Skip to main content
Top
Published in: Translational Stroke Research 1/2011

01-03-2011 | Editorial

Resolving the Negative Data Publication Dilemma in Translational Stroke Research

Authors: Paul A. Lapchak, John H. Zhang

Published in: Translational Stroke Research | Issue 1/2011

Login to get access

Excerpt

“Learn from yesterday, live for today, hope for tomorrow. The important thing is not to stop questioning” ∼∼Albert Einstein (physicist, Nobel Prize in 1921. 1879–1955).
Literature
1.
go back to reference Turner R, Jickling G, Sharp F. Are underlying assumptions of current animal models of human stroke correct: From STAIRS to high hurdles? Transl Stroke Res. 2011;2(1). Turner R, Jickling G, Sharp F. Are underlying assumptions of current animal models of human stroke correct: From STAIRS to high hurdles? Transl Stroke Res. 2011;2(1).
2.
go back to reference Ning M, Lo EH. Opportunities and challenges in omics. Transl Stroke Res. 2010;1(4):233–7.CrossRef Ning M, Lo EH. Opportunities and challenges in omics. Transl Stroke Res. 2010;1(4):233–7.CrossRef
3.
go back to reference Jickling GC, Zhan X, Ander BP, Turner RJ, Stamova B, Xu H, et al. Genome response to tissue plasminogen activator in experimental ischemic stroke. BMC Genomics. 2010;11:254.CrossRefPubMed Jickling GC, Zhan X, Ander BP, Turner RJ, Stamova B, Xu H, et al. Genome response to tissue plasminogen activator in experimental ischemic stroke. BMC Genomics. 2010;11:254.CrossRefPubMed
4.
go back to reference Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, et al. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 2010;30(1):92–101.CrossRefPubMed Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, et al. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 2010;30(1):92–101.CrossRefPubMed
5.
go back to reference Lapchak PA, Schubert DR, Maher PA. Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. J Neurochem. 2011;116(1):122–131. Lapchak PA, Schubert DR, Maher PA. Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke. J Neurochem. 2011;116(1):122–131.
6.
go back to reference Lapchak PA, KcKim, JM. CeeTox™ analysis of CNB-001 a novel curcumin-based neurotrophic/neuroprotective lead compound to treat stroke: Comparison with NXY-059 and Radicut. Transl Stroke Res. 2011;2(1). Lapchak PA, KcKim, JM. CeeTox™ analysis of CNB-001 a novel curcumin-based neurotrophic/neuroprotective lead compound to treat stroke: Comparison with NXY-059 and Radicut. Transl Stroke Res. 2011;2(1).
7.
go back to reference Maher P, Salgado KF, Zivin JA, Lapchak PA. A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Res. 2007;1173:117–25.CrossRefPubMed Maher P, Salgado KF, Zivin JA, Lapchak PA. A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Res. 2007;1173:117–25.CrossRefPubMed
8.
go back to reference Adeoye O, Clark JF, Khatri P, Wagner KR, Zuccarello M, Pyne-Geithman GJ. Do current animal models of intracerebral hemorrhage mirror the human pathology? Transl Stroke Res. 2011;2(1). Adeoye O, Clark JF, Khatri P, Wagner KR, Zuccarello M, Pyne-Geithman GJ. Do current animal models of intracerebral hemorrhage mirror the human pathology? Transl Stroke Res. 2011;2(1).
9.
go back to reference Lapchak PA. Translational stroke research using a rabbit embolic stroke model: A correlative analysis hypothesis for novel therapy development. Transl Stroke Res. 2010;1(2):96–107 [Perspective Review].CrossRefPubMed Lapchak PA. Translational stroke research using a rabbit embolic stroke model: A correlative analysis hypothesis for novel therapy development. Transl Stroke Res. 2010;1(2):96–107 [Perspective Review].CrossRefPubMed
10.
go back to reference Brown AT, Skinner RD, Flores R, Hennings L, Borrelli MJ, Lowery J, et al. Stroke location and brain function in an embolic rabbit stroke model. J Vasc Interv Radiol. 2010;21(6):903–9.CrossRefPubMed Brown AT, Skinner RD, Flores R, Hennings L, Borrelli MJ, Lowery J, et al. Stroke location and brain function in an embolic rabbit stroke model. J Vasc Interv Radiol. 2010;21(6):903–9.CrossRefPubMed
11.
