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01-02-2018 | ASNC/SNMMI POSITION STATEMENT

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Authors: Venkatesh L. Murthy, Timothy M. Bateman, Rob S. Beanlands, Daniel S. Berman, Salvador Borges-Neto, Panithaya Chareonthaitawee, Manuel D. Cerqueira, Robert A. deKemp, E. Gordon DePuey, Vasken Dilsizian, Sharmila Dorbala, Edward P. Ficaro, Ernest V. Garcia, Henry Gewirtz, Gary V. Heller, Howard C. Lewin, Saurabh Malhotra, April Mann, Terrence D. Ruddy, Thomas H. Schindler, Ronald G. Schwartz, Piotr J. Slomka, Prem Soman, Marcelo F. Di Carli, Andrew Einstein, Raymond Russell, James R. Corbett

Published in: Journal of Nuclear Cardiology | Issue 1/2018

Excerpt

Writing Group
Venkatesh L. Murthy (cochair)*
Timothy M. Bateman^†
Rob S. Beanlands^‡
Daniel S. Berman^§
Salvador Borges-Neto^∥
Panithaya Chareonthaitawee^¶
Manuel D. Cerqueira^#
Robert A. deKemp^‡
E. Gordon DePuey**
Vasken Dilsizian^††
Sharmila Dorbala^‡‡
Edward P. Ficaro^§§
Ernest V. Garcia^∥∥
Henry Gewirtz^¶¶
Gary V. Heller^##
Howard C. Lewin***
Saurabh Malhotra^†††
April Mann^‡‡‡
Terrence D. Ruddy^‡
Thomas H. Schindler^§§§
Ronald G. Schwartz^∥∥∥
Piotr J. Slomka^§
Prem Soman^¶¶¶
Marcelo F. Di Carli (cochair)^‡‡

*Frankel Cardiovascular Center, Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI; ^†Mid America Heart Institute, Kansas City, MO; ^‡National Cardiac PET Centre, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada; ^§Departments of Imaging and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA; ^∥Division of Nuclear Medicine, Department of Radiology, and Division of Cardiology, Department of Medicine, Duke University School of Medicine, Duke University Health System, Durham, NC; ^¶Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN; ^#Department of Nuclear Medicine, Cleveland Clinic, Cleveland, OH; **Division of Nuclear Medicine, Department of Radiology, Mt. Sinai St. Luke’s and Mt. Sinai West Hospitals, Icahn School of Medicine at Mt. Sinai, New York, NY; ^††Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD; ^‡‡Cardiovascular Imaging Program, Brigham and Women’s Hospital, Boston, MA; ^§§Division of Nuclear Medicine, University of Michigan, Ann Arbor, MI; ^∥∥Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA; ^¶¶Massachusetts General Hospital and Harvard Medical School, Boston, MA; ^##Gagnon Cardiovascular Institute, Morristown Medical Center, Morristown, NJ; ***Cardiac Imaging Associates, Los Angeles, CA; ^†††Division of Cardiovascular Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY; ^‡‡‡Hartford Hospital, Hartford, CT; ^§§§Division of Nuclear Medicine, Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD; ^∥∥∥Cardiology Division, Department of Medicine, and Nuclear Medicine Division, Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY; and ^¶¶¶Division of Cardiology, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA

Expert Content Reviewers
Andrew Einstein^###
Raymond Russell^****
James R. Corbett^††††
SNMMI Cardiovascular Council Board of Directors, and ASNC Board of Directors

^###Division of Cardiology, Department of Medicine, and Department of Radiology, Columbia University Medical Center and New York–Presbyterian Hospital, New York, NY; ****Warren Alpert Medical School, Brown University, Providence, RI; and ^††††Frankel Cardiovascular Center, Division of Cardiovascular Medicine, Department of Internal Medicine, and Division of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI

…

Bateman TM, Maddahi J, Gray RJ, et al. Diffuse slow washout of myocardial thallium-201: a new scintigraphic indicator of extensive coronary artery disease. J Am Coll Cardiol. 1984;4:55–64.PubMedCrossRef

Lima RSL, Watson DD, Goode AR, et al. Incremental value of combined perfusion and function over perfusion alone by gated SPECT myocardial perfusion imaging for detection of severe three-vessel coronary artery disease. J Am Coll Cardiol. 2003;42:64–70.PubMedCrossRef

Maddahi J, Garcia EV, Berman DS, Waxman A, Swan HJ, Forrester J. Improved noninvasive assessment of coronary artery disease by quantitative analysis of regional stress myocardial distribution and washout of thallium-201. Circulation. 1981;64:924–35.PubMedCrossRef

Berman DS, Kang X, Slomka PJ, et al. Underestimation of extent of ischemia by gated SPECT myocardial perfusion imaging in patients with left main coronary artery disease. J Nucl Cardiol. 2007;14:521–8.PubMedCrossRef

Watson DD, Glover DK. Overview of tracer kinetics and cellular mechanisms of uptake. In: Beller GA, Zaret BA, editors. Clinical nuclear cardiology. 4th ed. Philadelphia, PA: Mosby; 2010. p. 3–13.CrossRef

Shanoudy H, Raggi P, Beller GA, et al. Comparison of technetium-99 m tetrofosmin and thallium-201 single-photon emission computed tomographic imaging for detection of myocardial perfusion defects in patients with coronary artery disease. J Am Coll Cardiol. 1998;31:331–7.PubMedCrossRef

Soman P, Taillefer R, DePuey EG, Udelson JE, Lahiri A. Enhanced detection of reversible perfusion defects by Tc-99 m sestamibi compared to Tc-99 m tetrofosmin during vasodilator stress SPECT imaging in mild-to-moderate coronary artery disease. J Am Coll Cardiol. 2001;37:458–62.PubMedCrossRef

Moody JB, Lee BC, Corbett JR, Ficaro EP, Murthy VL. Precision and accuracy of clinical quantification of myocardial blood flow by dynamic PET: a technical perspective. J Nucl Cardiol. 2015;22:935–51.PubMedCrossRef

Murthy VL, Di Carli MF. Non-invasive quantification of coronary vascular dysfunction for diagnosis and management of coronary artery disease. J Nucl Cardiol. 2012;19:1060–72.PubMedCrossRef

10.

Gould KL, Johnson NP, Bateman TM, et al. Anatomic versus physiologic assessment of coronary artery disease: Role of coronary flow reserve, fractional flow reserve, and positron emission tomography imaging in revascularization decision-making. J Am Coll Cardiol. 2013;62:1639–53.PubMedCrossRef

11.

CardioGen-82 Rubidium Rb 82 Generator [package insert]. Monroe Township, NJ: Bracco Diagnostics; April 2013.

12.

RUBY-FILL (rubidium Rb 82 generator) [package insert]. Kirkland, Quebec, Canada: Jubilant DraxImage; November 2016.

13.

Yu M, Guaraldi MT, Mistry M, et al. BMS-747158-02: a novel PET myocardial perfusion imaging agent. J Nucl Cardiol. 2007;14:789–98.PubMedCrossRef

14.

Sherif HM, Nekolla SG, Saraste A, et al. Simplified quantification of myocardial flow reserve with flurpiridaz F 18: validation with microspheres in a pig model. J Nucl Med. 2011;52:617–24.PubMedCrossRef

15.

Renaud JM, Yip K, Guimond J, et al. Characterization of 3-dimensional PET systems for accurate quantification of myocardial blood flow. J Nucl Med. 2017;58:103–9.PubMedCrossRef

16.

Keiding S, Sørensen M, Munk OL, Bender D. Human ¹³N-ammonia PET studies: The importance of measuring ¹³N-ammonia metabolites in blood. Metab Brain Dis. 2010;25:49–56.PubMedPubMedCentralCrossRef

17.

