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Published in:

01-09-2012 | Original Article

Bone Marrow Chimeras in the Study of Experimental Stroke

Authors: Xian Nan Tang, Zhen Zheng, Midori A. Yenari

Published in: Translational Stroke Research | Issue 3/2012

Abstract

Inflammation is known to contribute to stroke evolution, and poststroke immune responses have been documented to emanate from the brain via microglia. However, circulating immune cells are increasingly recognized to play a significant role as well. Recent work has demonstrated the importance of the peripheral circulation and stroke pathogenesis. Understanding how the peripheral circulation contributes to ischemic brain injury may reveal important therapeutic targets and strategies. The use of bone marrow chimeras can be a useful tool in understanding the relative contributions of brain resident and peripheral inflammatory responses.

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Title: Bone Marrow Chimeras in the Study of Experimental Stroke
Authors: Xian Nan Tang
Zhen Zheng
Midori A. Yenari
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: Translational Stroke Research / Issue 3/2012
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-012-0169-6

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Bone Marrow Chimeras in the Study of Experimental Stroke

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