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ADHD Attention Deficit and Hyperactivity Disorders

Published in:

01-09-2012 | Original Article

Anxiety and methylphenidate in attention deficit hyperactivity disorder: a double-blind placebo-drug trial

Authors: Keren Moshe, Avi Karni, Emanuel Tirosh

Published in: ADHD Attention Deficit and Hyperactivity Disorders | Issue 3/2012

Abstract

To examine the relationship between attention and anxiety and the response to methylphenidate in children with attention deficit hyperactivity disorder (ADHD), a total of 57 boys, between the ages of 7–12 years, were assessed for their attention and level of anxiety. Methylphenidate was administered for a week in a randomized double-blind drug/placebo–drug cross-over design. The levels of anxiety were evenly distributed between the inattentive and hyperactive/impulsive types. Anxiety was significantly correlated with the attention as reported by both teachers and parents. The response to methylphenidate was inversely correlated with the reported anxiety level only in boys with the hyperactive/impulsive and combined types. The higher the level of anxiety, the lower level of response to methylphenidate was observed. In the assessment and treatment of children with ADHD, the level of anxiety should be evaluated and taken into account while planning and monitoring treatment regiment.

AACAP Official Action (2007) Practice parameter for the assessment and treatment of children and adolescents with attention deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 46(7):894–921CrossRef

Abikoff H, McGough J, Vitiello B et al (2005) Sequential pharmacotherapy for children with comorbid attention deficit/hyperactivity and anxiety disorders. J Am Acad Child Adolesc Psychiatry 44(5):418–427PubMedCrossRef

Adler AL, Barley RA, Newcorn JH et al (2007) Managing ADHD in children, adolescents, and adults with comorbid anxiety in primary care. J Clin Psychiatry 9(2):129–138

American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn (DSM-IV)). American Psychiatric Association, Washington

Angold S, Costello EJ, Erkanli A (1999) Comorbidity. J Child Psychol Psychiatry 40(1):57–87PubMedCrossRef

Bedard AC, Tannock R (2008) Anxiety, methylphenidate response and working memory in children with ADHD. J Atten Disord 11(5):546–547PubMedCrossRef

Biederman J, Newcorn J, Sprich S (1991) Comorbidity of a attention deficit by hyperactivity disorder with conduct, depressive, anxiety and other disorders. Am J Psychiatry 148(5):564–577PubMed

Biederman J, Hirshleft Becker DR, Rosenbaum JF et al (2001) Further evidence of association between behavioral inhibition and social anxiety in children. Am J Psychiatry 158(10):1673–1679PubMedCrossRef

Brown RT, Amler RW, Freeman WS et al (2005) American Academy of Pediatrics the Committee on Quality Improvement. American Academy of Subcommittee on Attention-Deficit/Hyperactivity disorder. Pediatrics 115(6):e749–e757PubMedCrossRef

Carter S, Syed-Sabir H (2008) How to use a rating score to diagnose attention deficit hyperactivity disorder. Arch Dis Child Educ Pract Ed 93(5):159–162PubMedCrossRef

Daleiden EL, Vasey MV (1997) An informative-processing perspective on childhood anxiety. Clin Psychol Rev 17(4):407–429PubMedCrossRef

Diamond IR, Tannock R, Schachar RJ (1999) Response to methylphenidate in children with ADHD and comorbid anxiety. J Am Acad Child Adolesc Psychiatry 38(4):402–409PubMedCrossRef

DuPaul G, Barkley RA, McMurray MB (1994) Response of children with ADHD to methylphenidate: interaction with internalizing symptoms. J Am Acad Child Adolesc Psychiatry 33(60):894–903PubMedCrossRef

Efron D, Jarman F, Barker M (1997) Methylphenidate versus dexamphetamine in children with attention deficit hyperactivity disorder: a double-blind, crossover trial. Pediatrics 100(6):e6PubMedCrossRef

Eiraldi RB, Power TJ, Nezu CM (1997) Patterns of comorbidity associated with subtypes of attention-deficit/hyperactivity disorder among 6- to 12-year-old children. J Am Acad Child Adolesc Psychiatry 36(4):503–514PubMedCrossRef

Etkin A, Klemenhagen KC, Dudman JT, Rogan MT, Hen R, Kandel ER, Hirsch J (2004) Individual differences in trait anxiety predict the response of the basolateral amygdala to unconsciously processed fearful faces. Neuron 44(6):1043–1055PubMedCrossRef

Ghanizadeh A (2008) Psychiatric comorbidity differences in clinic—referred children and adolescents with ADHD according to the subtypes and gender. J Neurol 24(6):679–684

Goez H, Back-Bennet O, Zelnic N (2007) Differential stimulant response on attention in children with comorbid anxiety and oppositional defiant disorders. J Child Neurol 22(5):538–542PubMedCrossRef

