Top

ADHD Attention Deficit and Hyperactivity Disorders

Published in:

01-03-2014 | Review Article

The use of actigraphy in the monitoring of methylphenidate versus placebo in ADHD: a meta-analysis

Authors: Franco De Crescenzo, Marco Armando, Luigi Mazzone, Mario Ciliberto, Marco Sciannamea, Caroline Figueroa, Luigi Janiri, Digby Quested, Stefano Vicari

Published in: ADHD Attention Deficit and Hyperactivity Disorders | Issue 1/2014

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder of childhood. There is an increasing need to find objective measures and markers of the disorder in order to assess the efficacy of the therapy and to improve follow-up strategies. Actigraphy is an objective method for recording motor activity and sleep parameters using small, computerized, watch-like devices worn on the body, and it has been used in many clinical trials to assess methylphenidate efficacy and adverse effects in ADHD. Our article aim is to systematically review and perform a meta-analysis of the current evidence on the role of actigraphy in both the detection of changes in activity and in sleep patterns in randomized clinical trials that compared methylphenidate against placebo in the treatment of ADHD. A comprehensive literature search of PubMed/MEDLINE, Scopus, Embase, Cochrane Library, CINHAL and PsycINFO databases was carried out to find randomized clinical trials comparing methylphenidate versus placebo in children with ADHD, using actigraphic measures as an outcome. No start date limit was used and the search was updated until June 2013. The primary outcome measures were ‘total sleep time’ and daytime ‘activity mean’. As secondary outcomes, we analyzed ‘sleep onset latency’, ‘sleep efficiency’ and ‘wake after sleep onset’. Eight articles comprising 393 patients were included in the analysis. Children with ADHD using MPH compared to placebo have a significant difference of a large effect with a diminishing value in the activity mean. For the total sleep time, we found a significant and large effect in the decrease in sleep in MPH group. This study shows that MPH may effectively reduce mean activity in ADHD children, but it may negatively affect total sleep time.

Antle MC, van Diepen HC, Deboer T, Pedram P, Pereira RR, Meijer JH (2012) Methylphenidate modifies the motion of the circadian clock. Neuropsychopharmacology 37(11):2446–2455. doi:10.1038/npp.2012.103 PubMedCrossRef

Boonstra AM, Kooij JJ, Oosterlaan J, Sergeant JA, Buitelaar JK, Van Someren EJ (2007) Hyperactive night and day? Actigraphy studies in adult ADHD: a baseline comparison and the effect of methylphenidate. Sleep 30(4):433–442PubMed

Castells X, Ramos-Quiroga JA, Bosch R, Nogueira M, Casas M (2011) Amphetamines for attention deficit hyperactivity disorder (ADHD) in adults. Cochrane Database Syst Rev 6:CD007813. doi:10.1002/14651858 PubMed

Corkum P, Panton R, Ironside S, Macpherson M, Williams T (2008) Acute impact of immediate release methylphenidate administered three times a day on sleep in children with attention-deficit/hyperactivity disorder. J Pediatr Psychol 33(4):368–379PubMedCrossRef

Cortese S, Faraone SV, Konofal E (2009) Sleep in children with attention-deficit/hyperactivity disorder: meta-analysis of subjective and objective studies. J Am Acad Child Adolesc Psychiatry 48(9):894–908. doi:10.1097/CHI.0b013e3181ac09c9 PubMed

Cortese S, Kelly C, Chabernaud C, Proal E, Di Martino A, Milham MP, Castellanos FX (2012) Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. Am J Psychiatry 169(10):1038–1055. doi:10.1176/appi.ajp.2012.11101521 PubMedCrossRef

Dalsgaard S (2013) Attention-deficit/hyperactivity disorder (ADHD). Eur Child Adolesc Psychiatry 22(Suppl 1):43–48. doi:10.1007/s00787-012-0360-z CrossRef

Dane AV, Schachar RJ, Tannock R (2000) Does actigraphy differentiate ADHD subtypes in a clinical research setting? J Am Acad Child Adolesc Psychiatry 39(6):752–760PubMedCrossRef

Faraone SV, Biederman J, Roe C (2002) Comparative efficacy of Adderall and methylphenidate in attention-deficit/hyperactivity disorder: a meta-analysis. J Clin Psychopharmacol 22(5):468–473PubMedCrossRef

Faraone SV (2012) Understanding the effect size of lisdexamfetamine dimesylate for treating ADHD in children and adults. J Atten Disord 16(2):128–137. doi:10.1177/1087054710379738 PubMedCrossRef

