Skip to main content
Top
Published in: Journal of Maxillofacial and Oral Surgery 1/2023

25-08-2021 | Osteomyelitis | Case Report

Arsenic Trioxide-Induced Mandibular Osteomyelitis Associated with Mycotic Infestation: A Case Report

Authors: Stephanie Mrad, Abdallah Menhall, Christian Makary, Joseph Bassil

Published in: Journal of Maxillofacial and Oral Surgery | Issue 1/2023

Login to get access

Abstract

Arsenic trioxide used in endodontic treatments has been shown to cause severe damages to surrounding bone and periodontal tissues. This report describes a case of alveolar osteomyelitis triggered by arsenic trioxide pulp devitalization and associated with mycotic infestation. Following clinical and radiological examinations, the concerned tooth was extracted, bone sequestrum was removed and granulation tissue was debrided. Histopathological biopsy examination, stained with hematoxylin/eosin, Grocott’s silver methenamine and periodic acid-Schiff, confirmed the diagnosis of chemical osteomyelitis associated with fungal infestation. Six months postoperatively, normal bone healing was observed.
Literature
1.
go back to reference Chen G, Sung P-T (2014) Gingival and localized alveolar bone necrosis related to the use of arsenic trioxide paste—two case reports. J Formos Med Assoc 113(3):187–190CrossRef Chen G, Sung P-T (2014) Gingival and localized alveolar bone necrosis related to the use of arsenic trioxide paste—two case reports. J Formos Med Assoc 113(3):187–190CrossRef
2.
go back to reference Bataineh AB, Al-Omari MA, Owais AI (1997) Arsenical necrosis of the jaws. Int Endod J 30(4):283–287CrossRef Bataineh AB, Al-Omari MA, Owais AI (1997) Arsenical necrosis of the jaws. Int Endod J 30(4):283–287CrossRef
3.
go back to reference Yakata H, Azumi T, Kawasaki T, Nakajima T (1985) Extensive osteolysis of the mandible following devitalization of a tooth by arsenic trioxide. J Oral Maxillofac Surg 43(6):462–466CrossRef Yakata H, Azumi T, Kawasaki T, Nakajima T (1985) Extensive osteolysis of the mandible following devitalization of a tooth by arsenic trioxide. J Oral Maxillofac Surg 43(6):462–466CrossRef
4.
go back to reference Smart ER, Barnes IE (1991) Tissue necrosis after using an arsenical endodontic preparation: a case report. Int Endod J 24(5):263–269 Smart ER, Barnes IE (1991) Tissue necrosis after using an arsenical endodontic preparation: a case report. Int Endod J 24(5):263–269
5.
go back to reference Yalçin S, Aybar B, Haznedaroğlu F, Yücel E (2003) Bilateral oroantral fistulas following devitalization of teeth by arsenic trioxide: a case report. J Endod 29(3):205–207CrossRef Yalçin S, Aybar B, Haznedaroğlu F, Yücel E (2003) Bilateral oroantral fistulas following devitalization of teeth by arsenic trioxide: a case report. J Endod 29(3):205–207CrossRef
6.
go back to reference Baur DA, Altay MA, Flores-Hidalgo A, Ort Y, Quereshy FA (2015) Chronic osteomyelitis of the mandible: diagnosis and management—an institution’s experience over 7 years. J Oral Maxillofac Surg 73(4):655–665CrossRef Baur DA, Altay MA, Flores-Hidalgo A, Ort Y, Quereshy FA (2015) Chronic osteomyelitis of the mandible: diagnosis and management—an institution’s experience over 7 years. J Oral Maxillofac Surg 73(4):655–665CrossRef
7.
go back to reference Ozmeriç N (2002) Localized alveolar bone necrosis following the use of an arsenical paste: a case report. Int Endod J 35(3):295–299CrossRef Ozmeriç N (2002) Localized alveolar bone necrosis following the use of an arsenical paste: a case report. Int Endod J 35(3):295–299CrossRef
8.
go back to reference Lu P-C, Wu J-H, Chen C-M, Du J-K (2015) Arsenic trioxide-induced mandibular osteomyelitis. J Oral Maxillofac Surg 73(9):1761–1765CrossRef Lu P-C, Wu J-H, Chen C-M, Du J-K (2015) Arsenic trioxide-induced mandibular osteomyelitis. J Oral Maxillofac Surg 73(9):1761–1765CrossRef
9.
go back to reference Garip H, Salih IM, Sener BC, Göker K, Garip Y (2004) Management of arsenic trioxide necrosis in the maxilla. J Endod 30(10):732–736CrossRef Garip H, Salih IM, Sener BC, Göker K, Garip Y (2004) Management of arsenic trioxide necrosis in the maxilla. J Endod 30(10):732–736CrossRef
Metadata
Title
Arsenic Trioxide-Induced Mandibular Osteomyelitis Associated with Mycotic Infestation: A Case Report
Authors
Stephanie Mrad
Abdallah Menhall
Christian Makary
Joseph Bassil
Publication date
25-08-2021
Publisher
Springer India
Keyword
Osteomyelitis
Published in
Journal of Maxillofacial and Oral Surgery / Issue 1/2023
Print ISSN: 0972-8279
Electronic ISSN: 0974-942X
DOI
https://doi.org/10.1007/s12663-021-01629-7

Other articles of this Issue 1/2023

Journal of Maxillofacial and Oral Surgery 1/2023 Go to the issue