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Published in:

01-01-2010

Anthocyanins: Are They Beneficial in Treating Ethanol Neurotoxicity?

Authors: Gang Chen, Jia Luo

Published in: Neurotoxicity Research | Issue 1/2010

Abstract

Heavy alcohol exposure produces profound damage to the developing central nervous system (CNS) as well as the adult brain. Children with fetal alcohol spectrum disorders (FASD) have a variety of cognitive, behavioral, and neurological impairments. FASD currently represents the leading cause of mental retardation. Excessive alcohol consumption is associated with Wernicke–Korsakoff syndrome (WKS) and neurodegeneration in the adult brain. Although the cellular/molecular mechanism underlying ethanol’s neurotoxicity has not been fully understood, it is generally believed that oxidative stress plays an important role. Identification of neuroprotective agents that can ameliorate ethanol neurotoxicity is an important step for developing preventive/therapeutic strategies. Targeting ethanol-induced oxidative stress using natural antioxidants is an attractive approach. Anthocyanins, a large subgroup of flavonoids present in many vegetables and fruits, are safe and potent antioxidants. They exhibit diverse potential health benefits including cardioprotection, anti-atherosclerotic activity, anti-cancer, anti-diabetic, and anti-inflammation properties. Anthocyanins can cross the blood–brain barrier and distribute in the CNS. Recent studies indicate that anthocyanins represent novel neuroprotective agents and may be beneficial in ameliorating ethanol neurotoxicity. In this review, we discuss the evidence and potential of anthocyanins in alleviating ethanol-induced damage to the CNS. Furthermore, we discuss possible underlying mechanisms as well as future research approaches necessary to establish the therapeutic role of anthocyanins.

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Title: Anthocyanins: Are They Beneficial in Treating Ethanol Neurotoxicity?
Authors: Gang Chen
Jia Luo
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: Neurotoxicity Research / Issue 1/2010
Print ISSN: 1029-8428
Electronic ISSN: 1476-3524
DOI: https://doi.org/10.1007/s12640-009-9083-4

2024 ASCO Annual Meeting

Springer Medicine

Anthocyanins: Are They Beneficial in Treating Ethanol Neurotoxicity?

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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Other articles of this Issue 1/2010

Combination Treatment with Ethyl Pyruvate and Aspirin Enhances Neuroprotection in the Postischemic Brain

Biapigenin Modulates the Activity of the Adenine Nucleotide Translocator in Isolated Rat Brain Mitochondria

Oxidized Low-Density Lipoprotein-Induced Matrix Metalloproteinase-9 Expression via PKC-δ/p42/p44 MAPK/Elk-1 Cascade in Brain Astrocytes

The Role of Zinc in the Modulation of Neuronal Proliferation and Apoptosis

Injectable Hydrogels Providing Sustained Delivery of Vascular Endothelial Growth Factor are Neuroprotective in a Rat Model of Huntington’s Disease

Restoration of Nigrostriatal Dopamine Neurons in Post-MPTP Treatment by the Novel Multifunctional Brain-Permeable Iron Chelator-Monoamine Oxidase Inhibitor Drug, M30