Skip to main content
Top
Published in: Journal of Nuclear Cardiology 5/2016

01-10-2016 | Editorial

Prognostic impact of TID in regadenoson MPI: Some patients and certain events

Authors: Adrián I. Löffler, MD, Jamieson M. Bourque, MD, MHS

Published in: Journal of Nuclear Cardiology | Issue 5/2016

Login to get access

Excerpt

Single-photon emission-computed tomographic (SPECT) myocardial perfusion imaging (MPI) has incremental diagnostic and prognostic value over exercise stress electrocardiography, and the assessment of transient ischemic dilation (TID) is a key contributor to its ability to detect higher risk patients. The diagnostic and prognostic role of TID has been evaluated extensively in those undergoing exercise MPI.1,2 However, approximately 50% of the ~10 million MPI studies performed annually in the US undergo pharmacologic MPI,3 the majority receiving regadenoson for vasodilator stress due to its improved tolerability by patients, safety profile, and ease of administration.4 Given the high prevalence of this testing, the significance of TID in this population is of high importance. The diagnostic role of TID in regadenoson MPI has been assessed previously, but the prognostic impact has not determined. …
Literature
1.
go back to reference Teddy Weiss A, Berman DS, Lew AS, Nielsen J, Potkin B, Swan HJC, et al. Transient ischemic dilation of the left ventricle on stress thallium-201 scintigraphy: A marker of severe and extensive coronary artery disease. J Am Coll Cardiol 1987;9:752-9.CrossRef Teddy Weiss A, Berman DS, Lew AS, Nielsen J, Potkin B, Swan HJC, et al. Transient ischemic dilation of the left ventricle on stress thallium-201 scintigraphy: A marker of severe and extensive coronary artery disease. J Am Coll Cardiol 1987;9:752-9.CrossRef
2.
go back to reference Mazzanti M, Germano G, Kiat H, Kavanagh PB, Alexanderson E, Friedman JD, et al. Identification of severe and extensive coronary artery disease by automatic measurement of transient ischemic dilation of the left ventricle in dual-isotope myocardial perfusion SPECT. J Am Coll Cardiol 1996;27:1612-20.CrossRefPubMed Mazzanti M, Germano G, Kiat H, Kavanagh PB, Alexanderson E, Friedman JD, et al. Identification of severe and extensive coronary artery disease by automatic measurement of transient ischemic dilation of the left ventricle in dual-isotope myocardial perfusion SPECT. J Am Coll Cardiol 1996;27:1612-20.CrossRefPubMed
3.
go back to reference Zoghbi GJ, Iskandrian AE. Selective adenosine agonists and myocardial perfusion imaging. J Nucl Cardiol 2012;19:126-41.CrossRefPubMed Zoghbi GJ, Iskandrian AE. Selective adenosine agonists and myocardial perfusion imaging. J Nucl Cardiol 2012;19:126-41.CrossRefPubMed
4.
go back to reference Hage FG, Ghimire G, Lester D, McKay J, Bleich S, El-Hajj S, et al. The prognostic value of regadenoson myocardial perfusion imaging. J Nucl Cardiol. 2015. doi:10.1007/s12350-014-0050-y. Hage FG, Ghimire G, Lester D, McKay J, Bleich S, El-Hajj S, et al. The prognostic value of regadenoson myocardial perfusion imaging. J Nucl Cardiol. 2015. doi:10.​1007/​s12350-014-0050-y.
5.
go back to reference McLaughlin MGDP. Transient ischemic dilation: A powerful diagnostic and prognostic finding of stress myocardial perfusion imaging. J Nucl Cardiol 2002;9:663-7.CrossRefPubMed McLaughlin MGDP. Transient ischemic dilation: A powerful diagnostic and prognostic finding of stress myocardial perfusion imaging. J Nucl Cardiol 2002;9:663-7.CrossRefPubMed
6.
