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Translational Stroke Research
Published in: Translational Stroke Research 4/2010

01-12-2010

MicroRNAs in Cerebral Ischemia

Authors: Kai-Ying Lim, Jia-Hui Chua, Jun-Rong Tan, Priyadharshni Swaminathan, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Peter Tsun-Hon Wong, Kandiah Jeyaseelan

Published in: Translational Stroke Research | Issue 4/2010

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Abstract

Pathogenesis of cerebral ischemia has so far been described in the context of proteins and the pathways that they regulate. The discovery of biomarkers has also been focussed mainly on proteins and to some extent on the mRNAs that encode them. The knowledge on the role of microRNAs in understanding the pathogenesis of cerebral ischemia is still at its infancy. In this study, using rat models subjected to middle cerebral artery occlusion, we have profiled the microRNAs at different reperfusion times (0 to 48 h) to understand the progression of cerebral ischemia. We have also attempted to correlate the expression of microRNAs to treatment with an NMDA antagonist (MK801) and to protein expression with the hope of demonstrating the potential use of microRNAs as early biomarkers of stroke.
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Metadata
Title
MicroRNAs in Cerebral Ischemia
Authors
Kai-Ying Lim
Jia-Hui Chua
Jun-Rong Tan
Priyadharshni Swaminathan
Sugunavathi Sepramaniam
Arunmozhiarasi Armugam
Peter Tsun-Hon Wong
Kandiah Jeyaseelan
Publication date
01-12-2010
Publisher
Springer-Verlag
Published in
Translational Stroke Research / Issue 4/2010
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-010-0035-3

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