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Nuclear Medicine and Molecular Imaging
Published in: Nuclear Medicine and Molecular Imaging 1/2011

01-03-2011 | Review

Current Molecular Imaging Positron Emitting Radiotracers in Oncology

Authors: Aizhi Zhu, Hyunsuk Shim

Published in: Nuclear Medicine and Molecular Imaging | Issue 1/2011

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Abstract

Molecular imaging is one of the fastest growing areas of medical imaging. Positron emission tomography (PET) has been widely used in the clinical management of patients with cancer. Nuclear imaging provides biological information at the cellular, subcellular, and molecular level in living subjects with non-invasive procedures. In particular, PET imaging takes advantage of traditional diagnostic imaging techniques and introduces positron-emitting probes to determine the expression of indicative molecular targets at different stages of cancer. 18F-fluorodeoxyglucose (18F-FDG), the only FDA approved oncological PET tracer, has been widely utilized in cancer diagnosis, staging, restaging, and even monitoring response to therapy; however, 18F-FDG is not a tumor-specific PET tracer. Over the last decade, many promising tumor-specific PET tracers have been developed and evaluated in preclinical and clinical studies. This review provides an overview of the current non-18F-FDG PET tracers in oncology that have been developed based on tumor characteristics such as increased metabolism, hyperproliferation, angiogenesis, hypoxia, apoptosis, and tumor-specific antigens and surface receptors.
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Metadata
Title
Current Molecular Imaging Positron Emitting Radiotracers in Oncology
Authors
Aizhi Zhu
Hyunsuk Shim
Publication date
01-03-2011
Publisher
Springer-Verlag
Published in
Nuclear Medicine and Molecular Imaging / Issue 1/2011
Print ISSN: 1869-3474
Electronic ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-011-0075-y

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