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Translational Stroke Research
Published in: Translational Stroke Research 4/2013

01-08-2013 | Original Article

The Effects of Estrogen in Ischemic Stroke

Authors: Edward C. Koellhoffer, Louise D. McCullough

Published in: Translational Stroke Research | Issue 4/2013

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Abstract

Stroke is a leading cause of death and the most common cause of long-term disability in the USA. Women have a lower incidence of stroke compared with men throughout most of the lifespan which has been ascribed to protective effects of gonadal steroids, most notably estrogen. Due to the lower stroke incidence observed in pre-menopausal women and robust preclinical evidence of neuroprotective and anti-inflammatory properties of estrogen, researchers have focused on the potential benefits of hormones to reduce ischemic brain injury. However, as women age, they are disproportionately affected by stroke, coincident with the loss of estrogen with menopause. The risk of stroke in elderly women exceeds that of men and it is clear that in some settings estrogen can have pro-inflammatory effects. This review will focus on estrogen and inflammation and its interaction with aging.
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Metadata
Title
The Effects of Estrogen in Ischemic Stroke
Authors
Edward C. Koellhoffer
Louise D. McCullough
Publication date
01-08-2013
Publisher
Springer US
Published in
Translational Stroke Research / Issue 4/2013
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-012-0230-5

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