go back to reference Marcassa C, Galli M, Baroffio C, Campini R, Giannuzzi P. Transient left ventricular dilation at quantitative stress-rest sestamibi tomography: Clinical, electrocardiographic, and angiographic correlates. J Nucl Cardiol 1999;6:397-405.CrossRefPubMed Marcassa C, Galli M, Baroffio C, Campini R, Giannuzzi P. Transient left ventricular dilation at quantitative stress-rest sestamibi tomography: Clinical, electrocardiographic, and angiographic correlates. J Nucl Cardiol 1999;6:397-405.CrossRefPubMed
7.
go back to reference Bestetti A, Di Leo C, Alessi A, Triulzi A, Tagliabue L, Tarolo GI. Post-stress end-systolic left ventricular dilation: A marker of endocardial post-ischemic stunning. Nucl Med Commun 2001;22:685-93.CrossRefPubMed Bestetti A, Di Leo C, Alessi A, Triulzi A, Tagliabue L, Tarolo GI. Post-stress end-systolic left ventricular dilation: A marker of endocardial post-ischemic stunning. Nucl Med Commun 2001;22:685-93.CrossRefPubMed
8.
go back to reference Dhalla AK, Wong M, Wang W, Biaggioni I, Belardinelli L. Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats. J Pharmacol Exp Ther 2006;316:695-702.CrossRefPubMed Dhalla AK, Wong M, Wang W, Biaggioni I, Belardinelli L. Tachycardia caused by A2A adenosine receptor agonists is mediated by direct sympathoexcitation in awake rats. J Pharmacol Exp Ther 2006;316:695-702.CrossRefPubMed
9.
go back to reference Hage FG, Heo J, Franks B, Belardinelli L, Blackburn B, Wang W, et al. Differences in heart rate response to adenosine and regadenoson in patients with and without diabetes mellitus. Am Heart J 2009;157:771-6.CrossRefPubMed Hage FG, Heo J, Franks B, Belardinelli L, Blackburn B, Wang W, et al. Differences in heart rate response to adenosine and regadenoson in patients with and without diabetes mellitus. Am Heart J 2009;157:771-6.CrossRefPubMed
10.
go back to reference Chouraqui P, Rodrigues EA, Berman DS, Maddahi J. Significance of dipyridamole-induced transient dilation of the left ventricle during thallium-201 scintigraphy in suspected coronary artery disease. Am J Cardiol 1990;66:689-94.CrossRefPubMed Chouraqui P, Rodrigues EA, Berman DS, Maddahi J. Significance of dipyridamole-induced transient dilation of the left ventricle during thallium-201 scintigraphy in suspected coronary artery disease. Am J Cardiol 1990;66:689-94.CrossRefPubMed
11.
go back to reference Hozumi T, Yoshida K, Akasaka T, Asami Y, Ogata Y, Takagi T, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by doppler echocardiography: Comparison with invasive technique. J Am Coll Cardiol 1998;32:1251-9.CrossRefPubMed Hozumi T, Yoshida K, Akasaka T, Asami Y, Ogata Y, Takagi T, et al. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by doppler echocardiography: Comparison with invasive technique. J Am Coll Cardiol 1998;32:1251-9.CrossRefPubMed
12.
go back to reference Xu Y, Arsanjani R, Morgan C, Hyun M, Lemley M, Fish M, et al. Transient ischemic dilation for coronary artery disease in quantitative analysis of same-day sestamibi myocardial perfusion SPECT. J Nucl Cardiol 2012;19:465-73.CrossRefPubMedPubMedCentral Xu Y, Arsanjani R, Morgan C, Hyun M, Lemley M, Fish M, et al. Transient ischemic dilation for coronary artery disease in quantitative analysis of same-day sestamibi myocardial perfusion SPECT. J Nucl Cardiol 2012;19:465-73.CrossRefPubMedPubMedCentral
13.