go back to reference Sugawara T, Ayer R, Jadhav V, Zhang JH. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 2008;167(2):327–34.CrossRefPubMed Sugawara T, Ayer R, Jadhav V, Zhang JH. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 2008;167(2):327–34.CrossRefPubMed
12.
go back to reference Hartman R, Lekic T, Rojas H, Tang J, Zhang JH. Assessing functional outcomes following intracerebral hemorrhage in rats. Brain Res. 2009;1280:148–57.CrossRefPubMed Hartman R, Lekic T, Rojas H, Tang J, Zhang JH. Assessing functional outcomes following intracerebral hemorrhage in rats. Brain Res. 2009;1280:148–57.CrossRefPubMed
13.
go back to reference Moskowitz MA, Lo EH, Iadecola C. The science of stroke: Mechanisms in search of treatments. Neuron. 2010;67(2):181–98.CrossRefPubMed Moskowitz MA, Lo EH, Iadecola C. The science of stroke: Mechanisms in search of treatments. Neuron. 2010;67(2):181–98.CrossRefPubMed
14.
go back to reference Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: Neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009;276(17):4644–52.CrossRefPubMed Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: Neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009;276(17):4644–52.CrossRefPubMed
15.
go back to reference Saver JL, Gornbein J. Treatment effects for which shift or binary analyses are advantageous in acute stroke trials. Neurology. 2009;72(15):1310–15.CrossRefPubMed Saver JL, Gornbein J. Treatment effects for which shift or binary analyses are advantageous in acute stroke trials. Neurology. 2009;72(15):1310–15.CrossRefPubMed
16.
go back to reference Saver JL. Novel end point analytic techniques and interpreting shifts across the entire range of outcome scales in acute stroke trials. Stroke. 2007;38(11):3055–62.CrossRefPubMed Saver JL. Novel end point analytic techniques and interpreting shifts across the entire range of outcome scales in acute stroke trials. Stroke. 2007;38(11):3055–62.CrossRefPubMed
17.
go back to reference Mandava P, Kent TA. A method to determine stroke trial success using multidimensional pooled control functions. Stroke. 2009;40(5):1803–10.CrossRefPubMed Mandava P, Kent TA. A method to determine stroke trial success using multidimensional pooled control functions. Stroke. 2009;40(5):1803–10.CrossRefPubMed
18.
go back to reference Kellner CP, Connolly Jr ES. Neuroprotective strategies for intracerebral hemorrhage: Trials and translation. Stroke. 2010;41(10 Suppl):S99–102.CrossRefPubMed Kellner CP, Connolly Jr ES. Neuroprotective strategies for intracerebral hemorrhage: Trials and translation. Stroke. 2010;41(10 Suppl):S99–102.CrossRefPubMed
19.
go back to reference Dirnagl U, Lauritzen M. Fighting publication bias: Introducing the Negative Results section. J Cereb Blood Flow Metab. 2010;30(7):1263–4.CrossRefPubMed Dirnagl U, Lauritzen M. Fighting publication bias: Introducing the Negative Results section. J Cereb Blood Flow Metab. 2010;30(7):1263–4.CrossRefPubMed
20.
go back to reference Hebert RS, Wright SM, Dittus RS, Elasy TA. Prominent medical journals often provide insufficient information to assess the validity of studies with negative results. J Negat Results Biomed. 2002;1:1.CrossRefPubMed Hebert RS, Wright SM, Dittus RS, Elasy TA. Prominent medical journals often provide insufficient information to assess the validity of studies with negative results. J Negat Results Biomed. 2002;1:1.CrossRefPubMed
21.
go back to reference Probst JC. Prisoners’ dilemma: The importance of negative results. Fam Med. 2006;38(10):742–3.PubMed Probst JC. Prisoners’ dilemma: The importance of negative results. Fam Med. 2006;38(10):742–3.PubMed
22.
go back to reference Littner Y, Mimouni FB, Dollberg S, Mandel D. Negative results and impact factor: A lesson from neonatology. Arch Pediatr Adolesc Med. 2005;159(11):1036–7.CrossRefPubMed Littner Y, Mimouni FB, Dollberg S, Mandel D. Negative results and impact factor: A lesson from neonatology. Arch Pediatr Adolesc Med. 2005;159(11):1036–7.CrossRefPubMed
23.
go back to reference Fanelli D. Do pressures to publish increase scientists’ bias? An empirical support from US States data. PLoS ONE. 2010;5(4):e10271.CrossRefPubMed Fanelli D. Do pressures to publish increase scientists’ bias? An empirical support from US States data. PLoS ONE. 2010;5(4):e10271.CrossRefPubMed
