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Current Breast Cancer Reports
Published in: Current Breast Cancer Reports 4/2021

01-12-2021 | Breast Cancer | Breast Cancer Management During the COVID-19 Pandemic (A Chagpar, Section Editor)

Health-Related Suffering and Palliative Care in Breast Cancer

Authors: M. M. Sunilkumar, Charles G. Finni, A. S. Lijimol, M. R. Rajagopal

Published in: Current Breast Cancer Reports | Issue 4/2021

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Abstract

Purpose of Review

Breast cancer continues to be the most frequently diagnosed cancer in women and the leading cause of cancer death worldwide. By the suffering that it causes in various domains of life, breast cancer seriously impacts the quality of life of affected individuals and causes a major burden of suffering in the community. The objectives of the review were to understand the health-related suffering in patients with breast cancer and to identify the scope of palliative care in improving the quality of life of patients with breast cancer.

Recent Findings

Breast cancer causes suffering in physical, psychological, social, financial, and spiritual domains of the lives of the patient and family. Management of breast cancer with surgery, chemotherapy, and radiation could have adverse effects, such as pain, nausea and vomiting, fatigue, shortness of breath, depression, and constipation. Both cancer and its treatment can impact the psychosocial and spiritual well-being of the patient and family members. Integrating palliative care into existing breast cancer treatment programs seems to be the best approach to diminish these sufferings.