go back to reference Petretta M, Acampa W, Daniele S, Petretta MP, Nappi C, et al. Transient ischemic dilation in SPECT myocardial perfusion imaging for prediction of severe coronary artery disease in diabetic patients. J Nucl Cardiol. 2012;20:45-52.CrossRefPubMed Petretta M, Acampa W, Daniele S, Petretta MP, Nappi C, et al. Transient ischemic dilation in SPECT myocardial perfusion imaging for prediction of severe coronary artery disease in diabetic patients. J Nucl Cardiol. 2012;20:45-52.CrossRefPubMed
14.
go back to reference Jamieson M, Bourque MD. MHS. Contemporary relevance of TID: Based on the company it keeps. J Nucl Cardiol 2015;22:535-8. Jamieson M, Bourque MD. MHS. Contemporary relevance of TID: Based on the company it keeps. J Nucl Cardiol 2015;22:535-8.
15.
go back to reference Valdiviezo C, Motivala AA, Hachamovitch R, Chamarthy HM, Navarro PC, et al. The significance of transient ischemic dilation in the setting of otherwise normal SPECT radionuclide myocardial perfusion images. J Nucl Cardiol 2011;18:220-9.CrossRefPubMed Valdiviezo C, Motivala AA, Hachamovitch R, Chamarthy HM, Navarro PC, et al. The significance of transient ischemic dilation in the setting of otherwise normal SPECT radionuclide myocardial perfusion images. J Nucl Cardiol 2011;18:220-9.CrossRefPubMed
16.
go back to reference Mandour Ali MA, Bourque JM, Allam AH, Beller GA, Watson DD. The prevalence and predictive accuracy of quantitatively defined transient ischemic dilation of the left ventricle on otherwise normal SPECT myocardial perfusion imaging studies. J Nucl Cardiol 2011;18:1036-43.CrossRefPubMed Mandour Ali MA, Bourque JM, Allam AH, Beller GA, Watson DD. The prevalence and predictive accuracy of quantitatively defined transient ischemic dilation of the left ventricle on otherwise normal SPECT myocardial perfusion imaging studies. J Nucl Cardiol 2011;18:1036-43.CrossRefPubMed
17.
go back to reference Katz JS, Ruisi M, Giedd KN, Rachko M. Assessment of transient ischemic dilation (TID) ratio in gated SPECT myocardial perfusion imaging (MPI) using regadenoson, a new agent for pharmacologic stress testing. J Nucl Cardiol 2012;19:727-34.CrossRefPubMed Katz JS, Ruisi M, Giedd KN, Rachko M. Assessment of transient ischemic dilation (TID) ratio in gated SPECT myocardial perfusion imaging (MPI) using regadenoson, a new agent for pharmacologic stress testing. J Nucl Cardiol 2012;19:727-34.CrossRefPubMed
18.
go back to reference Golzar Y, Olusanya A, Pe N, Dua SG, Golzar J, et al. The significance of automatically measured transient ischemic dilation in identifying severe and extensive coronary artery disease in regadenoson, single-isotope technetium-99m myocardial perfusion SPECT. J Nucl Cardiol 2015;22:526-34.CrossRefPubMed Golzar Y, Olusanya A, Pe N, Dua SG, Golzar J, et al. The significance of automatically measured transient ischemic dilation in identifying severe and extensive coronary artery disease in regadenoson, single-isotope technetium-99m myocardial perfusion SPECT. J Nucl Cardiol 2015;22:526-34.CrossRefPubMed
19.
go back to reference McClellan JR, Travin MI, Herman SD, Baron JI, Golub RJ, Gallagher JJ, et al. Prognostic importance of scintigraphic left ventricular cavity dilation during intravenous dipyridamole technetium-99m sestamibi myocardial tomographic imaging in predicting coronary events. Am J Cardiol 1997;79:600-5.CrossRefPubMed McClellan JR, Travin MI, Herman SD, Baron JI, Golub RJ, Gallagher JJ, et al. Prognostic importance of scintigraphic left ventricular cavity dilation during intravenous dipyridamole technetium-99m sestamibi myocardial tomographic imaging in predicting coronary events. Am J Cardiol 1997;79:600-5.CrossRefPubMed
