Thrombophilia testing in splanchnic venous thrombosis: Decoding a conundrum

Excerpt

We read with great interest the article by Giri et al. analyzing the prevalence of acquired and inherited thrombophilia among Indian patients with non-cirrhotic portal vein thrombosis (PVT) and Budd-Chiari syndrome (BCS). The authors reported that the thrombophilia profile in Indian patients with abdominal vein thrombosis is different as compared to the west with a lower prevalence of prothrombotic conditions in patients with BCS. At least one prothrombotic condition was seen in 46.2% (28.7–63.7) of patients with PVT and 44.9% (37.3–60.7) of patients with BCS. Most common condition seen in patients with PVT was hyperhomocystinemia, whereas, in patients with BCS, protein C deficiency was the most common [1]. This study sheds light on the contentious topic of thrombophilia testing in patients with splanchnic venous thrombosis and ends up generating many questions while answering a few. …