Fowler SC, Zarcone TJ, Levant B (2010) Methylphenidate attenuates rats’ preference for a novel spatial stimulus introduced into a familiar environment: assessment using a force-plate actometer. J Neurosci Methods 189(1):36–43. doi:10.1016/j.jneumeth.2010.03.014 PubMedCentralPubMedCrossRef

Frodl T, Skokauskas N (2012) Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects. Acta Psychiatr Scand 125(2):114–126PubMedCrossRef

Gruber R, Grizenko N, Schwartz G, Ben Amor L, Gauthier J, de Guzman R, Joober R (2006) Sleep and COMT polymorphism in ADHD children: preliminary actigraphic data. J Am Acad Child Adolesc Psychiatry 45(8):982–989PubMedCrossRef

Gruber R, Grizenko N, Schwartz G, Bellingham J, Guzman R, Joober R (2007) Performance on the continuous performance test in children with ADHD is associated with sleep efficiency. Sleep 30(8):1003–1009PubMed

Hagerman RJ, Murphy MA, Wittenberger MD (1988) A controlled trial of stimulant medication in children with the fragile X syndrome. Am J Med Genet 30(1–2):377–392PubMedCrossRef

Hanwella R, Senanayake M, de Silva V (2011) Comparative efficacy and acceptability of methylphenidate and atomoxetine in treatment of attention deficit hyperactivity disorder in children and adolescents: a meta-analysis. BMC Psychiatry 10(11):176. doi:10.1186/1471-244X-11-176 CrossRef

Hare DJ, Jones S, Evershed K (2006) Objective investigation of the sleep–wake cycle in adults with intellectual disabilities and autistic spectrum disorders. J Intellect Disabil Res 50(Pt 10):701–710PubMedCrossRef

Higgins JPT, Green S (2011) Cochrane handbook for systematic reviews of interventions version 5.1.0. The cochrane collaboration. Available from www.cochrane-handbook.org

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560PubMedCrossRef

Huang YS, Tsai MH, Guilleminault C (2011) Pharmacological treatment of ADHD and the short and long term effects on sleep. Curr Pharm Des 17(15):1450–1458PubMedCrossRef

Indic P, Murray G, Maggini C, Amore M, Meschi T, Borghi L, Baldessarini RJ, Salvatore P (2012) Multi-scale motility amplitude associated with suicidal thoughts in major depression. PLoS ONE 7(6):e38761. doi:10.1371/journal.pone.0038761 PubMedCentralPubMedCrossRef

Ironside S, Davidson F, Corkum P (2010) Circadian motor activity affected by stimulant medication in children with attention-deficit/hyperactivity disorder. J Sleep Res 19(4):546–551. doi:10.1111/j.1365-2869.2010.00845.x PubMedCrossRef

Kam HJ, Lee K, Cho SM et al (2011) High-resolution actigraphic analysis of ADHD: a wide range of movement variability observation in three school courses: a pilot study. Healthc Inform Res 17(1):29–37PubMedCentralPubMedCrossRef

Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62(6):593–602PubMedCrossRef

Kessler RC, Angermeyer M, Anthony JC et al (2007) Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization’s World Mental Health Survey Initiative. World Psychiatry 6(3):168–176PubMedCentralPubMed

Kliegman RM, Stanton B, ST Géme J, Schor N, Behrman E (2011) Nelson textbook of pediatrics, 19th edn. Elsevier Saunders, Philadelphia

Konrad K, Günther T, Heinzel-Gutenbrunner M, Herpertz-Dahlmann B (2005) Clinical evaluation of subjective and objective changes in motor activity and attention in children with attention-deficit/hyperactivity disorder in a double-blind methylphenidate trial. J Child Adolesc Psychopharmacol 15(2):180–190PubMedCrossRef

Kooij JJ, Middelkoop HA, van Gils K, Buitelaar JK (2001) The effect of stimulants on nocturnal motor activity and sleep quality in adults with ADHD: an open-label case–control study. J Clin Psychiatry 62(12):952–956PubMedCrossRef

Lahti T, Leppämäki S, Tani P, Partonen T (2009) Actigraphic recording of manic symptoms induced by methylphenidate. Case Rep Med 2009:286430. doi:10.1155/2009/286430 PubMedCentralPubMed

Ludolph AG, Kassubek J, Schmeck K, Glaser C, Wunderlich A, Buck AK, Reske SN, Fegert JM, Mottaghy FM (2008) Dopaminergic dysfunction in attention deficit hyperactivity disorder (ADHD), differences between pharmacologically treated and never treated young adults: a 3, 4-dihdroxy-6-[18F]fluorophenyl-l-alanine PET study. Neuroimage 41(3):718–727PubMedCrossRef

