal processes contributing to disparities.

American Cancer Society. (2006). Cancer facts and figures 2006. Atlanta: American Cancer Society.

Ghafoor, A., Jemal, A., Cokkinides, V., et al. (2002). Cancer statistics for African Americans. CA: A Cancer Journal for Clinicians, 52, 326–341.CrossRef

Polite, B. N., & Olopade, O. I. (2005). Breast cancer and race: a rising tide does not lift all boats equally. Perspectives in Biology and Medicine, 48, S166–S175.PubMed

Krieger, N. (2002). Is breast cancer a disease of affluence, poverty, or both? The case of African American women. American Journal of Public Health, 92, 611–613.PubMedCrossRef

Campbell, J. B. (2002). Breast cancer-race, ethnicity, and survival: a literature review. Breast Cancer Research and Treatment, 74, 187–192.PubMedCrossRef

Gerend, M. A., & Pai, M. (2008). Social determinants of black–white disparities in breast cancer mortality: a review. Cancer Epidemiology, Biomarkers & Prevention, 17, 2913–2923.CrossRef

McKenzie, F., & Jeffreys, M. (2009). Do lifestyle or social factors explain ethnic/racial inequalities in breast cancer survival? Epidemiologic Reviews, 31, 52–66.PubMedCrossRef

McCullough, M. L., Feigelson, H. S., Diver, W. R., Patel, A. V., Thun, M. J., & Calle, E. E. (2005). Risk factors for fatal breast cancer in African-American women and White women in a large US prospective cohort. American Journal of Epidemiology, 162, 734–742.PubMedCrossRef

Coughlin, S. S., Leadbetter, S., Richards, T., & Sabatino, S. A. (2008). Contextual analysis of breast and cervical cancer screening and factors associated with health care access among United States women, 2002. Social Science & Medicine, 66, 260–275.CrossRef

10.

Coughlin, S. S., Thompson, T. D., Hall, H. I., Logan, P., & Uhler, R. J. (2002). Breast and cervical carcinoma screening practices among women in rural and nonrural areas of the United States, 1998–1999. Cancer, 94, 2801–2812.PubMedCrossRef

11.

Calle, E. E., Flanders, W. D., Thun, M. J., & Martin, L. M. (1993). Demographic predictors of mammography and Pap smear screening in US women. American Journal of Public Health, 83, 53–60.PubMed

12.

Ward, E., Jemal, A., Cokkinides, V., Singh, G. K., Cardinez, C., Ghafoor, A., et al. (2004). Cancer disparities by race/ethnicity and socioeconomic status. CA: A Cancer Journal for Clinicians, 54, 78–93.CrossRef

13.

Shavers, V. L., & Brown, M. L. (2002). Racial and ethnic disparities in the receipt of cancer treatment. Journal of the National Cancer Institute, 94, 334–357.PubMed

14.

Michels, K., et al. (2003). Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health Study. Diabetes Care, 26, 1752–1758.PubMedCrossRef

15.

Muti, P., et al. (2002). Fasting glucose is a risk factor for breast cancer: a prospective study. Cancer Epidemiol Biomarkers Prev, 11, 1361–1368.PubMed

16.

Pasanisi, P., Berrino, F., De Petris, M., Venturelli, E., Mastroianni, A., & Panico, S. (2006). Metabolic syndrome as a prognostic factor for breast cancer recurrences. International Journal of Cancer, 119, 236–238.CrossRef

17.

Sinagra, D., Amato, C., Scarpilta, A. M., Brigandi, M., Amato, M., Saura, G., et al. (2002). Metabolic syndrome and breast cancer risk. European Review for Medical and Pharmacological Sciences, 6, 55–59.PubMed

18.

Stoll, B. (2002). Upper abdominal obesity, insulin resistance and breast cancer risk. International Journal of Obesity and Related Metabolic Disorders, 26, 747–753.PubMedCrossRef

19.

Goodwin, P., et al. (2002). Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. Journal of Clinical Oncology, 20, 42–51.PubMedCrossRef

20.

