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Journal of Nuclear Cardiology

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01-06-2014 | Original Article

Impact of point spread function modeling and time-of-flight on myocardial blood flow and myocardial flow reserve measurements for rubidium-82 cardiac PET

Authors: Ian S. Armstrong, MSc, Christine M. Tonge, MSc, Parthiban Arumugam, MD

Published in: Journal of Nuclear Cardiology | Issue 3/2014

Abstract

Background

Myocardial flow reserve (MFR) obtained from dynamic cardiac positron emission tomography (PET) with rubidium-82 (Rb-82) has been shown to be a useful measurement in assessing coronary artery disease. Advanced PET reconstructions with point spread function modeling and time-of-flight have been shown to improve image quality but also have an impact on kinetic analysis of dynamic data. This study aims to determine the impact of these algorithms on MFR data.

Methods

Dynamic Rb-82 cardiac PET images from 37 patients were reconstructed with standard and advanced reconstructions. Area under curve (AUC) of the blood input function (BIF), myocardial blood flow (MBF) and MFR were compared with each reconstruction.

Results

No significant differences were seen in MFR for the two reconstructions. A relatively small mean difference in MBF data of +11.9% was observed with advanced reconstruction compared with the standard reconstruction but there was considerable variability in the degree of change (95% confidence intervals of −16.2% to +40.0%). Small systematic relative differences were seen for AUC BIF (mean difference of −6.3%; 95% CI −17.5% to +5.4%).

Conclusion:

MFR results from Rb-82 dynamic PET appear to be robust when generated by standard or advanced PET reconstructions. Considerable increases in MBF values may occur with advanced reconstructions, and further work is required to fully understand this.

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Title: Impact of point spread function modeling and time-of-flight on myocardial blood flow and myocardial flow reserve measurements for rubidium-82 cardiac PET
Authors: Ian S. Armstrong, MSc
Christine M. Tonge, MSc
Parthiban Arumugam, MD
Publication date: 01-06-2014
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 3/2014
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-014-9858-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of point spread function modeling and time-of-flight on myocardial blood flow and myocardial flow reserve measurements for rubidium-82 cardiac PET

Abstract

Background

Methods

Results

Conclusion:

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion:

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