20.
go back to reference Rischpler C, Higuchi T, Fukushima K, Javadi MS, Merrill J, Nekolla SG, et al. Transient ischemic dilation ratio in 82Rb PET myocardial perfusion imaging: Normal values and significance as a diagnostic and prognostic marker. J Nucl Med 2012;53:723-30.CrossRefPubMed Rischpler C, Higuchi T, Fukushima K, Javadi MS, Merrill J, Nekolla SG, et al. Transient ischemic dilation ratio in 82Rb PET myocardial perfusion imaging: Normal values and significance as a diagnostic and prognostic marker. J Nucl Med 2012;53:723-30.CrossRefPubMed
21.
go back to reference Petretta M, Acampa W, Daniele S, Petretta MP, Plaitano M, Cuocolo A. Transient ischemic dilation in patients with diabetes mellitus: Prognostic value and effect on clinical outcome after coronary revascularization. Circulation 2013;6:908-15.PubMed Petretta M, Acampa W, Daniele S, Petretta MP, Plaitano M, Cuocolo A. Transient ischemic dilation in patients with diabetes mellitus: Prognostic value and effect on clinical outcome after coronary revascularization. Circulation 2013;6:908-15.PubMed
22.
go back to reference Chavoshi M, Fard-Esfahani A, Fallahi B, Emami-Ardekani A, Beiki D, Hassanzadeh-Rad A, et al. Assessment of prognostic value of semiquantitative parameters on gated single photon emission computed tomography myocardial perfusion scintigraphy in a large middle eastern population. Indian J Nucl Med 2015;30:233-8.CrossRefPubMedPubMedCentral Chavoshi M, Fard-Esfahani A, Fallahi B, Emami-Ardekani A, Beiki D, Hassanzadeh-Rad A, et al. Assessment of prognostic value of semiquantitative parameters on gated single photon emission computed tomography myocardial perfusion scintigraphy in a large middle eastern population. Indian J Nucl Med 2015;30:233-8.CrossRefPubMedPubMedCentral
23.
go back to reference Abidov A, Bax JJ, Hayes SW, Hachamovitch R, Cohen I, Gerlach J, et al. Transient ischemic dilation ratio of the left ventricle is a significant predictor of future cardiac events in patients with otherwise normal myocardial perfusion SPECT. J Am Coll Cardiol 2003;42:1818-25.CrossRefPubMed Abidov A, Bax JJ, Hayes SW, Hachamovitch R, Cohen I, Gerlach J, et al. Transient ischemic dilation ratio of the left ventricle is a significant predictor of future cardiac events in patients with otherwise normal myocardial perfusion SPECT. J Am Coll Cardiol 2003;42:1818-25.CrossRefPubMed
24.
go back to reference Doukky R, Frogge N, Bayissa YA, Balakrishnan G, Skelton JM, Confer K, et al. The prognostic value of transient ischemic dilatation with otherwise normal SPECT myocardial perfusion imaging: A cautionary note in patients with diabetes and coronary artery disease. J Nucl Cardiol 2013;20:774-84.CrossRefPubMed Doukky R, Frogge N, Bayissa YA, Balakrishnan G, Skelton JM, Confer K, et al. The prognostic value of transient ischemic dilatation with otherwise normal SPECT myocardial perfusion imaging: A cautionary note in patients with diabetes and coronary artery disease. J Nucl Cardiol 2013;20:774-84.CrossRefPubMed
Metadata
Title
Prognostic impact of TID in regadenoson MPI: Some patients and certain events
Authors
Adrián I. Löffler, MD
Jamieson M. Bourque, MD, MHS
Publication date
01-10-2016
Publisher
Springer US
Published in
Journal of Nuclear Cardiology / Issue 5/2016
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-015-0299-9

Other articles of this Issue 5/2016

Journal of Nuclear Cardiology 5/2016 Go to the issue

Nuclear Cardiology in the Literature

A selection of recent, original research papers