Skip to main content
Top
Published in: Journal of Maxillofacial and Oral Surgery 2/2012

01-06-2012 | Review Paper

OraVerse: Reverses Numbness After Dental Procedures

Author: J. S. Prasanna

Published in: Journal of Maxillofacial and Oral Surgery | Issue 2/2012

Login to get access

Abstract

The lingering numbness that can last anywhere from 3 to 5 h after a routine dental procedure is often an unnecessary, inconvenient hassle. Patients may find that their ability to speak, smile, eat and drink is impaired, and may even have uncontrollable drooling. The effects of local dental anesthetics can now be reversed. That’s because OraVerse, an anesthetic reversal agent, can return the patient to normal sensation and function in about half the time. OraVerse which is U.S. Food and Drug Administration approved is a safe and effective form of phentolamine mesylate, a vasodilator that has been used in several other medical applications since 1952. OraVerse injection – the first and only proven safe and effective product of its kind can quickly reverse the effects of local dental anesthetics, so patient can carry on without impairment of talk, smile and drink after dental procedures. Studies also have shown that there are no known drug interactions and no evident toxicity or contraindications for using OraVerse.
Literature
1.
go back to reference Wynn RL (2009) Phentolamine mesylate-An old medical drug becomes a new dental drug. Gen Dent 57(3):200–202PubMed Wynn RL (2009) Phentolamine mesylate-An old medical drug becomes a new dental drug. Gen Dent 57(3):200–202PubMed
2.
go back to reference Morrow T (2008) OraVerse helps you lose that numbing feeling. Manag Care 17(90):50–51PubMed Morrow T (2008) OraVerse helps you lose that numbing feeling. Manag Care 17(90):50–51PubMed
4.
go back to reference Myklejord DJ (2004) Undiagnosed pheochromocytoma: the anesthesiologist nightmare. Clin Med Res 2(1):59–62PubMedCrossRef Myklejord DJ (2004) Undiagnosed pheochromocytoma: the anesthesiologist nightmare. Clin Med Res 2(1):59–62PubMedCrossRef
6.
go back to reference Hersh EV, Moore PA, Papas AS, Goodson JM, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults. J Am Dent Assoc 139(8):1080–1093PubMed Hersh EV, Moore PA, Papas AS, Goodson JM, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults. J Am Dent Assoc 139(8):1080–1093PubMed
7.
go back to reference Weaver JM (2008) New drugs on the horizon may improve the quality and safety of anesthesia. Anesth Prog 55(2):27–28PubMedCrossRef Weaver JM (2008) New drugs on the horizon may improve the quality and safety of anesthesia. Anesth Prog 55(2):27–28PubMedCrossRef
8.
go back to reference Malamed S (2009) What’s new in local anesthesia? SAAD Dig 25:4–14PubMed Malamed S (2009) What’s new in local anesthesia? SAAD Dig 25:4–14PubMed
9.
go back to reference Gould L, Reddy CV, Chua W (1977) Electrophysiological Properties of Phentolamine in Man. Br Heart J 39(9):939–944PubMedCrossRef Gould L, Reddy CV, Chua W (1977) Electrophysiological Properties of Phentolamine in Man. Br Heart J 39(9):939–944PubMedCrossRef
10.
go back to reference Roberts JR, Krisanda TJ (1989) Accidental Intra-Arterial Injection of Epinephrine Treated With Phentolamine. Ann Emerg Med 18(4):424–425PubMedCrossRef Roberts JR, Krisanda TJ (1989) Accidental Intra-Arterial Injection of Epinephrine Treated With Phentolamine. Ann Emerg Med 18(4):424–425PubMedCrossRef
11.
