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01-04-2014 | Original Article

Delayed sodium ¹⁸F-fluoride PET/CT imaging does not improve quantification of vascular calcification metabolism: Results from the CAMONA study

Authors: Björn A. Blomberg, MD, MSc, Anders Thomassen, MD, Richard A. P. Takx, MD, MSc, Mie H. Vilstrup, MD, Søren Hess, MD, Anne L. Nielsen, MD, Axel C. P. Diederichsen, MD, PhD, Hans Mickley, MD, DMSc, Abass Alavi, MD, PhD, DSc, Poul F. Høilund-Carlsen, MD, DMSc

Published in: Journal of Nuclear Cardiology | Issue 2/2014

Abstract

Background

This study aimed to determine if delayed sodium ¹⁸F-fluoride (Na¹⁸F) PET/CT imaging improves quantification of vascular calcification metabolism. Blood-pool activity can disturb the arterial Na¹⁸F signal. With time, blood-pool activity declines. Therefore, delayed imaging can potentially improve quantification of vascular calcification metabolism.

Methods and Results

Twenty healthy volunteers and 18 patients with chest pain were prospectively assessed by triple time-point PET/CT imaging at approximately 45, 90, and 180 minutes after Na¹⁸F administration. For each time point, global uptake of Na¹⁸F was determined in the coronary arteries and thoracic aorta by calculating the blood-pool-corrected maximum standardized uptake value (cSUV_MAX). A target-to-background ratio (TBR) was calculated to determine the contrast resolution at 45, 90, and 180 minutes. Furthermore, we assessed whether the acquisition time-point affected the relation between cSUV_MAX and the estimated 10-year risk for fatal cardiovascular disease (SCORE %). Coronary cSUV_MAX (P = .533) and aortic cSUV_MAX (P = .654) remained similar with time, whereas the coronary TBR (P < .0001) and aortic TBR (P < .0001) significantly increased with time. Even though the contrast resolution improved with time, positive correlations between SCORE % and coronary cSUV_MAX (P < .020) and aortic cSUV_MAX (P < .005) were observed at all investigated time points.

Conclusions

Delayed Na¹⁸F PET/CT imaging does not improve quantification of vascular calcification metabolism. Although contrast resolution improves with time, arterial Na¹⁸F avidity is invariant to the time between Na¹⁸F administration and PET/CT acquisition. Therefore, the optimal PET/CT acquisition time-point to quantify vascular calcification metabolism is achieved as early as 45 minutes after Na¹⁸F administration.

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Title: Delayed sodium 18F-fluoride PET/CT imaging does not improve quantification of vascular calcification metabolism: Results from the CAMONA study
Authors: Björn A. Blomberg, MD, MSc
Anders Thomassen, MD
Richard A. P. Takx, MD, MSc
Mie H. Vilstrup, MD
Søren Hess, MD
Anne L. Nielsen, MD
Axel C. P. Diederichsen, MD, PhD
Hans Mickley, MD, DMSc
Abass Alavi, MD, PhD, DSc
Poul F. Høilund-Carlsen, MD, DMSc
Publication date: 01-04-2014
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 2/2014
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-013-9829-5

2024 ASCO Annual Meeting

Springer Medicine

Delayed sodium ¹⁸F-fluoride PET/CT imaging does not improve quantification of vascular calcification metabolism: Results from the CAMONA study

Abstract

Background

Methods and Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods and Results

Conclusions

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