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01-04-2017 | Editorial

¹²³I-mIBG scintigraphy: Clinical tool for assessing renal sympathetic activity?

Authors: Christopher George, MD, Pradeep G. Bhambhvani, MD, Suzanne Oparil, MD

Published in: Journal of Nuclear Cardiology | Issue 2/2017

Excerpt

Among patients with treatment-resistant hypertension, transcatheter renal denervation has been shown to reduce blood pressure (BP) in a number of uncontrolled, unblinded clinical trials.1 However, in a prospective, single-blind, randomized trial that compared transcatheter renal denervation to a sham procedure, there was no significant difference in systolic BP between the two treatment arms at 6 months follow-up.2 Proposed reasons for the lack of benefit include a substantial placebo effect related to the procedure, differences in medication adherence such that the sham-treated control group may have taken more antihypertensive medications, operator inexperience with transcatheter renal denervation, and performance of an inadequate number of ablations in each renal artery.3 It has been postulated that operator inexperience and performance of too few ablations may have led to incomplete denervation and therefore an inadequate BP response to the procedure. The absence of a readily available methodology to define completeness of transcatheter renal denervation in humans remains as an unmet need in defining the potential role of the procedure in clinical practice. …

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Title: 123I-mIBG scintigraphy: Clinical tool for assessing renal sympathetic activity?
Authors: Christopher George, MD
Pradeep G. Bhambhvani, MD
Suzanne Oparil, MD
Publication date: 01-04-2017
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 2/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0764-0

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¹²³I-mIBG scintigraphy: Clinical tool for assessing renal sympathetic activity?

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