Yoshida K, Mullani N, Gould KL. Coronary flow and flow reserve by PET simplified for clinical applications using rubidium-82 or nitrogen-13-ammonia. J Nucl Med. 1996;37:1701–12.PubMed

18.

Erthal L, Erthal F, Beanlands RSB, Ruddy TD, deKemp RA, Dwivedi G. False-positive stress PET-CT imaging in a patient with interstitial injection. J Nucl Cardiol. 2016. doi:https://doi.org/10.1007/s12350-016-0634-9.

19.

Morris ED, Endres CJ, Schmidt KC, Christian BT, Muzic RF Jr, Fisher RE. Kinetic modeling in positron emission tomography. In: Wernick MN, Aarsvold JN, editors. Emission tomography. San Diego, CA: Academic Press; 2004. p. 499–540.CrossRef

20.

deKemp RA, Yoshinaga K, Beanlands RSB. Will 3-dimensional PET-CT enable the routine quantification of myocardial blood flow? J Nucl Cardiol. 2007;14:380–97.PubMedCrossRef

21.

Nagamachi S, Czernin J, Kim AS, et al. Reproducibility of measurements of regional resting and hyperemic myocardial blood flow assessed with PET. J Nucl Med. 1996;37:1626–31.PubMed

22.

Lortie M, Beanlands RSB, Yoshinaga K, Klein R, Dasilva JN, DeKemp RA. Quantification of myocardial blood flow with ⁸²Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging. 2007;34:1765–74.PubMedCrossRef

23.

Johnson NP, Gould KL. Physiological basis for angina and ST-segment change: PET-verified thresholds of quantitative stress myocardial perfusion and coronary flow reserve. JACC Cardiovasc Imaging. 2011;4:990–8.PubMedCrossRef

24.

Hunter CRRN, Klein R, Beanlands RS, deKemp RA. Patient motion effects on the quantification of regional myocardial blood flow with dynamic PET imaging. Med Phys. 2016;43:1829.PubMedCrossRef

25.

Raylman RR, Caraher JM, Hutchins GD. Sampling requirements for dynamic cardiac PET studies using image-derived input functions. J Nucl Med. 1993;34:440–7.PubMed

26.

Klein R, Ocneanu A, Renaud JM, Ziadi MC, Beanlands RSB, deKemp RA. Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification with ⁸²Rb dynamic PET imaging. J Nucl Cardiol. 2016. doi:https://doi.org/10.1007/s12350-016-0698-6.

27.

Slomka PJ, Alexanderson E, Jácome R, et al. Comparison of clinical tools for measurements of regional stress and rest myocardial blood flow assessed with ¹³N-ammonia PET/CT. J Nucl Med. 2012;53:171–81.PubMedCrossRef

28.

Dekemp RA, Declerck J, Klein R, et al. Multisoftware reproducibility study of stress and rest myocardial blood flow assessed with 3D dynamic PET/CT and a 1-tissue-compartment model of ⁸²Rb kinetics. J Nucl Med. 2013;54:571–7.PubMedCrossRef

29.

Nesterov SV, Deshayes E, Sciagrà R, et al. Quantification of myocardial blood flow in absolute terms using ⁸²Rb PET imaging: the RUBY-10 study. JACC Cardiovasc Imaging. 2014;11:1119–27.CrossRef

30.

Tahari AK, Lee A, Rajaram M, et al. Absolute myocardial flow quantification with ⁸²Rb PET/CT: comparison of different software packages and methods. Eur J Nucl Med Mol Imaging. 2014;41:126–35.PubMedCrossRef

31.

Henzlova MJ, Duvall WL, Einstein AJ, Travin MI, Verberne HJ. ASNC imaging guidelines for SPECT nuclear cardiology procedures: stress, protocols, and tracers. J Nucl Cardiol. 2016;23:606–39.PubMedCrossRef

32.

Böttcher M, Czernin J, Sun KT, Phelps ME, Schelbert HR. Effect of caffeine on myocardial blood flow at rest and during pharmacological vasodilation. J Nucl Med. 1995;36:2016–21.PubMed

33.

Kubo S, Tadamura E, Toyoda H, et al. Effect of caffeine intake on myocardial hyperemic flow induced by adenosine triphosphate and dipyridamole. J Nucl Med. 2004;45:730–8.PubMed

34.

Lapeyre AC, Goraya TY, Johnston DL, Gibbons RJ. The impact of caffeine on vasodilator stress perfusion studies. J Nucl Cardiol. 2004;11:506–11.PubMedCrossRef

35.

Kajander S, Joutsiniemi E, Saraste M, et al. Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease. Circulation. 2010;122:603–13.PubMedCrossRef

36.

Al-Mallah MH, Sitek A, Moore SC, Di Carli M, Dorbala S. Assessment of myocardial perfusion and function with PET and PET/CT. J Nucl Cardiol. 2010;17:498–513.PubMedPubMedCentralCrossRef

37.

Hsiao E, Ali B, Blankstein R, et al. Detection of obstructive coronary artery disease using regadenoson stress and ⁸²Rb PET/CT myocardial perfusion imaging. J Nucl Med. 2013;54:1748–54.PubMedPubMedCentralCrossRef

38.

Czernin J, Auerbach M, Sun KT, Phelps M, Schelbert HR. Effects of modified pharmacologic stress approaches on hyperemic myocardial blood flow. J Nucl Med. 1995;36:575–80.PubMed

39.

Bartunek J, Wijns W, Heyndrickx GR, de Bruyne B. Effects of dobutamine on coronary stenosis physiology and morphology: comparison with intracoronary adenosine. Circulation. 1999;100:243–9.PubMedCrossRef

40.

Petropoulakis PN, Pavlides GS, Manginas AN, Vassilikos VS, Cokkinos DV. Intracoronary flow velocity measurements in adjacent stenotic and normal coronary arteries during incremental intravenous dobutamine stress and intracoronary adenosine injection. Catheter Cardiovasc Interv. 1999;48:1–9.PubMedCrossRef

41.

Tadamura E, Iida H, Matsumoto K, et al. Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men. J Am Coll Cardiol. 2001;37:130–6.PubMedCrossRef

42.

Fung AY, Gallagher KP, Buda AJ. The physiologic basis of dobutamine as compared with dipyridamole stress interventions in the assessment of critical coronary stenosis. Circulation. 1987;76:943–51.PubMedCrossRef

43.

Li D, Dhawale P, Rubin PJ, Haacke EM, Gropler RJ. Myocardial signal response to dipyridamole and dobutamine: demonstration of the BOLD effect using a double-echo gradient-echo sequence. Magn Reson Med. 1996;36:16–20.PubMedCrossRef

44.

Skopicki HA, Abraham SA, Picard MH, Alpert NM, Fischman AJ, Gewirtz H. Effects of dobutamine at maximally tolerated dose on myocardial blood flow in humans with ischemic heart disease. Circulation. 1997;96:3346–52.PubMedCrossRef

45.

Danad I, Uusitalo V, Kero T, et al. Quantitative assessment of myocardial perfusion in the detection of significant coronary artery disease: cutoff values and diagnostic accuracy of quantitative [¹⁵O]H₂O PET imaging. J Am Coll Cardiol. 2014;64:1464–75.PubMedCrossRef

46.

Farhad H, Dunet V, Bachelard K, Allenbach G, Kaufmann PA, Prior JO. Added prognostic value of myocardial blood flow quantitation in rubidium-82 positron emission tomography imaging. Eur Heart J Cardiovasc Imaging. 2013;14:1203–10.PubMedCrossRef

47.

Hajjiri MM, Leavitt MB, Zheng H, Spooner AE, Fischman AJ, Gewirtz H. Comparison of positron emission tomography measurement of adenosine-stimulated absolute myocardial blood flow versus relative myocardial tracer content for physiological assessment of coronary artery stenosis severity and location. JACC Cardiovasc Imaging. 2009;2:751–8.PubMedCrossRef

48.

