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01-04-2016 | Review Article

Molecular and cellular events involved in the completion of blastocyst implantation

Authors: Hiromichi Matsumoto, Emiko Fukui, Midori Yoshizawa

Published in: Reproductive Medicine and Biology | Issue 2/2016

Abstract

Blastocyst implantation is an interactive process between the embryo and the uterus. The synchronization of embryonic development with uterine differentiation to a receptive state is essential for a successful pregnancy. The period of uterine receptivity for implantation is limited. Although implantation involves the interaction of numerous signaling molecules, our understanding of the hierarchical mechanisms that coordinate with the embryo–uterine dialogue is not yet sufficient to prevent infertility caused by implantation failure. This review highlights our knowledge on uterine receptivity and hormonal regulation of blastocyst implantation in mice. We also discuss the adhesion molecules, cross-linker proteins, extracellular proteins, and matricellular proteins involved in blastocyst implantation. Furthermore, our recent study reveals that selective proteolysis in an activated blastocyst is associated with the completion of blastocyst implantation after embryo transfer. A better understanding of uterine and blastocyst biology during the peri-implantation period would facilitate further development of reproductive technology.

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Title: Molecular and cellular events involved in the completion of blastocyst implantation
Authors: Hiromichi Matsumoto
Emiko Fukui
Midori Yoshizawa
Publication date: 01-04-2016
Publisher: Springer Japan
Published in: Reproductive Medicine and Biology / Issue 2/2016
Print ISSN: 1445-5781
Electronic ISSN: 1447-0578
DOI: https://doi.org/10.1007/s12522-015-0222-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Molecular and cellular events involved in the completion of blastocyst implantation

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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