Analysis of the 17-segment left ventricle model using generalized estimating equations

Excerpt

Consider the problem of comparing imaging techniques where the study design is such that a participant is subjected to both techniques. If the outcome of interest is such that each technique results in only one observation per participant, most of the commonly used standard methods of statistical data analyses may be applicable. However, an added complication to the analysis occurs when the outcome of interest from the imaging techniques that are being compared results in multiple observations per subject. In particular, researchers following the 17-segment left ventricular model (recommended by the American Heart Association1) who are interested in the outcomes at the segment level have to deal with 17 observations per subject in the analyses. …