Fiechter M, Ghadri JR, Gebhard C, et al. Diagnostic value of ¹³N-ammonia myocardial perfusion PET: Added value of myocardial flow reserve. J Nucl Med. 2012;53:1230–4.PubMedCrossRef

49.

Herzog BA, Husmann L, Valenta I, et al. Long-term prognostic value of ¹³N-ammonia myocardial perfusion positron emission tomography added value of coronary flow reserve. J Am Coll Cardiol. 2009;54:150–6.PubMedCrossRef

50.

Murthy VL, Naya M, Foster CR, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. Circulation. 2011;124:2215–24.PubMedPubMedCentralCrossRef

51.

Parkash R, deKemp RA, Ruddy TD, et al. Potential utility of rubidium 82 PET quantification in patients with 3-vessel coronary artery disease. J Nucl Cardiol. 2004;11:440–9.PubMedCrossRef

52.

Ziadi MC, Dekemp RA, Williams K, et al. Does quantification of myocardial flow reserve using rubidium-82 positron emission tomography facilitate detection of multivessel coronary artery disease? J Nucl Cardiol. 2012;19:670–80.PubMedCrossRef

53.

Ziadi MC, Dekemp RA, Williams KA, et al. Impaired myocardial flow reserve on rubidium-82 positron emission tomography imaging predicts adverse outcomes in patients assessed for myocardial ischemia. J Am Coll Cardiol. 2011;58:740–8.PubMedCrossRef

54.

Murthy VL, Lee BC, Sitek A, et al. Comparison and prognostic validation of multiple methods of quantification of myocardial blood flow with ⁸²Rb PET. J Nucl Med. 2014;55:1952–8.PubMedCrossRef

55.

Bhave NM, Freed BH, Yodwut C, et al. Considerations when measuring myocardial perfusion reserve by cardiovascular magnetic resonance using regadenoson. J Cardiovasc Magn Reson. 2012;14:89.PubMedPubMedCentralCrossRef

56.

Gould KL, Pan T, Loghin C, Johnson NP, Guha A, Sdringola S. Frequent diagnostic errors in cardiac PET/CT due to misregistration of CT attenuation and emission PET images: A definitive analysis of causes, consequences, and corrections. J Nucl Med. 2007;48:1112–21.PubMedCrossRef

57.

Rajaram M, Tahari AK, Lee AH, et al. Cardiac PET/CT misregistration causes significant changes in estimated myocardial blood flow. J Nucl Med. 2013;54:50–4.PubMedCrossRef

58.

Chen GP, Branch KR, Alessio AM, et al. Effect of reconstruction algorithms on myocardial blood flow measurement with ¹³N-ammonia PET. J Nucl Med. 2007;48:1259–65.PubMedPubMedCentralCrossRef

59.

Peelukhana SV, Kerr H, Kolli KK, et al. Benefit of cardiac N-13 PET CFR for combined anatomical and functional diagnosis of ischemic coronary artery disease: a pilot study. Ann Nucl Med. 2014;28:746–60.PubMedCrossRef

60.

Kaufmann PA, Namdar M, Matthew F, et al. Novel Doppler assessment of intracoronary volumetric flow reserve: validation against PET in patients with or without flow-dependent vasodilation. J Nucl Med. 2005;46:1272–7.PubMed

61.

Merlet P, Mazoyer B, Hittinger L, et al. Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique. J Nucl Med. 1993;34:1899–904.PubMed

62.

Miller DD, Donohue TJ, Wolford TL, et al. Assessment of blood flow distal to coronary artery stenoses: correlations between myocardial positron emission tomography and poststenotic intracoronary Doppler flow reserve. Circulation. 1996;94:2447–54.PubMedCrossRef

63.

Shelton ME, Senneff MJ, Ludbrook PA, Sobel BE, Bergmann SR. Concordance of nutritive myocardial perfusion reserve and flow velocity reserve in conductance vessels in patients with chest pain with angiographically normal coronary arteries. J Nucl Med. 1993;34:717–22.PubMed

64.

Stewart RE, Miller DD, Bowers TR, et al. PET perfusion and vasodilator function after angioplasty for acute myocardial infarction. J Nucl Med. 1997;38:770–7.PubMed

65.

Bergmann SR, Herrero P, Markham J, Weinheimer CJ, Walsh MN. Noninvasive quantitation of myocardial blood flow in human subjects with oxygen-15-labeled water and positron emission tomography. J Am Coll Cardiol. 1989;14:639–52.PubMedCrossRef

66.

Chareonthaitawee P, Kaufmann PA, Rimoldi O, Camici PG. Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans. Cardiovasc Res. 2001;50:151–61.PubMedCrossRef

67.

Czernin J, Müller P, Chan S, et al. Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation. 1993;88:62–9.PubMedCrossRef

68.

Prior JO, Schindler TH, Facta AD, et al. Determinants of myocardial blood flow response to cold pressor testing and pharmacologic vasodilation in healthy humans. Eur J Nucl Med Mol Imaging. 2007;34:20–7.PubMedCrossRef

69.

Quercioli A, Montecucco F, Pataky Z, et al. Improvement in coronary circulatory function in morbidly obese individuals after gastric bypass-induced weight loss: relation to alterations in endocannabinoids and adipocytokines. Eur Heart J. 2013;34:2063–73.PubMedCrossRef

70.

Quercioli A, Pataky Z, Vincenti G, et al. Elevated endocannabinoid plasma levels are associated with coronary circulatory dysfunction in obesity. Eur Heart J. 2011;32:1369–78.PubMedCrossRef

71.

Tawakol A, Forgione MA, Stuehlinger M, et al. Homocysteine impairs coronary microvascular dilator function in humans. J Am Coll Cardiol. 2002;40:1051–8.PubMedCrossRef

72.

Bengel FM. Leaving relativity behind: quantitative clinical perfusion imaging. J Am Coll Cardiol. 2011;58:749–51.PubMedCrossRef

73.

Sawada S, Muzik O, Beanlands RS, Wolfe E, Hutchins GD, Schwaiger M. Interobserver and interstudy variability of myocardial blood flow and flow-reserve measurements with nitrogen 13 ammonia-labeled positron emission tomography. J Nucl Cardiol. 1995;2:413–22.PubMedCrossRef

74.

Schindler TH, Schelbert HR, Quercioli A, Dilsizian V. Cardiac PET imaging for the detection and monitoring of coronary artery disease and microvascular health. JACC Cardiovasc Imaging. 2010;3:623–40.PubMedCrossRef

75.

Tawakol A, Sims K, MacRae C, et al. Myocardial flow regulation in people with mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes/myoclonic epilepsy and ragged red fibers and other mitochondrial syndromes. Coron Artery Dis. 2003;14:197–205.PubMed

76.

Krivokapich J, Czernin J, Schelbert HR. Dobutamine positron emission tomography: absolute quantitation of rest and dobutamine myocardial blood flow and correlation with cardiac work and percent diameter stenosis in patients with and without coronary artery disease. J Am Coll Cardiol. 1996;28:565–72.PubMedCrossRef

77.

Krivokapich J, Smith GT, Huang SC, et al. ¹³N ammonia myocardial imaging at rest and with exercise in normal volunteers: quantification of absolute myocardial perfusion with dynamic positron emission tomography. Circulation. 1989;80:1328–37.PubMedCrossRef

78.

Schindler TH, Nitzsche EU, Olschewski M, et al. PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography. J Nucl Med. 2004;45:419–28.PubMed

79.

Mosher P, Ross J, McFate PA, Shaw RF. Control of coronary blood flow by an autoregulatory mechanism. Circ Res. 1964;14:250–9.PubMedCrossRef

80.