Goyette CH, Conners CK, Ulrich RF (1978) Normative data on revised Conners Parent Teachers Rating Scales. J Abnorm Child Psychol 6(2):221–226PubMedCrossRef

Gray JA (1987) The psychology of fear and stress. Cambridge University Press, New York

Hechtman L, Abikoff H, Klein RG et al (2004) Academic achievement and emotional status of children with ADHD treated with long-term methylphenidate and multimodal psychosocial treatment. J Am Acad Child Adolesc Psychiatry 43(7):812–819PubMedCrossRef

Kagan J (1965) The matching familiar figures test. Harvard University Press, Cambridge

Kellogg J, Hopko DR, Ashcraft MH (1999) The effect of time pressure on arithmetic performance. J Anxiety Disord 13(6):591–600PubMedCrossRef

Lahey BB, Pelham WE, Schaughency EA et al (1988) Dimensions and types of attention deficit disorder. J Am Acad Child Adolesc Psychiatry 27(3):330–335PubMedCrossRef

Levine MD (1992) The ANSER system. Pediatrics 89(1):170–171PubMed

Livingstone RL, Dykman J, Ackerman PT (1992) Psychiatric comorbidity and response to two doses of methylphenidate in children with attention deficit disorder. J Child Adolesc Psychol 2(2):115–122

March JS, Swanson JM, Arnold LE, Hoza B et al (2000) Anxiety as a predictor and outcome variable in the multimodal treatment study of children with ADHD (MTA). J Abnorm Child Psychol 28(6):527–541PubMedCrossRef

Milberger S, Biederman J, Faraone SV et al (1995) Attention deficit hyperactivity disorder and comorbid disorders: issues of overlapping symptoms. Am J Psychiatry 152(12):1793–1799PubMed

Or D, Cohen A, Tirosh E (2010) The reliability and validity of the aggregate neurobehavioral student health and educational review parent’s questionnaire (ANSER-PQ). J Child Neurol 25(2):157–164PubMedCrossRef

Pliszka S (1989) Effect of anxiety on cognition, behavior and stimulant response in ADHD. J Am Acad Child Psychiatry 28(6):882–887CrossRef

Pliszka SR (1992) Comorbidity of attention-deficit hyperactivity disorder and overanxious disorder. J Am Acad Child Psychiatry 31(2):197–203CrossRef

Pliszka S (1998) Comorbidity of attention-deficit hyperactivity disorder with psychiatric disorder. An overview. J Clin Psychiatry 59(7):50–58PubMed

Power TJ, Costigan TE, Eiraldi RB et al (2004) Variations in anxiety and depression as a function of ADHD subtypes defined by DSM-IV: do subtype differences exist or not. J Abnorm Child Psychol 32(1):27–37PubMedCrossRef

Schmidt SL, Snyder TJ, Rouget AC et al (2000) Empirical analysis of the selective attention and associated behavior checklists of the aggregate neurobehavioral student health and educational review. J Dev Behav Pediatr 21(3):165–171PubMed

Spencer TJ (2006) ADHD and comorbidity in childhood. J Clin Psychiatry 67(8):27–31PubMed

Spencer T, Biederman J, Wilens T (1999) Attention-deficit/hyperactivity disorder and comorbidity. Pediatr Clin N Am 46(5):915–927CrossRef

Tannock R, Ichowicz A, Schachar R (1995) Differential effects of methylphenidate on working memory in ADHD children with and without comorbid anxiety. J Am Acad Child Adolesc Psychiatry 34(7):886–896PubMedCrossRef

Tirosh E, Elhasid R, Cohen-Bar Kamah S et al (1993) Predictive value of placebo methylphenidate. Pediatr Neurol 9(2):131–133PubMedCrossRef

Vila G, Nollet-Clemencon C, de Blic J et al (1999) Assessment of anxiety disorders in asthmatic children. Psychosomatics 40(5):404–413PubMedCrossRef

Volk HE, Neuman RJ, Todd RD (2005) A systematic evaluation of ADHD and comorbid psychopathology in a population-based twin sample. J Am Acad Child Adolesc Psychiatry 44(8):768–775PubMedCrossRef

Title: Anxiety and methylphenidate in attention deficit hyperactivity disorder: a double-blind placebo-drug trial
Authors: Keren Moshe
Avi Karni
Emanuel Tirosh
Publication date: 01-09-2012
Publisher: Springer Vienna
Published in: ADHD Attention Deficit and Hyperactivity Disorders / Issue 3/2012
Print ISSN: 1866-6116
Electronic ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-012-0078-2

2024 ASCO Annual Meeting

Springer Medicine

Anxiety and methylphenidate in attention deficit hyperactivity disorder: a double-blind placebo-drug trial

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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