Bozcuk, H., et al. (2004). A simple and accurate prediction model to estimate the intrahospital mortality risk of hospitalised cancer patients. International Journal of Clinical Practice, 58, 1014–1019.PubMedCrossRef

21.

Holmes, M. D., & Willett, W. C. (2004). Does diet affect breast cancer risk? Breast Cancer Research, 6, 170–178.PubMedCrossRef

22.

Key, T., et al. (2003). Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. Journal of the National Cancer Institute, 95, 1218–1226.PubMedCrossRef

23.

Calle, E., Rodriguez, C., et al. (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. The New England Journal of Medicine, 348, 1625–1638.PubMedCrossRef

24.

Smith, S., Clark, L., Cooper, R., Daniels, S., Kumanyika, S., Ofili, E., et al. (2005). Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Obesity, Metabolic Syndrome, and Hypertension Writing Group. Circulation, 111, E134–E139.PubMedCrossRef

25.

Wamala, S. P., Lynch, J., Horsten, M., Mittleman, M. A., Schenck-Gustafsson, K., & Orth-Gomer, K. (1999). Education and the metabolic syndrome in women. Diabetes Care, 22, 1999–2003.PubMedCrossRef

26.

Stelmach, W., Kaczmarczyk-Chalas, K., Bielecki, W., & Drygas, W. (2005). How education, income, control over life and life style contribute to risk factors for cardiovascular disease among adults in a post-communist country. Public Health, 119, 498–508.PubMedCrossRef

27.

Ford, E. S. (2005). Prevalence, of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S. Diabetes Care, 28, 2745–2749.PubMedCrossRef

28.

Ford, E. S., Giles, W. H., & Dietz, W. H. (2002). Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. Journal of the American Medical Association, 287, 356–359.PubMedCrossRef

29.

McKinlay, J. B., & Marceau, L. D. (2000). To boldly go. American Journal of Public Health, 90, 25–33.PubMedCrossRef

30.

Rose, G. (1992). The strategy of preventive medicine. New York: Oxford University Press.

31.

McLeroy, K. R., Bibeau, D., Steckler, A., & Glanz, K. (1988). An ecological perspective on health promotion programs. Health Education Quarterly, 15, 351–377.PubMed

32.

Abrams, D. B. (2006). Applying, transdisciplinary research strategies to understanding and eliminating health disparities. Health Education & Behavior, 33, 515–531.CrossRef

33.

Mabry, P. L., Olster, D. H., Morgan, G. D., & Abrams, D. B. (2008). Interdisciplinarity and systems science to improve population health: a view from the NIH Office of Behavioral and Social Sciences Research. American Journal of Preventive Medicine, 35, S211–S224.PubMedCrossRef

34.

Yancey, A. K., Ortega, A. N., & Kumanyika, S. K. (2006). Effective recruitment and retention of minority research participants. Annual Review of Public Health, 27, 1–28.PubMedCrossRef

35.

Murthy, V. H., Krumholz, H. M., & Gross, C. P. (2004). Participation in cancer clinical trials: race-, sex-, and age-based disparities. Journal of the American Medical Association, 291, 2720–2726.PubMedCrossRef

36.

Svensson, C. K. (1989). Representation of American blacks in clinical trials of new drugs. Journal of the American Medical Association, 261, 263–265.PubMedCrossRef

37.

Heiat, A., Gross, C. P., & Krumholz, H. M. (2002). Representation of the elderly, women, and minorities in heart failure clinical trials. Archives of Internal Medicine, 162, 1682–1688.PubMedCrossRef

38.

Durant, R. W., Davis, R. B., St George, D. M., Williams, I. C., Blumenthal, C., & Corbie-Smith, G. M. (2007). Participation in research studies: factors associated with failing to meet minority recruitment goals. Annals of Epidemiology, 17, 634–642.PubMedCrossRef

39.