Schindler TH, Zhang X, Vincenti G, et al. Diagnostic value of PET-measured heterogeneity in myocardial blood flows during cold pressor testing for the identification of coronary vasomotor dysfunction. J Nucl Cardiol. 2007;14:688–97.PubMedPubMedCentralCrossRef

81.

Uren NG, Camici PG, Melin JA, et al. Effect of aging on myocardial perfusion reserve. J Nucl Med. 1995;36:2032–6.PubMed

82.

Duvernoy CS, Rattenhuber J, Seifert-Klauss V, Bengel F, Meyer C, Schwaiger M. Myocardial blood flow and flow reserve in response to short-term cyclical hormone replacement therapy in postmenopausal women. J Gend Specif Med. 2001;4(21–27):47.

83.

Duvernoy CS, Meyer C, Seifert-Klauss V, et al. Gender differences in myocardial blood flow dynamics: lipid profile and hemodynamic effects. J Am Coll Cardiol. 1999;33:463–70.PubMedCrossRef

84.

Motivala AA, Rose PA, Kim HM, et al. Cardiovascular risk, obesity, and myocardial blood flow in postmenopausal women. J Nucl Cardiol. 2008;15:510–7.PubMedCrossRef

85.

Uren NG, Melin JA, De Bruyne B, Wijns W, Baudhuin T, Camici PG. Relation between myocardial blood flow and the severity of coronary-artery stenosis. N Engl J Med. 1994;330:1782–8.PubMedCrossRef

86.

Beanlands RSB, Muzik O, Melon P, et al. Noninvasive quantification of regional myocardial flow reserve in patients with coronary atherosclerosis using nitrogen-13 ammonia positron emission tomography: determination of extent of altered vascular reactivity. J Am Coll Cardiol. 1995;26:1465–75.PubMedCrossRef

87.

Di Carli M, Czernin J, Hoh CK, et al. Relation among stenosis severity, myocardial blood flow, and flow reserve in patients with coronary artery disease. Circulation. 1995;91:1944–51.PubMedCrossRef

88.

Muzik O, Duvernoy C, Beanlands RSB, et al. Assessment of diagnostic performance of quantitative flow measurements in normal subjects and patients with angiographically documented coronary artery disease by means of nitrogen-13 ammonia and positron emission tomography. J Am Coll Cardiol. 1998;31:534–40.PubMedCrossRef

89.

Anagnostopoulos C, Almonacid A, Fakhri G, et al. Quantitative relationship between coronary vasodilator reserve assessed by ⁸²Rb PET imaging and coronary artery stenosis severity. Eur J Nucl Med Mol Imaging. 2008;35:1593–601.PubMedPubMedCentralCrossRef

90.

Yoshinaga K, Katoh C, Manabe O, et al. Incremental diagnostic value of regional myocardial blood flow quantification over relative perfusion imaging with generator-produced rubidium-82 PET. Circ J. 2011;75:2628–34.PubMedCrossRef

91.

Naya M, Murthy VL, Taqueti VR, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med. 2014;55:248–55.PubMedPubMedCentralCrossRef

92.

Fukushima K, Javadi MS, Higuchi T, et al. Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical ⁸²Rb PET perfusion imaging. J Nucl Med. 2011;52:726–32.PubMedCrossRef

93.

Slart RHJA, Zeebregts CJ, Hillege HL, et al. Myocardial perfusion reserve after a PET-driven revascularization procedure: a strong prognostic factor. J Nucl Med. 2011;52:873–9.PubMedCrossRef

94.

Tio RA, Dabeshlim A, Siebelink H-MJ, et al. Comparison between the prognostic value of left ventricular function and myocardial perfusion reserve in patients with ischemic heart disease. J Nucl Med. 2009;50:214–9.PubMedCrossRef

95.

Di Carli MF, Murthy VL. Cardiac PET/CT for the evaluation of known or suspected coronary artery disease. Radiographics. 2011;31:1239–54.PubMedPubMedCentralCrossRef

96.

Hachamovitch R, Rozanski A, Shaw LJ, et al. Impact of ischaemia and scar on the therapeutic benefit derived from myocardial revascularization vs. medical therapy among patients undergoing stress-rest myocardial perfusion scintigraphy. Eur Heart J. 2011;32:1012–24.PubMedCrossRef

97.

Gould KL, Johnson NP, Kaul S, et al. Patient selection for elective revascularization to reduce myocardial infarction and mortality: New lessons from randomized trials, coronary physiology, and statistics. Circ Cardiovasc Imaging. 2015;8:e003099.PubMedCrossRef

98.

Taqueti VR, Hachamovitch R, Murthy VL, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. Circulation. 2015;131:19–27.PubMedCrossRef

99.

Grundy SM, Benjamin IJ, Burke GL, et al. Diabetes and cardiovascular disease: A statement for healthcare professionals from the American Heart Association. Circulation. 1999;100:1134–46.PubMedCrossRef

100.

Rajagopalan N, Miller TD, Hodge DO, Frye RL, Gibbons RJ. Identifying high-risk asymptomatic diabetic patients who are candidates for screening stress single-photon emission computed tomography imaging. J Am Coll Cardiol. 2005;45:43–9.PubMedCrossRef

101.

Shaw LJ, Iskandrian A. Prognostic value of gated myocardial perfusion SPECT. J Nucl Cardiol. 2004;11:171–85.PubMedCrossRef

102.

Murthy VL, Naya M, Foster CR, et al. Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. Circulation. 2012;126:1858–68.PubMedPubMedCentralCrossRef

103.

U.S. Renal Data System. USRDS 2010 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2010.

104.

Charytan DM, Wallentin L, Lagerqvist B, et al. Early angiography in patients with chronic kidney disease: A collaborative systematic review. Clin J Am Soc Nephrol. 2009;4:1032–43.PubMedPubMedCentralCrossRef

105.

Gruberg L, Mintz GS, Mehran R, et al. The prognostic implications of further renal function deterioration within 48 h of interventional coronary procedures in patients with pre-existent chronic renal insufficiency. J Am Coll Cardiol. 2000;36:1542–8.PubMedCrossRef

106.

Cooper WA, O’Brien SM, Thourani VH, et al. Impact of renal dysfunction on outcomes of coronary artery bypass surgery. Circulation. 2006;113:1063–70.PubMedCrossRef

107.

Shin D-H, Choi D-J, Youn T-J, et al. Comparison of contrast-induced nephrotoxicity of iodixanol and iopromide in patients with renal insufficiency undergoing coronary angiography. Am J Cardiol. 2011;108:189–94.PubMedCrossRef

108.

Al-Mallah MH, Hachamovitch R, Dorbala S, Di Carli MF. Incremental prognostic value of myocardial perfusion imaging in patients referred to stress single-photon emission computed tomography with renal dysfunction. Circ Cardiovasc Imaging. 2009;2:429–36.PubMedCrossRef

109.

Murthy VL, Naya M, Foster CR, et al. Coronary vascular dysfunction and prognosis in patients with chronic kidney disease. JACC Cardiovasc Imaging. 2012;5:1025–34.PubMedPubMedCentralCrossRef

110.

Shah NR, Charytan DM, Murthy VL, et al. Prognostic value of coronary flow reserve in patients with dialysis-dependent ESRD. J Am Soc Nephrol. 2016;27:1823–9.PubMedCrossRef

111.

Majmudar MD, Murthy VL, Shah RV, et al. Quantification of coronary flow reserve in patients with ischaemic and non-ischaemic cardiomyopathy and its association with clinical outcomes. Eur Heart J Cardiovasc Imaging. 2015;16:900–9.PubMedPubMedCentralCrossRef

112.