Summary

In addition to pain and other physical symptoms, breast cancer can cause major psychological, social, and spiritual suffering. In the context of developing countries, out-of-pocket expenditure can cause major financial destruction which can impact generations. Integration of palliative care to breast cancer treatment is essential.
Literature
1.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.CrossRef
2.
Addressing the Global Burden of Breast Cancer [Internet]. National Cancer Institute. 2017 [cited 2019 Apr 18]
3.
Anderson BO. UICC World Cancer Congress 2014: global breast cancer trends. In: Washington: the breast health global initiative; 2014. p. 1–10
4.
Unger-Saldaña K. Challenges to the early diagnosed and treatment of breast cancer in developing countries. World Journal of Clinical Oncology. 2014;5(3):465–77.CrossRef
5.
Ataollahi M, Sharifi J, Paknahad M, Paknahad A. Breast cancer and associated factors: a review. J Med Life. 2015;8(Spec Iss 4):6–11.PubMedPubMedCentral
6.
Agrawal S. Late effects of cancer treatment in breast cancer survivors. South Asian J Cancer. 2014;3(2):112–5.CrossRef
7.
8.
Cherny NI, Paluch-Shimon S, Berner-Wygoda Y. Palliative care: needs of advanced breast cancer patients. Breast Cancer (Dove Med Press). 2018;10:231–43.
9.
• Jain M, Mukherjee K. Economic burden of breast cancer to the households in Punjab, India. International Journal of Medicine and Public Health. 2016;6(1):13–8. (This study from a low middle income country describes economic burden of treatment of breast cancer.)
10.
Rajpal S, Kumar A, Joe W. Economic burden of cancer in India: evidence from cross-sectional nationally representative household survey. PLOS ONE. 2014;13(2):e0193320.CrossRef
11.
Cassel EJ. The nature of suffering and the goals of medicine. N Engl J Med. 1982;306(11):639–45.CrossRef
12.
13.
Galipeau N, Klooster B, Krohe M, Tang DH, Revicki DA, Cella D. Understanding key symptoms, side effects, and impacts of HR+/HER2-advanced breast cancer: qualitative study findings. Journal of patient-reported outcomes. 2019;3(1):10.CrossRef
14.
Satija A, Ahmed SM, Gupta R, Ahmed A, Rana SP, Singh SP, Mishra S, Bhatnagar S. Breast cancer pain management-A review of current & novel therapies. Indian J Med Res. 2014;139(2):216.PubMedPubMedCentral
15.
Wang K, Yee C, Tam S, Drost L, Chan S, Zaki P, Rico V, Ariello K, Dasios M, Lam H, DeAngelis C. Prevalence of pain in patients with breast cancer post-treatment: a systematic review. The Breast. 2018
16.
Rietman JS, Dijkstra PU, Hoekstra HJ, et al. Late morbidity after treatment of breast cancer in relation to daily activities and quality of life: a systematic review. Eur J Surg Oncol. 2003;29(3):229e38.CrossRef
17.
Andersen KG, Duriaud HM, Jensen HE, Kroman N, Kehlet H. Predictive factorsfor the development of persistent pain after breast cancer surgery. Pain. 2015;156(12):2413e22.CrossRef
18.
Poleshuck EL, Katz J, Andrus CH, et al. Risk factors for chronic pain following breast cancer surgery: a prospective study. J Pain. 2006;7(9):626e34.CrossRef
19.
Jung BF, Ahrendt GM, Oaklander AL, Dworkin RH. Neuropathic pain following breast cancer surgery: proposed classification and research update. Pain. 2003;104:1–13.CrossRef
20.
Haroutiunian S, Nikolajsen L, Finnerup NB, Jensen TS. The neuropathic component in persistent postsurgical pain: a systematic literature review. Pain. 2013;154:95–102.CrossRef
21.
Kaur N, Jain A. Postmastectomy chronic pain in breast cancer survivors: an update on definition, pathogenesis, risk Factors, treatment and prevention. Clin Oncol. 2017;2:1300.
22.
Mohamed SA, Abdel-Ghaffar HS, Kamal SM, Fares KM, Hamza HM. Effect of topical morphine on acute and chronic postmastectomy pain: what is the optimum dose? Reg Anesth Pain Med. 2016;41(6):704–10.CrossRef
23.
Tasmuth T, Härtel B, Kalso E. Venlafaxine in neuropathic pain following treatment of breast cancer. Eur J Pain. 2002;6(1):17–24.CrossRef
24.
Kalso E, Tasmuth T, Neuvonen PJ. Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. Pain. 1996;64(2):293–302.CrossRef
25.
Cruto ME, Baricocchi E, Battistella M, Bona F, Giacoletto G, Iacobellis A, et al. Treatment of persistent postmastectomy pain with 5% lidocaine medicated plaster. Minerva Chir. 2015;70(2):147–53.PubMed
26.
• Reyad RM, Omran AF, Abbas DN, Kamel MA, Shaker EH, Tharwat J, Reyad EM, Hashem T. The possible preventive role of pregabalin in postmastectomy pain syndrome: a double-blinded randomized controlled trial. J Pain Symptom Manage. 2019;57(1):1–9. (. This double-blinded randomised controlled trial describes the effect of Pregabalin when used perioperatively can reduce the occurrence of post mastectomy pain.)CrossRef
27.
28.
Murthy V, Chamberlain RS. Menopausal symptoms in young survivors of breast cancer: a growing problem without an ideal solution. Cancer Control. 2012;19(4):317–29.CrossRef
29.
30.
Surveillance Epidemiology and End Results Program. Surveillance, epidemiology and end results program public use CDROM. Bethesda, MD: National Cancer Institute; 2000
31.
32.
33.
34.
Fu MR, Kang Y. Psychosocial impact of living with cancer-related lymphedema. Semin Oncol Nurs. 2013;29:50–60.CrossRef
35.
Fu MR, Rosedale M. Breast cancer survivors’ experiences of lymphedema-related symptoms. J Pain Symptom Manage. 2009;38:849–59.CrossRef
36.
Shih YC, Xu Y, Cormier JN, Giordano S, Ridner SH, Buchholz TA, Perkins GH, Elting LS. Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a 2-year follow-up study. J Clin Oncol. 2009;27:2007–14.CrossRef
37.
38.
Mehnert A, Koch U. Prevalence of acute and post-traumatic stress disorder and comorbid mental disorders in breast cancer patients during primary cancer care: a prospective study. Psychooncology. 2007;16(3):181–8.CrossRef
39.
Ng CG, Mohamed S, Kaur K, Sulaiman AH, Zainal NZ, Taib NA, et al. Perceived distress and its association with depression and anxiety in breast cancer patients. PLoS ONE. 2017;12(3):e0172975.CrossRef
40.
Pan L, Han Y, Sun X, Liu J, Gang H. FDG-PET and other imaging modalities for the evaluation of breast cancer recurrence and metastases: a meta-analysis. J Cancer Res Clin Oncol. 2010;136(7):1007–22.CrossRef
41.
Takahashi T, Hondo M, Nishimura K, Kitani A, Yamano T, Yanagita H, et al. Evaluation of quality of life and psychological response in cancer patients treated with radiotherapy. Radiat Med. 2008;26(7):396–401.CrossRef
42.
Ashbury FD, Findlay H, Reynolds B, McKerracher K. A Canadian survey of cancer patients’ experiences: are their needs being met? J Pain Symptom Manage. 1998;16(5):298–306.CrossRef
43.
Perry S, Kowalski TL, Chang C-H. Quality of life assessment in women with breast cancer: benefits, acceptability and utilization. Health Qual Life Outcomes. 2007;5:24.CrossRef
44.
Costa WA, Monteiro MN, Queiroz JF, Gonçalves AK. Pain and quality of life in breast cancer patients. Clinics (Sao Paulo). 2017;72(12):758–63.CrossRef
45.
Gangane N, Khairkar P, Hurtig A-K, Sebastián MS. Quality of life determinants in breast cancer patients in Central Rural India. Asian Pac J Cancer Prev. 2017;18(12):3325–32.PubMedPubMedCentral
46.
47.
Ristevska-Dimitrovska G, Filov I, Rajchanovska D, Stefanovski P, Dejanova B. Resilience and quality of life in breast cancer patients. Open Access Maced J Med Sci. 2015;3(4):727–31.CrossRef
48.
Molina Y, Yi JC, Martinez-Gutierrez J, Reding KW, Yi-Frazier JP, Rosenberg AR. Resilience among patients across the cancer continuum: diverse perspectives. Clin J Oncol Nurs. 2014;18(1):93–101.CrossRef
49.
50.
Anderson RE, Grant L. What is the value of palliative care provision in low-resource settings? BMJ Glob Health [Internet]. 2017 Feb 14 [cited 2020 Mar 2];2(1).
51.
Zimmermann C, Swami N, Rodin G, Tannock I, Krzyzanowska MK, Leighl NB, et al. Cluster-randomized trial of early palliative care for patients with metastatic cancer. JCO. 2012;30(15_suppl):9003–9003.CrossRef
52.
•• Vanbutsele G, Pardon K, Van Belle S, Surmont V, De Laat M, Colman R, et al. Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial. Lancet Oncol. 2018;19(3):394–404. (This randomised controlled trial describes the importance of integration of palliative care into advanced cancer care for improving the quality of life.)CrossRef
53.
Rugno FC, Paiva BS, Paiva CE. Early integration of palliative care facilitates the discontinuation of anticancer treatment in women with advanced breast or gynecologic cancers. Gynecol Oncol. 2014;135(2):249–54.CrossRef
54.
Metadata
Title
Health-Related Suffering and Palliative Care in Breast Cancer
Authors
M. M. Sunilkumar
Charles G. Finni
A. S. Lijimol
M. R. Rajagopal
Publication date
01-12-2021
Publisher
Springer US
Published in
Current Breast Cancer Reports / Issue 4/2021
Print ISSN: 1943-4588
Electronic ISSN: 1943-4596
DOI
https://doi.org/10.1007/s12609-021-00431-1

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