24.
go back to reference NINDS. Tissue plasminogen activator for acute ischemic stroke. The national institute of neurological disorders and stroke rt-PA stroke study group. N Engl J Med. 1995;333(24):1581–7.CrossRef NINDS. Tissue plasminogen activator for acute ischemic stroke. The national institute of neurological disorders and stroke rt-PA stroke study group. N Engl J Med. 1995;333(24):1581–7.CrossRef
25.
go back to reference Belayev L, Khoutorova L, Atkins KD, Eady TN, Hong S, Lu Y, Obenaus A, Bazan NG. Docosahexaenoic acid therapy of experimental ischemic stroke. Transl Stroke Res. 2011;2(1). Belayev L, Khoutorova L, Atkins KD, Eady TN, Hong S, Lu Y, Obenaus A, Bazan NG. Docosahexaenoic acid therapy of experimental ischemic stroke. Transl Stroke Res. 2011;2(1).
26.
go back to reference Lapchak PA, Araujo DM, Zivin JA. Comparison of tenecteplase with alteplase on clinical rating scores following small clot embolic strokes in rabbits. Exp Neurol. 2004;185(1):154–9.CrossRefPubMed Lapchak PA, Araujo DM, Zivin JA. Comparison of tenecteplase with alteplase on clinical rating scores following small clot embolic strokes in rabbits. Exp Neurol. 2004;185(1):154–9.CrossRefPubMed
27.
go back to reference Guan W, Zhao G, Xu C. A combined treatment with taurine and intra-arterial thrombolysis in an embolic model of stroke in rats: Increased neuroprotective efficacy and extended therapeutic time window. Transl Stroke Res. 2011;2(1). Guan W, Zhao G, Xu C. A combined treatment with taurine and intra-arterial thrombolysis in an embolic model of stroke in rats: Increased neuroprotective efficacy and extended therapeutic time window. Transl Stroke Res. 2011;2(1).
28.
go back to reference Hoffmann A, Bredno J, Wendland M, Derugin N, Ohara P, Wintermark M. High and Low molecular weight fluorescein Isothiocyanate (FITC)–dextrans to assess blood-brain barrier disruption: Technical considerations. Transl Stroke Res. 2011;2(1). Hoffmann A, Bredno J, Wendland M, Derugin N, Ohara P, Wintermark M. High and Low molecular weight fluorescein Isothiocyanate (FITC)–dextrans to assess blood-brain barrier disruption: Technical considerations. Transl Stroke Res. 2011;2(1).
29.
go back to reference Woitzik J, Hohenstein A, Hecht N, Juettler E, Schilling L. Short period of early reperfusion aggravates blood–brain barrier dysfunction during permanent focal ischemia in rats. Transl Stroke Res. 2011;2(1). Woitzik J, Hohenstein A, Hecht N, Juettler E, Schilling L. Short period of early reperfusion aggravates blood–brain barrier dysfunction during permanent focal ischemia in rats. Transl Stroke Res. 2011;2(1).
30.
go back to reference Dorhout Mees SM RG, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, van Gijn J. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2007;3(CD000277). Dorhout Mees SM RG, Feigin VL, Algra A, van den Bergh WM, Vermeulen M, van Gijn J. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2007;3(CD000277).
31.
go back to reference Murakami K, Koide M, Dumont TM, Russell SR, Tranmer BI, Wellman GC. Subarachnoid hemorrhage induces gliosis and increased expression of the pro-inflammatory cytokine high mobility group box 1 protein. Transl Stroke Res. 2011;2(1). Murakami K, Koide M, Dumont TM, Russell SR, Tranmer BI, Wellman GC. Subarachnoid hemorrhage induces gliosis and increased expression of the pro-inflammatory cytokine high mobility group box 1 protein. Transl Stroke Res. 2011;2(1).
32.
go back to reference Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359(13):1317–29.CrossRefPubMed Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359(13):1317–29.CrossRefPubMed
33.
go back to reference Lyden P, Lu M, Jackson C, Marler J, Kothari R, Brott T, et al. Underlying structure of the national institutes of health stroke scale: Results of a factor analysis. NINDS tPA Stroke Trial Investigators. Stroke. 1999;30(11):2347–54.PubMed Lyden P, Lu M, Jackson C, Marler J, Kothari R, Brott T, et al. Underlying structure of the national institutes of health stroke scale: Results of a factor analysis. NINDS tPA Stroke Trial Investigators. Stroke. 1999;30(11):2347–54.PubMed