Bratis K, Child N, Terrovitis J, et al. Coronary microvascular dysfunction in overt diabetic cardiomyopathy. IJC Metab Endocr. 2014;5:19–23.CrossRef

113.

Cecchi F, Olivotto I, Gistri R, Lorenzoni R, Chiriatti G, Camici PG. Coronary microvascular dysfunction and prognosis in hypertrophic cardiomyopathy. N Engl J Med. 2003;349:1027–35.PubMedCrossRef

114.

Dorbala S, Vangala D, Bruyere J, et al. Coronary microvascular dysfunction is related to abnormalities in myocardial structure and function in cardiac amyloidosis. JACC Heart Fail. 2014;2:358–67.PubMedPubMedCentralCrossRef

115.

Kalliokoski RJ, Kalliokoski KK, Sundell J, et al. Impaired myocardial perfusion reserve but preserved peripheral endothelial function in patients with Fabry disease. J Inherit Metab Dis. 2005;28:563–73.PubMedCrossRef

116.

Neglia D, Michelassi C, Trivieri MG, et al. Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction. Circulation. 2002;105:186–93.PubMedCrossRef

117.

Kofoed KF, Czernin J, Johnson J, et al. Effects of cardiac allograft vasculopathy on myocardial blood flow, vasodilatory capacity, and coronary vasomotion. Circulation. 1997;95:600–6.PubMedCrossRef

118.

Treasure CB, Vita J, Ganz P, et al. Loss of the coronary microvascular response to acetylcholine in cardiac transplant patients. Circulation. 1992;86:1156–64.PubMedCrossRef

119.

Spes CH, Klauss V, Mudra H, et al. Diagnostic and prognostic value of serial dobutamine stress echocardiography for noninvasive assessment of cardiac allograft vasculopathy: a comparison with coronary angiography and intravascular ultrasound. Circulation. 1999;100:509–15.PubMedCrossRef

120.

Spes CH, Mudra H, Schnaack SD, et al. Dobutamine stress echocardiography for noninvasive diagnosis of cardiac allograft vasculopathy: A comparison with angiography and intravascular ultrasound. Am J Cardiol. 1996;78:168–74.PubMedCrossRef

121.

Thompson D, Koster MJ, Wagner RH, Heroux A, Barron JT. Single photon emission computed tomography myocardial perfusion imaging to detect cardiac allograft vasculopathy. Eur Heart J Cardiovasc Imaging. 2012;13:271–5.PubMedCrossRef

122.

Manrique A, Bernard M, Hitzel A, et al. Diagnostic and prognostic value of myocardial perfusion gated SPECT in orthotopic heart transplant recipients. J Nucl Cardiol. 2010;17:197–206.PubMedCrossRef

123.

Hacker M, Hoyer HX, Uebleis C, et al. Quantitative assessment of cardiac allograft vasculopathy by real-time myocardial contrast echocardiography: a comparison with conventional echocardiographic analyses and [Tc99 m]-sestamibi SPECT. Eur J Echocardiogr. 2008;9:494–500.PubMed

124.

Kübrich M, Petrakopoulou P, Kofler S, et al. Impact of coronary endothelial dysfunction on adverse long-term outcome after heart transplantation. Transplantation. 2008;85:1580–7.PubMedCrossRef

125.

Wu Y-W, Chen Y-H, Wang S-S, et al. PET assessment of myocardial perfusion reserve inversely correlates with intravascular ultrasound findings in angiographically normal cardiac transplant recipients. J Nucl Med. 2010;51:906–12.PubMedCrossRef

126.

Allen-Auerbach M, Schöder H, Johnson J, et al. Relationship between coronary function by positron emission tomography and temporal changes in morphology by intravascular ultrasound (IVUS) in transplant recipients. J Heart Lung Transplant. 1999;18:211–9.PubMedCrossRef

127.

Mc Ardle BA, Davies RA, Chen L, et al. Prognostic value of rubidium-82 positron emission tomography in patients after heart transplant. Circ Cardiovasc Imaging. 2014;7:930–7.PubMedCrossRef

128.

Jaeger BR, Bengel FM, Odaka K, et al. Changes in myocardial vasoreactivity after drastic reduction of plasma fibrinogen and cholesterol: a clinical study in long-term heart transplant survivors using positron emission tomography. J Heart Lung Transplant. 2005;24:2022–30.PubMedCrossRef

129.

Kushwaha SS, Narula J, Narula N, et al. Pattern of changes over time in myocardial blood flow and microvascular dilator capacity in patients with normally functioning cardiac allografts. Am J Cardiol. 1998;82:1377–81.PubMedCrossRef

130.

Preumont N, Berkenboom G, Vachiery J, et al. Early alterations of myocardial blood flow reserve in heart transplant recipients with angiographically normal coronary arteries. J Heart Lung Transplant. 2000;19:538–45.PubMedCrossRef

131.

Murthy V, Naya M, Hachamovitch R, et al. Coronary vascular dysfunction and prognosis in patients age 75 and older [abstract]. J Nucl Med. 2012;53(suppl 1):22.

132.

Mieres JH, Shaw LJ, Hendel RC, et al. American Society of Nuclear Cardiology consensus statement: Task Force on Women and Coronary Artery Disease—the role of myocardial perfusion imaging in the clinical evaluation of coronary artery disease in women [correction]. J Nucl Cardiol. 2003;10:95–101.PubMedCrossRef

133.

Taqueti VR, Dorbala S, Wolinsky D, et al. Myocardial perfusion imaging in women for the evaluation of stable ischemic heart disease: state-of-the-evidence and clinical recommendations. J Nucl Cardiol. 2017. doi:https://doi.org/10.1007/s12350-017-0926-8.

134.

Johnson BD, Shaw LJ, Buchthal SD, et al. Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: Results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE). Circulation. 2004;109:2993–9.PubMedCrossRef

135.

Pepine CJ, Anderson RD, Sharaf BL, et al. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia: Results from the National Heart, Lung and Blood Institute WISE (Women’s Ischemia Syndrome Evaluation) study. J Am Coll Cardiol. 2010;55:2825–32.PubMedPubMedCentralCrossRef

136.

Taqueti VR, Shaw LJ, Cook NR, et al. Excess cardiovascular risk in women relative to men referred for coronary angiography is associated with severely impaired coronary flow reserve, not obstructive disease. Circulation. 2017;135:566–77.PubMedCrossRef

137.

Murthy VL, Naya M, Taqueti VR, et al. Effects of sex on coronary microvascular dysfunction and cardiac outcomes. Circulation. 2014;129:2518–27.PubMedPubMedCentralCrossRef

138.

Naya M, Murthy VL, Foster CR, et al. Prognostic interplay of coronary artery calcification and underlying vascular dysfunction in patients with suspected coronary artery disease. J Am Coll Cardiol. 2013;61:2098–106.PubMedPubMedCentralCrossRef

139.

Gould KL, Lipscomb K, Hamilton GW. Physiologic basis for assessing critical coronary stenosis: Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserve. Am J Cardiol. 1974;33:87–94.PubMedCrossRef

140.

Gould KL, Lipscomb K. Effects of coronary stenoses on coronary flow reserve and resistance. Am J Cardiol. 1974;34:48–55.PubMedCrossRef

141.

Fiechter M, Gebhard C, Ghadri JR, et al. Myocardial perfusion imaging with ¹³N-ammonia PET is a strong predictor for outcome. Int J Cardiol. 2013;167:1023–6.PubMedCrossRef

142.

Morton G, Chiribiri A, Ishida M, et al. Quantification of absolute myocardial perfusion in patients with coronary artery disease: Comparison between cardiovascular magnetic resonance and positron emission tomography. J Am Coll Cardiol. 2012;60:1546–55.PubMedCrossRef

143.