Martin JL, Hakim AD (2011) Wrist actigraphy. Chest 139(6):1514–1527. doi:10.1378/chest.10-1872 PubMedCrossRef

Martín-Martínez D, Casaseca-de-la-Higuera P, Alberola-López S, Andrés-de-Llano J, López-Villalobos JA, Ardura-Fernández J, Alberola-López C (2012) Nonlinear analysis of actigraphic signals for the assessment of the attention-deficit/hyperactivity disorder (ADHD). Med Eng Phys 34(9):1317–1329PubMedCrossRef

Miller LG, Kraft IA (1994) Application of actigraphy in the clinical setting: use in children with attention-deficit hyperactivity disorder. Pharmacotherapy 14(2):219–223PubMed

Mohammadi MR, Mostafavi SA, Keshavarz SA, Eshraghian MR, Hosseinzadeh P, Hosseinzadeh-Attar MJ, Kooshesh SM, Chamari M, Akhondzadeh S (2012) Melatonin effects in methylphenidate treated children with attention deficit hyperactivity disorder: a randomized double blind clinical trial. Iran J Psychiatry 7(2):87–92PubMedCentralPubMed

Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(6):e1000097. doi:10.1371/journal.pmed1000097 PubMedCentralPubMedCrossRef

Mordre M, Groholt B, Sandstad B, Myhre AM (2012) The impact of ADHD symptoms and global impairment in childhood on working disability in mid-adulthood: a 28-year follow-up study using official disability pension records in a high-risk in-patient population. BMC Psychiatry 19(12):174. doi:10.1186/1471-244X-12-174 CrossRef

Morgenthaler T, Alessi C, Friedman L, Owens J, Kapur V, Boehlecke B, Brown T, Chesson A Jr, Coleman J, Lee-Chiong T, Pancer J, Swick TJ (2007) Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: an update for 2007. Sleep 30(4):519–529PubMed

Pelham WE, Gnagy EM, Burrows-Maclean L, Williams A, Fabiano GA, Morrisey SM, Chronis AM, Forehand GL, Nguyen CA, Hoffman MT, Lock TM, Fielbelkorn K, Coles EK, Panahon CJ, Steiner RL, Meichenbaum DL, Onyango AN, Morse GD (2001) Once-a-day Concerta methylphenidate versus three-times-daily methylphenidate in laboratory and natural settings. Pediatrics 107(6):E105PubMedCrossRef

Ritter PS, Marx C, Lewtschenko N, Pfeiffer S, Leopold K, Bauer M, Pfennig A (2012) The characteristics of sleep in patients with manifest bipolar disorder, subjects at high risk of developing the disease and healthy controls. J Neural Transm 119(10):1173–1184PubMedCrossRef

Rosa-Neto P, Lou HC, Cumming P, Pryds O, Karrebaek H, Lunding J, Gjedde A (2005) Methylphenidate-evoked changes in striatal dopamine correlate with inattention and impulsivity in adolescents with attention deficit hyperactivity disorder. Neuroimage 25(3):868–876PubMedCrossRef

Sadeh A (2011) The role and validity of actigraphy in sleep medicine: an update. Sleep Med Rev 15(4):259–267. doi:10.1016/j.smrv.2010.10.001 PubMedCrossRef

Sangal RB, Owens J, Allen AJ, Sutton V, Schuh K, Kelsey D (2006) Effects of atomoxetine and methylphenidate on sleep in children with ADHD. Sleep 29(12):1573–1585PubMed

Schachter HM, Pham B, King J, Langford S, Moher D (2001) How efficacious and safe is short-acting methylphenidate for the treatment of attention-deficit disorder in children and adolescents? A meta-analysis. CMAJ 165(11):1475–1488PubMedCentralPubMed

Schwartz G, Amor LB, Grizenko N, Lageix P, Baron C, Boivin DB, Joober R (2004) Actigraphic monitoring during sleep of children with ADHD on methylphenidate and placebo. J Am Acad Child Adolesc Psychiatry 43(10):1276–1282PubMedCrossRef

Shram MJ, Quinn AM, Chen N, Faulknor J, Luong D, Sellers EM, Endrenyi L (2012) Differences in the in vitro and in vivo pharmacokinetic profiles of once-daily modified-release methylphenidate formulations in Canada: examination of current bioequivalence criteria. Clin Ther 34(5):1170–1178. doi:10.1016/j.clinthera.2012.02.010 PubMedCrossRef

