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23-10-2020 | ORIGINAL ARTICLE

The diagnostic value of SPECT CZT quantitative myocardial blood flow in high-risk patients

Authors: Konstantin V. Zavadovsky, MD, Andrew V. Mochula, PhD, Alina N. Maltseva, MD, Alla A. Boshchenko, MD, Andrew E. Baev, PhD, Sergey L. Andreev, PhD, Evgeniy A. Nesterov, PhD, Riccardo Liga, MD, Alessia Gimelli, MD

Published in: Journal of Nuclear Cardiology | Issue 3/2022

Abstract

Background

The objective of this study was to evaluate the accuracy of global MBF and MFR quantitation performed by myocardial perfusion scintigraphy (MPS) for the detection of multivessel coronary artery disease (CAD).

Methods

52 CAD patients underwent CZT MPS, with the evaluation of MBF and MFR, followed by invasive coronary angiography (ICA). According to MPS and ICA results, all patients were divided into three groups: (1) non-obstructive CAD and normal MPS scan (control group) (n = 7), (2) one vessel disease (1VD) (n = 16), (3) multivessel disease (MVD) (n = 29).

Results

Global absolute MBF and MFR were significantly reduced in MVD patients as compared to those with 1VD [0.93 (IQR 0.76; 1.39) vs 1.94 (1.37; 2.21) mL·min⁻¹·g⁻¹, P = .00012] and [1.4 (IQR 1.02; 1.85) vs 2.3 (1.8; 2.67), P = . 0 004], respectively. The Syntax score correlated with global stress MBF (ρ = − 0.64; P < .0001) and MFR (ρ = − 0.53; P = .0003). ROC analysis showed higher sensitivity and specificity for stress MBF and MFR compared with semiquantitative MPS stress evaluation. Multivariate regression analysis showed that only stress MBF [OR (95% CI) 0.59 (0.42-0.82); P < .0003] was an independent predictor of MVD.

Conclusions

Quantitative myocardial blood flow values assessed with the use of CZT camera may identify high-risk patients, such as those with multivessel disease.

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Title: The diagnostic value of SPECT CZT quantitative myocardial blood flow in high-risk patients
Authors: Konstantin V. Zavadovsky, MD
Andrew V. Mochula, PhD
Alina N. Maltseva, MD
Alla A. Boshchenko, MD
Andrew E. Baev, PhD
Sergey L. Andreev, PhD
Evgeniy A. Nesterov, PhD
Riccardo Liga, MD
Alessia Gimelli, MD
Publication date: 23-10-2020
Publisher: Springer International Publishing
Published in: Journal of Nuclear Cardiology / Issue 3/2022
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-020-02395-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The diagnostic value of SPECT CZT quantitative myocardial blood flow in high-risk patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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