Di Carli MF, Charytan D, McMahon GT, Ganz P, Dorbala S, Schelbert HR. Coronary circulatory function in patients with the metabolic syndrome. J Nucl Med. 2011;52:1369–77.PubMedCrossRef

144.

Di Carli MF, Janisse J, Ager J, Grunberger G. Role of chronic hyperglycemia in the pathogenesis of coronary microvascular dysfunction in diabetes. J Am Coll Cardiol. 2003;41:1387–93.PubMedCrossRef

145.

Di Carli MF, Bianco-Batlles D, Landa ME, et al. Effects of autonomic neuropathy on coronary blood flow in patients with diabetes mellitus. Circulation. 1999;100:813–9.PubMedCrossRef

146.

Kaufmann PA, Gnecchi-Ruscone T, Schäfers KP, Lüscher TF, Camici PG. Low density lipoprotein cholesterol and coronary microvascular dysfunction in hypercholesterolemia. J Am Coll Cardiol. 2000;36:103–9.PubMedCrossRef

147.

Pitkänen O-P, Nuutila P, Raitakari OT, et al. Coronary flow reserve is reduced in young men with IDDM. Diabetes. 1998;47:248–54.PubMedCrossRef

148.

Prior JO, Quiñones MJ, Hernandez-Pampaloni M, et al. Coronary circulatory dysfunction in insulin resistance, impaired glucose tolerance, and type 2 diabetes mellitus. Circulation. 2005;111:2291–8.PubMedCrossRef

149.

Quiñones MJ, Hernandez-Pampaloni M, Schelbert H, et al. Coronary vasomotor abnormalities in insulin-resistant individuals. Ann Intern Med. 2004;140:700–8.PubMedCrossRef

150.

Rana O, Byrne CD, Kerr D, et al. Acute hypoglycemia decreases myocardial blood flow reserve in patients with type 1 diabetes mellitus and in healthy humans. Circulation. 2011;124:1548–56.PubMedCrossRef

151.

von Scholten BJ, Hasbak P, Christensen TE, et al. Cardiac ⁸²Rb PET/CT for fast and non-invasive assessment of microvascular function and structure in asymptomatic patients with type 2 diabetes. Diabetologia. 2016;59:371–8.CrossRef

152.

Valenta I, Dilsizian V, Quercioli A, Schelbert H, Schindler T. The influence of insulin resistance, obesity, and diabetes mellitus on vascular tone and myocardial blood flow. Curr Cardiol Rep. 2012;14:217–25.PubMedCrossRef

153.

Yokoyama I, Ohtake T, Momomura S, et al. Hyperglycemia rather than insulin resistance is related to reduced coronary flow reserve in NIDDM. Diabetes. 1998;47:119–24.PubMedCrossRef

154.

Yokoyama I, Momomura S, Ohtake T, et al. Reduced myocardial flow reserve in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1997;30:1472–7.PubMedCrossRef

155.

Alexánderson E, Jácome R, Jiménez-Santos M, et al. Evaluation of the endothelial function in hypertensive patients with ¹³N-ammonia PET. J Nucl Cardiol. 2012;19:979–86.PubMedCrossRef

156.

Hamasaki S, Al Suwaidi J, Higano ST, Miyauchi K, Holmes DR Jr, Lerman A. Attenuated coronary flow reserve and vascular remodeling in patients with hypertension and left ventricular hypertrophy. J Am Coll Cardiol. 2000;35:1654–60.PubMedCrossRef

157.

Houghton JL, Frank MJ, Carr AA, von Dohlen TW, Prisant LM. Relations among impaired coronary flow reserve, left ventricular hypertrophy and thallium perfusion defects in hypertensive patients without obstructive coronary artery disease. J Am Coll Cardiol. 1990;15:43–51.PubMedCrossRef

158.

Laine H, Raitakari OT, Niinikoski H, et al. Early impairment of coronary flow reserve in young men with borderline hypertension. J Am Coll Cardiol. 1998;32:147–53.PubMedCrossRef

159.

Dayanikli F, Grambow D, Muzik O, Mosca L, Rubenfire M, Schwaiger M. Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography. Circulation. 1994;90:808–17.PubMedCrossRef

160.

Yokoyama I, Ohtake T, Momomura S, et al. Impaired myocardial vasodilation during hyperemic stress with dipyridamole in hypertriglyceridemia. J Am Coll Cardiol. 1998;31:1568–74.PubMedCrossRef

161.

Yokoyama I, Ohtake T, Momomura S, et al. Altered myocardial vasodilatation in patients with hypertriglyceridemia in anatomically normal coronary arteries. Arterioscler Thromb Vasc Biol. 1998;18:294–9.PubMedCrossRef

162.

Yokoyama I, Ohtake T, Momomura S, Nishikawa J, Sasaki Y, Omata M. Reduced coronary flow reserve in hypercholesterolemic patients without overt coronary stenosis. Circulation. 1996;94:3232–8.PubMedCrossRef

163.

Yokoyama I, Murakami T, Ohtake T, et al. Reduced coronary flow reserve in familial hypercholesterolemia. J Nucl Med. 1996;37:1937–42.PubMed

164.

Bozbas H, Pirat B, Demirtas S, et al. Evaluation of coronary microvascular function in patients with end-stage renal disease, and renal allograft recipients. Atherosclerosis. 2009;202:498–504.PubMedCrossRef

165.

Charytan DM, Shelbert HR, Di Carli MF. Coronary microvascular function in early chronic kidney disease. Circ Cardiovasc Imaging. 2010;3:663–71.PubMedCrossRef

166.

Goldstein RA, Kirkeeide RL, Demer LL, et al. Relation between geometric dimensions of coronary artery stenoses and myocardial perfusion reserve in man. J Clin Invest. 1987;79:1473–8.PubMedPubMedCentralCrossRef

167.

Kirkeeide RL, Gould KL, Parsel L. Assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VII. Validation of coronary flow reserve as a single integrated functional measure of stenosis severity reflecting all its geometric dimensions. J Am Coll Cardiol. 1986;7:103–13.PubMedCrossRef

168.

Gould KL, Nakagawa Y, Nakagawa K, et al. Frequency and clinical implications of fluid dynamically significant diffuse coronary artery disease manifest as graded, longitudinal, base-to-apex myocardial perfusion abnormalities by noninvasive positron emission tomography. Circulation. 2000;101:1931–9.PubMedCrossRef

169.

Arnett EN, Isner JM, Redwood DR, et al. Coronary artery narrowing in coronary heart disease: Comparison of cineangiographic and necropsy findings. Ann Intern Med. 1979;91:350–6.PubMedCrossRef

170.

Nicholls SJ, Tuzcu EM, Crowe T, et al. Relationship between cardiovascular risk factors and atherosclerotic disease burden measured by intravascular ultrasound. J Am Coll Cardiol. 2006;47:1967–75.PubMedCrossRef

171.

Johnson NP, Gould KL. Integrating noninvasive absolute flow, coronary flow reserve, and ischemic thresholds into a comprehensive map of physiological severity. JACC Cardiovasc Imaging. 2012;5:430–40.PubMedCrossRef

172.

Naya M, Murthy VL, Blankstein R, et al. Quantitative relationship between the extent and morphology of coronary atherosclerotic plaque and downstream myocardial perfusion. J Am Coll Cardiol. 2011;58:1807–16.PubMedPubMedCentralCrossRef

173.

Dey D, Diaz Zamudio M, Schuhbaeck A, et al. Relationship between quantitative adverse plaque features from coronary computed tomography angiography and downstream impaired myocardial flow reserve by ¹³N-ammonia positron emission tomography: a pilot study. Circ Cardiovasc Imaging. 2015;8:e003255.PubMedPubMedCentralCrossRef

174.

Danad I, Raijmakers PG, Appelman YE, et al. Hybrid imaging using quantitative H ₂ ¹⁵ O PET and CT-based coronary angiography for the detection of coronary artery disease. J Nucl Med. 2013;54:55–63.PubMedCrossRef

175.

