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01-12-2017 | Original Article

Respiratory gating in cardiac PET: Effects of adenosine and dipyridamole

Authors: Martin Lyngby Lassen, MSc, Thomas Rasmussen, MD, PhD, Thomas E. Christensen, MD, Andreas Kjær, MD, PhD, DMSc, Philip Hasbak, MD

Published in: Journal of Nuclear Cardiology | Issue 6/2017

Abstract

Background

Respiratory motion due to breathing during cardiac positron emission tomography (PET) results in spatial blurring and erroneous tracer quantification. Respiratory gating might represent a solution by dividing the PET coincidence dataset into smaller respiratory phase subsets. The aim of our study was to compare the resulting imaging quality by the use of a time-based respiratory gating system in two groups administered either adenosine or dipyridamole as the pharmacological stress agent.

Methods and Results

Forty-eight patients were randomized to adenosine or dipyridamole cardiac stress ⁸²RB-PET. Respiratory rates and depths were measured by a respiratory gating system in addition to registering actual respiratory rates. Patients undergoing adenosine stress showed a decrease in measured respiratory rate from initial to later scan phase measurements [12.4 (±5.7) vs 5.6 (±4.7) min⁻¹, P < .001] and tended to have a lower frequency of successful respiratory gating compared to dipyridamole (47% vs 71%, P = .12). As a result, imaging quality was superior in the dipyridamole group compared to adenosine.

Conclusions

If respiratory gating is considered for use in cardiac PET, a dipyridamole stress protocol is recommended as it, compared to adenosine, causes a more uniform respiration and results in a higher frequency of successful respiratory gating and thereby superior imaging quality.

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Title: Respiratory gating in cardiac PET: Effects of adenosine and dipyridamole
Authors: Martin Lyngby Lassen, MSc
Thomas Rasmussen, MD, PhD
Thomas E. Christensen, MD
Andreas Kjær, MD, PhD, DMSc
Philip Hasbak, MD
Publication date: 01-12-2017
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 6/2017
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-016-0631-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Respiratory gating in cardiac PET: Effects of adenosine and dipyridamole

Abstract

Background

Methods and Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods and Results

Conclusions

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