Sonuga-Barke EJ, Brandeis D, Cortese S, Daley D, Ferrin M, Holtmann M, Stevenson J, Danckaerts M, van der Oord S, Döpfner M, Dittmann RW, Simonoff E, Zuddas A, Banaschewski T, Buitelaar J, Coghill D, Hollis C, Konofal E, Lecendreux M, Wong IC, Sergeant J (2013) Nonpharmacological interventions for ADHD: systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. Am J Psychiatry 170(3):275–289. doi:10.1176/appi.ajp.2012.12070991 PubMedCrossRef

St-Amand J, Provencher MD, Bélanger L, Morin CM (2012) Sleep disturbances in bipolar disorder during remission. J Affect Disord 146(1):112–119. doi:10.1016/j.jad.2012.05.057 PubMedCrossRef

Stein MA, Blondis TA, Schnitzler ER, O’Brien T, Fishkin J, Blackwell B, Szumowski E, Roizen NJ (1996) Methylphenidate dosing: twice daily versus three times daily. Pediatrics 98(4 Pt 1):748–756PubMed

Storebø OJ, Gluud C, Winkel P, Simonsen E (2012) Social-skills and parental training plus standard treatment versus standard treatment for children with ADHD: the randomised SOSTRA trial. PLoS ONE 7(6):e37280. doi:10.1371/journal.pone.0037280 PubMedCentralPubMedCrossRef

Swanson JM, Gupta S, Williams L, Agler D, Lerner M, Wigal S (2002) Efficacy of a new pattern of delivery of methylphenidate for the treatment of ADHD: effects on activity level in the classroom and on the playground. J Am Acad Child Adolesc Psychiatry 41(11):1306–1314. Erratum in: J Am Acad Child Adolesc Psychiatry 42(2):260

Taylor E, Döpfner M, Sergeant J, Asherson P, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Rothenberger A, Sonuga-Barke E, Steinhausen HC, Zuddas A (2004) European clinical guidelines for hyperkinetic disorder—first upgrade. Eur Child Adolesc Psychiatry 13(Suppl 1):I7–I30PubMed

Tirosh E, Sadeh A, Munvez R, Lavie P (1993) Effects of methylphenidate on sleep in children with attention-deficient hyperactivity disorder: an activity monitor study. Am J Dis Child 147(12):1313–1315PubMedCrossRef

Uebel H, Albrecht B, Kirov R, Heise A, Döpfner M, Freisleder FJ, Gerber WD, Günter M, Hässler F, Ose C, Poustka F, Fischer R, Banaschewski T, Rothenberger A (2010) What can actigraphy add to the concept of labschool design in clinical trials? Curr Pharm Des 16(22):2434–2442PubMedCrossRef

Van der Oord S, Prins PJ, Oosterlaan J, Emmelkamp PM (2008) Efficacy of methylphenidate, psychosocial treatments and their combination in school-aged children with ADHD: a meta-analysis. Clin Psychol Rev 28(5):783–800PubMedCrossRef

Van Wyk GW, Hazell PL, Kohn MR, Granger RE, Walton RJ (2012) How oppositionality, inattention, and hyperactivity affect response to atomoxetine versus methylphenidate: a pooled meta-analysis. J Atten Disord 16(4):314–324. doi:10.1177/1087054710389989 PubMedCrossRef

Title: The use of actigraphy in the monitoring of methylphenidate versus placebo in ADHD: a meta-analysis
Authors: Franco De Crescenzo
Marco Armando
Luigi Mazzone
Mario Ciliberto
Marco Sciannamea
Caroline Figueroa
Luigi Janiri
Digby Quested
Stefano Vicari
Publication date: 01-03-2014
Publisher: Springer Vienna
Published in: ADHD Attention Deficit and Hyperactivity Disorders / Issue 1/2014
Print ISSN: 1866-6116
Electronic ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-013-0122-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The use of actigraphy in the monitoring of methylphenidate versus placebo in ADHD: a meta-analysis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2014

The concept of instability: a French perspective on the concept of ADHD

Acknowledgement to reviewers 2013

A randomized controlled multicenter trial on the multimodal treatment of adult attention-deficit hyperactivity disorder: enrollment and characteristics of the study sample

Evidence of association between SNAP25 gene and attention deficit hyperactivity disorder in a Latin American sample

Executive functioning in attention-deficit/hyperactivity disorder: questioning the notion of planning deficits with heart rate reactivity

Prognostic factors of improvement in health-related quality of life in atomoxetine-treated children and adolescents with attention-deficit/hyperactivity disorder, based on a pooled analysis