34.
go back to reference Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, et al. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med. 2007;357(6):562–71.CrossRefPubMed Shuaib A, Lees KR, Lyden P, Grotta J, Davalos A, Davis SM, et al. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med. 2007;357(6):562–71.CrossRefPubMed
35.
go back to reference Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): A prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol. 2009;8(2):141–50.CrossRefPubMed Hacke W, Furlan AJ, Al-Rawi Y, Davalos A, Fiebach JB, Gruber F, et al. Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): A prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol. 2009;8(2):141–50.CrossRefPubMed
36.
go back to reference Zivin JA, Albers GW, Bornstein N, Chippendale T, Dahlof B, Devlin T, et al. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke. 2009;40(4):1359–64.CrossRefPubMed Zivin JA, Albers GW, Bornstein N, Chippendale T, Dahlof B, Devlin T, et al. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke. 2009;40(4):1359–64.CrossRefPubMed
37.
go back to reference Lampl Y, Zivin JA, Fisher M, Lew R, Welin L, Dahlof B, et al. Infrared laser therapy for ischemic stroke: A new treatment strategy: Results of the NeuroThera effectiveness and safety trial-1 (NEST-1). Stroke. 2007;38(6):1843–9.CrossRefPubMed Lampl Y, Zivin JA, Fisher M, Lew R, Welin L, Dahlof B, et al. Infrared laser therapy for ischemic stroke: A new treatment strategy: Results of the NeuroThera effectiveness and safety trial-1 (NEST-1). Stroke. 2007;38(6):1843–9.CrossRefPubMed
38.
go back to reference Lees KR, Zivin JA, Ashwood T, Davalos A, Davis SM, Diener HC, et al. NXY-059 for acute ischemic stroke. N Engl J Med. 2006;354(6):588–600.CrossRefPubMed Lees KR, Zivin JA, Ashwood T, Davalos A, Davis SM, Diener HC, et al. NXY-059 for acute ischemic stroke. N Engl J Med. 2006;354(6):588–600.CrossRefPubMed
39.
go back to reference Furlan AJ, Eyding D, Albers GW, Al-Rawi Y, Lees KR, Rowley HA, et al. Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): Evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke. 2006;37(5):1227–31.CrossRefPubMed Furlan AJ, Eyding D, Albers GW, Al-Rawi Y, Lees KR, Rowley HA, et al. Dose escalation of desmoteplase for acute ischemic stroke (DEDAS): Evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke. 2006;37(5):1227–31.CrossRefPubMed
40.
go back to reference Bath PM, Gray LJ, Bath AJ, Buchan A, Miyata T, Green AR. Effects of NXY-059 in experimental stroke: An individual animal meta-analysis. Br J Pharmacol. 2009;157(7):1157–71.CrossRefPubMed Bath PM, Gray LJ, Bath AJ, Buchan A, Miyata T, Green AR. Effects of NXY-059 in experimental stroke: An individual animal meta-analysis. Br J Pharmacol. 2009;157(7):1157–71.CrossRefPubMed
42.
go back to reference Lapchak PA. Taking a light approach to treating acute ischemic stroke patients: Transcranial near-infrared laser therapy translational science. Ann Med. 2010;42(8):576–86.CrossRefPubMed Lapchak PA. Taking a light approach to treating acute ischemic stroke patients: Transcranial near-infrared laser therapy translational science. Ann Med. 2010;42(8):576–86.CrossRefPubMed
44.
go back to reference Lapchak PA. A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy? Expert Opin Pharmacother. 2010;11(10):1753–63.CrossRefPubMed Lapchak PA. A critical assessment of edaravone acute ischemic stroke efficacy trials: Is edaravone an effective neuroprotective therapy? Expert Opin Pharmacother. 2010;11(10):1753–63.CrossRefPubMed
Metadata
Title
Resolving the Negative Data Publication Dilemma in Translational Stroke Research
Authors
Paul A. Lapchak
John H. Zhang
Publication date
01-03-2011
Publisher
Springer-Verlag
Published in
Translational Stroke Research / Issue 1/2011
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-010-0057-x

Other articles of this Issue 1/2011

Translational Stroke Research 1/2011 Go to the issue