go back to reference Rutherford B, Zeller JR, Thake D (2009) Local and systemic toxicity of intraoral submucosal injections of phentolamine mesylate (OraVerse). Anesth Prog 56(4):123–127PubMedCrossRef Rutherford B, Zeller JR, Thake D (2009) Local and systemic toxicity of intraoral submucosal injections of phentolamine mesylate (OraVerse). Anesth Prog 56(4):123–127PubMedCrossRef
12.
go back to reference Laviola M, McGavin SK, Freer GA, Plancich G, Woodbury SC, Marinkovich S et al (2008) Randomized study of phentolamine mesylate for reversal of local anesthesia. J Dent Res 87(7):635–639PubMedCrossRef Laviola M, McGavin SK, Freer GA, Plancich G, Woodbury SC, Marinkovich S et al (2008) Randomized study of phentolamine mesylate for reversal of local anesthesia. J Dent Res 87(7):635–639PubMedCrossRef
13.
go back to reference Tavares M, Goodson JM, Studen-Pavlovich D, Yagiela JA, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. J Am Dent Assoc 139(8):1095–1104PubMed Tavares M, Goodson JM, Studen-Pavlovich D, Yagiela JA, Navalta LA, Rogy S et al (2008) Reversal of soft-tissue local anesthesia with phentolamine mesylate in pediatric patients. J Am Dent Assoc 139(8):1095–1104PubMed
14.
go back to reference Malamed SF (2010) Local anesthesia reversal. Dent Today 29(3):65–66PubMed Malamed SF (2010) Local anesthesia reversal. Dent Today 29(3):65–66PubMed
15.
go back to reference Hill JM (1991) Phentolamine mesylate: the antidote for vasopressor extravasation. Crit Care Nurse 11(10):58–61PubMed Hill JM (1991) Phentolamine mesylate: the antidote for vasopressor extravasation. Crit Care Nurse 11(10):58–61PubMed
16.
go back to reference Moore PA, Hersh EV, Papas AS, Goodson JM, Yagiela JA, Rutherford B et al (2008) Pharmaco kinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate. Anesth Prog 55(2):40–48PubMedCrossRef Moore PA, Hersh EV, Papas AS, Goodson JM, Yagiela JA, Rutherford B et al (2008) Pharmaco kinetics of lidocaine with epinephrine following local anesthesia reversal with phentolamine mesylate. Anesth Prog 55(2):40–48PubMedCrossRef
17.
go back to reference Poulet FM, Berardi MR, Halliwell W, Hartman B, Auletta C, Bolte H (2004) Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study. Toxicol Pathol 32(5):558–566PubMedCrossRef Poulet FM, Berardi MR, Halliwell W, Hartman B, Auletta C, Bolte H (2004) Development of hibernomas in rats dosed with phentolamine mesylate during the 24-month carcinogenicity study. Toxicol Pathol 32(5):558–566PubMedCrossRef
18.
go back to reference Hersh EV, Hermann DG, Lamp CJ, Johnson PD, Mac A, fee KA (1995) Assessing the duration of mandibular soft tissue anesthesia. J Am Dent Assoc 126(11):1531–1536PubMed Hersh EV, Hermann DG, Lamp CJ, Johnson PD, Mac A, fee KA (1995) Assessing the duration of mandibular soft tissue anesthesia. J Am Dent Assoc 126(11):1531–1536PubMed
19.
go back to reference Cooper BE (1989) High-dose phentolamine for extravasation of pressors. Clin Pharm 8(10):689PubMed Cooper BE (1989) High-dose phentolamine for extravasation of pressors. Clin Pharm 8(10):689PubMed
20.
go back to reference Mc Cleane GJ (1996) Oral phentolamine mesylate in the treatment of complex regional pain Syndrome. Ulst Med J 65(1):87–88 Mc Cleane GJ (1996) Oral phentolamine mesylate in the treatment of complex regional pain Syndrome. Ulst Med J 65(1):87–88
Metadata
Title
OraVerse: Reverses Numbness After Dental Procedures
Author
J. S. Prasanna
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
Journal of Maxillofacial and Oral Surgery / Issue 2/2012
Print ISSN: 0972-8279
Electronic ISSN: 0974-942X
DOI
https://doi.org/10.1007/s12663-011-0318-6

Other articles of this Issue 2/2012

Journal of Maxillofacial and Oral Surgery 2/2012 Go to the issue