Liga R, Marini C, Coceani M, et al. Structural abnormalities of the coronary arterial wall—in addition to luminal narrowing—affect myocardial blood flow reserve. J Nucl Med. 2011;52:1704–12.PubMedCrossRef

176.

Kim H-S, Cho S-G, Kim JH, Bom H-S. Indirect radionuclide coronary angiography to evaluate gradients of myocardial blood flow and flow reserve through coronary stenosis using N-13 ammonia PET/CT. Chonnam Med J. 2013;49:69–74.PubMedPubMedCentralCrossRef

177.

Bateman TM, Gould KL, Carli MFD. Proceedings of the Cardiac PET Summit, 12 May 2014, Baltimore, MD: 3: Quantification of myocardial blood flow. J Nucl Cardiol. 2015;22:571–8.PubMedCrossRef

178.

Juneau D, Erthal F, Ohira H, et al. Clinical PET myocardial perfusion imaging and flow quantification. Cardiol Clin. 2016;34:69–85.PubMedCrossRef

179.

Topol EJ, Nissen SE. Our preoccupation with coronary luminology: The dissociation between clinical and angiographic findings in ischemic heart disease. Circulation. 1995;92:2333–42.PubMedCrossRef

180.

Meijboom WB, Van Mieghem CAG, van Pelt N, et al. Comprehensive assessment of coronary artery stenoses: Computed tomography coronary angiography versus conventional coronary angiography and correlation with fractional flow reserve in patients with stable angina. J Am Coll Cardiol. 2008;52:636–43.PubMedCrossRef

181.

Toth G, Hamilos M, Pyxaras S, et al. Evolving concepts of angiogram: fractional flow reserve discordances in 4000 coronary stenoses. Eur Heart J. 2014;35:2831–8.PubMedCrossRef

182.

Min JK, Taylor CA, Achenbach S, et al. Noninvasive fractional flow reserve derived from coronary CT angiography: clinical data and scientific principles. JACC Cardiovasc Imaging. 2015;8:1209–22.PubMedCrossRef

183.

Pijls NH, Van Son JA, Kirkeeide RL, De Bruyne B, Gould KL. Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty. Circulation. 1993;87:1354–67.PubMedCrossRef

184.

Pijls NHJ, de Bruyne B, Peels K, et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med. 1996;334:1703–8.PubMedCrossRef

185.

De Bruyne B, Paulus WJ, Vantrimpont PJ, Sys SU, Heyndrickx GR, Pijls NHJ. Transstenotic coronary pressure gradient measurement in humans: In vitro and in vivo evaluation of a new pressure monitoring angioplasty guide wire. J Am Coll Cardiol. 1993;22:119–26.PubMedCrossRef

186.

De Bruyne B, Baudhuin T, Melin JA, et al. Coronary flow reserve calculated from pressure measurements in humans: Validation with positron emission tomography. Circulation. 1994;89:1013–22.PubMedCrossRef

187.

Tonino PA, De Bruyne B, Pijls N. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med. 2009;360:213–24.PubMedCrossRef

188.

De Bruyne B, Pijls NHJ, Kalesan B, et al. Fractional flow reserve–guided PCI versus medical therapy in stable coronary disease. N Engl J Med. 2012;367:991–1001.PubMedCrossRef

189.

Pijls NHJ, van Schaardenburgh P, Manoharan G, et al. Percutaneous coronary intervention of functionally nonsignificant stenosis: 5-year follow-up of the DEFER study. J Am Coll Cardiol. 2007;49:2105–11.PubMedCrossRef

190.

van de Hoef TP, Siebes M, Spaan JA, Piek JJ. Fundamentals in clinical coronary physiology: Why coronary flow is more important than coronary pressure. Eur Heart J. 2015;36:3312–9.PubMedCrossRef

191.

Blows LJ, Redwood SR. The pressure wire in practice. Heart. 2007;93:419–22.PubMedCrossRef

192.

Plein S, Motwani M. Fractional flow reserve as the reference standard for myocardial perfusion studies: fool’s gold? Eur Heart J Cardiovasc Imaging. 2013;14:1211–3.PubMedCrossRef

193.

van de Hoef TP, Bax M, Damman P, et al. Impaired coronary autoregulation is associated with long-term fatal events in patients with stable coronary artery disease. Circ Cardiovasc Interv. 2013;6:329–35.PubMedCrossRef

194.

van de Hoef TP, van Lavieren MA, Damman P, et al. Physiological basis and long-term clinical outcome of discordance between fractional flow reserve and coronary flow velocity reserve in coronary stenoses of intermediate severity. Circ Cardiovasc Interv. 2014;7:301–11.PubMedCrossRef

195.

De Bruyne B, Hersbach F, Pijls NHJ, et al. Abnormal epicardial coronary resistance in patients with diffuse atherosclerosis but “normal” coronary angiography. Circulation. 2001;104:2401–6.PubMedCrossRef

196.

Hwang D, Jeon K-H, Lee JM, et al. Diagnostic performance of resting and hyperemic invasive physiological indices to define myocardial ischemia: Validation with ¹³N-ammonia positron emission tomography. JACC Cardiovasc Interv. 2017;10:751–60.PubMedCrossRef

197.

Hennigan B, Oldroyd KG, Berry C, et al. Discordance between resting and hyperemic indices of coronary stenosis severity: The VERIFY 2 study (a comparative study of resting coronary pressure gradient, instantaneous wave-free ratio and fractional flow reserve in an unselected population referred for invasive angiography). Circ Cardiovasc Interv. 2016;9:e004016.PubMedCrossRef

198.

Johnson NP, Kirkeeide RL, Asrress KN, et al. Does the instantaneous wave-free ratio approximate the fractional flow reserve? J Am Coll Cardiol. 2013;61:1428–35.PubMedCrossRef

199.

Jeremias A, Maehara A, Généreux P, et al. Multicenter core laboratory comparison of the instantaneous wave-free ratio and resting Pd/Pa with fractional flow reserve: The RESOLVE study. J Am Coll Cardiol. 2014;63:1253–61.PubMedCrossRef

200.

Götberg M, Christiansen EH, Gudmundsdottir IJ, et al. Instantaneous wave-free ratio versus fractional flow reserve to guide PCI. N Engl J Med. 2017;376:1813–23.PubMedCrossRef

201.

Davies JE, Sen S, Dehbi H-M, et al. Use of the instantaneous wave-free ratio or fractional flow reserve in PCI. N Engl J Med. 2017;376:1824–34.PubMedCrossRef

202.

Dilsizian V, Bacharach SL, Beanlands RS, et al. ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures. J Nucl Cardiol. 2016;23:1187–226.PubMedCrossRef

203.

Barbato E, Aarnoudse W, Aengevaeren WR, et al. Validation of coronary flow reserve measurements by thermodilution in clinical practice. Eur Heart J. 2004;25:219–23.PubMedCrossRef

204.

Escaned J, Echavarría-Pinto M. Moving beyond coronary stenosis: Has the time arrived to address important physiological questions not answered by fractional flow reserve alone? Circ Cardiovasc Interv. 2014;7:282–4.PubMedCrossRef

205.

Wada T, Hirata K, Shiono Y, et al. Coronary flow velocity reserve in three major coronary arteries by transthoracic echocardiography for the functional assessment of coronary artery disease: A comparison with fractional flow reserve. Eur Heart J Cardiovasc Imaging. 2014;15:399–408.PubMedCrossRef

206.

Gaibazzi N, Rigo F, Lorenzoni V, et al. Comparative prediction of cardiac events by wall motion, wall motion plus coronary flow reserve, or myocardial perfusion analysis: A multicenter study of contrast stress echocardiography. JACC Cardiovasc Imaging. 2013;6:1–12.PubMedCrossRef

207.