Lerman, C., Hughes, C., Benkendorf, J. L., Biesecker, B., Kerner, J., Willison, J., et al. (1999). Racial differences in testing motivation and psychological distress following pretest education for BRCA1 gene testing. Cancer Epidemiology, Biomarkers and Prevention, 8, 361–367.PubMed

40.

Sanner, J. E., & Frazier, L. (2007). Factors that influence characteristics of genetic biobanks. Journal of Nursing Scholarship, 39, 25–29.PubMedCrossRef

41.

Viswanathan, M., Ammerman, A., Eng, E., Garlehner, G., Lohr, K. N., Griffith, D., et al. (2004). Community-based participatory research: assessing the evidence. Evidence Report-Technology Assessment (Summary), 99, 1–8.

42.

Shalowitz, M. U., Isacco, A., Barquin, N., Clark-Kauffman, E., Delger, P., Nelson, D., et al. (2009). Community-based participatory research: a review of the literature with strategies for community engagement. Journal of Developmental and Behavioral Pediatrics, 30, 350–361.PubMedCrossRef

43.

Coburn, A. F., MacKinney, A. C., McBride, T. D., Mueller, K. J., Slifkin, R. T., and Wakefield, M. K. (2007). Choosing rural definitions: implications for health policy. Rural Policy Research Institute Health Panel, Keith Mueller (Chair).

44.

McCloskey, A. H., Woolwich, J., & Holahan, D. (1995). Reforming the health care system: state profiles 1995 (pp. 20–104). Washington: American Association of Retired Persons.

45.

Pamuk, E., Maduc, D., Heck, H., Reuben, C., and Lochner, K. (1998). Socioeconomic status and health chartbook. Health, United States. Hyattsville, MD: National Center for Health Statistics.

46.

Lower Mississippi Delta Nutrition Intervention Research Consortium. (1997). In G. Harrison (Ed.), Nutrition and health status in the Lower Mississippi Delta of Arkansas, Louisiana, Mississippi: a review of existing data. Rockville: Westat Inc.

47.

Anderson, R. N., Kochanek, K. D., & Murphy, S. L. (1997). Report on final mortality statistics, 1995. Monthly vital statistics report 45 (pp. 1–80). Hyattsville: National Center for Health Statistics.

48.

Ruff, C. C., Alexander, I. M., & McKie, C. (2005). The use of focus group methodology in health disparities research. Nursing Outlook, 53, 134–140.PubMedCrossRef

49.

Krueger, R. A., & Casey, M. A. (2000). Focus groups: A practical guide for applied research. Thousand Oaks: Sage Publications.

50.

Denzin, L. K., & Lincoln, Y. S. (2000). Handbook of qualitative research. Thousand Oaks: Sage Publications.

51.

Glaser, B., & Strauss, A. (1967). The discovery of grounded theory. Chicago: Aldine.

52.

Lincoln, Y. S., & Guba, E. G. (1985). Naturalistic inquiry. Newbury Park: Sage Publications.

Title: A community-based approach to translational research addressing breast cancer disparities
Authors: Karen Hye-cheon Kim Yeary, PhD
Mondi Mason, PhD, MPH
Jerome Turner, BS
Thomas Kieber-Emmons, PhD
Marie Chow, PhD
R. Jean Hine, PhD
Ronda Henry-Tillman, MD
Paul Greene, PhD
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: Translational Behavioral Medicine / Issue 2/2011
Print ISSN: 1869-6716
Electronic ISSN: 1613-9860
DOI: https://doi.org/10.1007/s13142-011-0018-2

2024 ASCO Annual Meeting

Springer Medicine

A community-based approach to translational research addressing breast cancer disparities

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2011

What are successful recruitment and retention strategies for underserved populations? Examining physical activity interventions in primary care and community settings

News from NIH: Global Health

Sustainability of evidence-based community-based physical activity programs for older adults: lessons from Active for Life

Community trial of insecticide-treated bed net use promotion in southern Ghana: the Net Use Intervention study

Interventions for families affected by HIV

Promoting culturally targeted chronic disease prevention research through an adapted participatory research approach: The Qassim-Stanford Universities project