Wu J, Barton D, Xie F, et al. Comparison of fractional flow reserve assessment with demand stress myocardial contrast echocardiography in angiographically intermediate coronary stenoses. Circ Cardiovasc Imaging. 2016;9:e004129.PubMedCrossRef

208.

Leung DY, Leung M. Non-invasive/invasive imaging: significance and assessment of coronary microvascular dysfunction. Heart. 2011;97:587–95.PubMedCrossRef

209.

Combined Pressure and Flow Measurements to Guide Treatment of Coronary Stenoses (DEFINE-FLOW). ClinicalTrials.gov website. https://clinicaltrials.gov/ct2/show/NCT02328820. Published December 18, 2014. Updated May 12, 2016. Accessed September 14, 2017.

210.

Johnson NP, Kirkeeide RL, Gould KL. Is discordance of coronary flow reserve and fractional flow reserve due to methodology or clinically relevant coronary pathophysiology? JACC Cardiovasc Imaging. 2012;5:193–202.PubMedCrossRef

211.

Johnson NP, Gould KL. Regadenoson versus dipyridamole hyperemia for cardiac PET imaging. JACC Cardiovasc Imaging. 2015;8:438–47.PubMedCrossRef

212.

Hutchins GD, Schwaiger M, Rosenspire KC, Krivokapich J, Schelbert H, Kuhl DE. Noninvasive quantification of regional blood flow in the human heart using N-13 ammonia and dynamic positron emission tomographic imaging. J Am Coll Cardiol. 1990;15:1032–42.PubMedCrossRef

213.

Chan SY, Brunken RC, Czernin J, et al. Comparison of maximal myocardial blood flow during adenosine infusion with that of intravenous dipyridamole in normal men. J Am Coll Cardiol. 1992;20:979–85.PubMedCrossRef

214.

Böttcher M, Czernin J, Sun K, Phelps ME, Schelbert HR. Effect of β1 adrenergic receptor blockade on myocardial blood flow and vasodilatory capacity. J Nucl Med. 1997;38:442–6.PubMed

215.

Campisi R, Czernin J, Karpman HL, Schelbert HR. Coronary vasodilatory capacity and flow reserve in normal myocardium supplied by bypass grafts late after surgery. Am J Cardiol. 1997;80:27–31.PubMedCrossRef

216.

Nitzsche EU, Choi Y, Czernin J, Hoh CK, Huang S-C, Schelbert HR. Noninvasive quantification of myocardial blood flow in humans: a direct comparison of the [¹³N]ammonia and the [¹⁵O]water techniques. Circulation. 1996;93:2000–6.PubMedCrossRef

217.

Muzik O, Paridon SM, Singh TP, Morrow WR, Dayanikli F, Di Carli MF. Quantification of myocardial blood flow and flow reserve in children with a history of Kawasaki disease and normal coronary arteries using positron emission tomography. J Am Coll Cardiol. 1996;28:757–62.PubMedCrossRef

218.

DeGrado TR, Hanson MW, Turkington TG, et al. Estimation of myocardial blood flow for longitudinal studies with ¹³N-labeled ammonia and positron emission tomography. J Nucl Cardiol. 1996;3:494–507.PubMedCrossRef

219.

Schindler TH, Cardenas J, Prior JO, et al. Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory function. J Am Coll Cardiol. 2006;47:1188–95.PubMedCrossRef

220.

Valenta I, Quercioli A, Vincenti G, et al. Structural epicardial disease and microvascular function are determinants of an abnormal longitudinal myocardial blood flow difference in cardiovascular risk individuals as determined with PET/CT. J Nucl Cardiol. 2010;17:1023–33.PubMedCrossRef

221.

Renaud JM, Dasilva JN, Beanlands RSB, Dekemp RA. Characterizing the normal range of myocardial blood flow with ⁸²rubidium and ¹³N-ammonia PET imaging. J Nucl Cardiol. 2013;20:578–91.PubMedCrossRef

222.

Lin JW, Sciacca RR, Chou RL, Laine AF, Bergmann SR. Quantification of myocardial perfusion in human subjects using ⁸²Rb and wavelet-based noise reduction. J Nucl Med. 2001;42:201–8.PubMed

223.

Manabe O, Yoshinaga K, Katoh C, Naya M, deKemp RA, Tamaki N. Repeatability of rest and hyperemic myocardial blood flow measurements with ⁸²Rb dynamic PET. J Nucl Med. 2009;50:68–71.PubMedCrossRef

224.

Prior JO, Allenbach G, Valenta I, et al. Quantification of myocardial blood flow with ⁸²Rb positron emission tomography: clinical validation with ¹⁵O-water. Eur J Nucl Med Mol Imaging. 2012;39:1037–47.PubMedPubMedCentralCrossRef

225.

Sdringola S, Johnson NP, Kirkeeide RL, Cid E, Gould KL. Impact of unexpected factors on quantitative myocardial perfusion and coronary flow reserve in young, asymptomatic volunteers. JACC Cardiovasc Imaging. 2011;4:402–12.PubMedCrossRef

226.

Germino M, Ropchan J, Mulnix T, et al. Quantification of myocardial blood flow with ⁸²Rb: Validation with ¹⁵O-water using time-of-flight and point-spread-function modeling. EJNMMI Res. 2016;6:68.PubMedPubMedCentralCrossRef

227.

Farhad H, Murthy VL. Pharmacologic manipulation of coronary vascular physiology for the evaluation of coronary artery disease. Pharmacol Ther. 2013;149:121–32.CrossRef

228.

Nienaber CA, Ratib O, Gambhir SS, et al. A quantitative index of regional blood flow in canine myocardium derived noninvasively with N-13 ammonia and dynamic positron emission tomography. J Am Coll Cardiol. 1991;17:260–9.PubMedCrossRef

229.

Schelbert HR, Phelps ME, Hoffman E, Huang S-C, Kuhl DE. Regional myocardial blood flow, metabolism and function assessed noninvasively with positron emission tomography. Am J Cardiol. 1980;46:1269–77.PubMedCrossRef

230.

De Bruyne B, Oldroyd KG, Pijls NHJ. Microvascular (dys)function and clinical outcome in stable coronary disease. J Am Coll Cardiol. 2016;67:1170–2.PubMedCrossRef

Title: Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC
Authors: Venkatesh L. Murthy
Timothy M. Bateman
Rob S. Beanlands
Daniel S. Berman
Salvador Borges-Neto
Panithaya Chareonthaitawee
Manuel D. Cerqueira
Robert A. deKemp
E. Gordon DePuey
Vasken Dilsizian
Sharmila Dorbala
Edward P. Ficaro
Ernest V. Garcia
Henry Gewirtz
Gary V. Heller
Howard C. Lewin
Saurabh Malhotra
April Mann
Terrence D. Ruddy
Thomas H. Schindler
Ronald G. Schwartz
Piotr J. Slomka
Prem Soman
Marcelo F. Di Carli
Andrew Einstein
Raymond Russell
James R. Corbett
Publication date: 01-02-2018
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 1/2018
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-017-1110-x

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A joint procedural position statement on imaging in cardiac sarcoidosis: from the Cardiovascular and Inflammation & Infection Committees of the European Association of Nuclear Medicine, the European Association of Cardiovascular Imaging, and the American Society of Nuclear Cardiology

The very hungry caterpillar and the ongoing effort to reduce radiation in myocardial perfusion scintigraphy: Have we become the beautiful butterfly?

SPECT but not PET remains as the working horse of the state of the art nuclear cardiac imaging laboratory: Con

Multimodality imaging: Bird’s eye view from The European Society of Cardiology Congress 2017, Barcelona, August 26-30, 2017