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Published in: Advances in Therapy 10/2013

01-10-2013 | Original Research

Improvement of Glycemic Control by Re-education in Insulin Injection Technique in Patients with Diabetes Mellitus

Authors: Yuki Nakatani, Mihoko Matsumura, Tsuyoshi Monden, Yoshimasa Aso, Takaaki Nakamoto

Published in: Advances in Therapy | Issue 10/2013

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Abstract

Introduction

The aim of this study was to evaluate the effectiveness of re-education in the insulin injection technique for glycemic control.

Methods

A preliminary experimental study was performed with 87 insulin-treated diabetic outpatients (11 with type 1 diabetes, 76 with type 2 diabetes; 43 men, 44 women). All patients had been treated with insulin for more than 3 years. After answering questions about the insulin injection technique, the patients’ knowledge levels were scored. Correct answers and explanation sheets were subsequently given to all patients. The physicians in charge gave a short lecture and provided 10 min of individual advice. Two, three, and four months after re-education the HbA1c and glycoalbumin levels were measured.

Results

The mean HbA1c levels of almost all patients significantly improved from 7.46 ± 0.09% to 6.73 ± 0.10% (P < 0.01), and the mean glycoalbumin levels significantly improved from 22.76 ± 0.50% to 20.26 ± 0.68% (P < 0.01). Twenty-five patients demonstrated a poor understanding (score of ≤6 points) and showed a significant decrease in the HbA1c level from 7.62 ± 0.20% to 6.71 ± 0.21% (P = 0.02). Forty-three patients demonstrated a moderate understanding (score of 7 or 8 points) and showed a decrease in the HbA1c level from 7.40 ± 0.13% to 6.68 ± 0.07% (P = 0.07). Finally, 19 patients demonstrated a good understanding (score of ≥9 points) and showed a slight decrease in the HbA1c level from 7.38 ± 0.15% to 6.93 ± 0.12% (P = 0.09). Patients with a poor understanding showed the largest decrease in the mean level of HbA1c.

Conclusion

Re-education in the insulin injection technique led to an improvement in glycemic control in insulin-treated diabetic patients, especially in those with a poor understanding of the insulin injection technique. More attention should be paid to these strategies for outpatients.
Literature
1.
go back to reference Yki-Jarvinen H, Kauppila M, Kujansuu E, et al. Comparison of insulin regimen in patients with non-insulin-dependent diabetes mellitus. N Eng J Med. 1992;327:1426–33.CrossRef Yki-Jarvinen H, Kauppila M, Kujansuu E, et al. Comparison of insulin regimen in patients with non-insulin-dependent diabetes mellitus. N Eng J Med. 1992;327:1426–33.CrossRef
2.
go back to reference The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977–86.CrossRef The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977–86.CrossRef
3.
go back to reference Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetes microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995;28(2):103–17.PubMedCrossRef Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetes microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract. 1995;28(2):103–17.PubMedCrossRef
6.
go back to reference Ohara T, Masato K. Topics of insulin therapy—ultra rapid-acting and development of ultra-long-acting insulin [in Japanese]. J Jpn Med Assoc. 2002;128(10):1530–1. Ohara T, Masato K. Topics of insulin therapy—ultra rapid-acting and development of ultra-long-acting insulin [in Japanese]. J Jpn Med Assoc. 2002;128(10):1530–1.
7.
go back to reference Frida A, Hirsch L, Gaspar R, et al. The Third Injection Technique Workshop in Athens (TITAN). Diabetes Metab. 2010;36:S19–29.CrossRef Frida A, Hirsch L, Gaspar R, et al. The Third Injection Technique Workshop in Athens (TITAN). Diabetes Metab. 2010;36:S19–29.CrossRef
8.
go back to reference De Coninck C, Frid A, et al. Results and analysis of the 2008–2009 Insulin Injection Technique Questionnaire survey. J Diabetes 2010;2:168–79. De Coninck C, Frid A, et al. Results and analysis of the 2008–2009 Insulin Injection Technique Questionnaire survey. J Diabetes 2010;2:168–79.
9.
go back to reference Hamaguchi T, Namba M. Insulin treatment in elder patients with diabetes. Nihon Rinsho. 2006;64(1):101–5.PubMed Hamaguchi T, Namba M. Insulin treatment in elder patients with diabetes. Nihon Rinsho. 2006;64(1):101–5.PubMed
10.
go back to reference Hirsch L, Gaspar R, et al. New injection recommendations for patients with diabetes. Diabetes Metab. 2010;38:S3–18. Hirsch L, Gaspar R, et al. New injection recommendations for patients with diabetes. Diabetes Metab. 2010;38:S3–18.
11.
go back to reference Kawamori R, Matsuhira M, Yamasaki Y. The biology of insulin action in diabetes. In: Turtle JR, Kaneko T, Osato S, editors. Diabetes in the new millennium. Sydney: University of Sydney Press; 1999. p. 73–84. Kawamori R, Matsuhira M, Yamasaki Y. The biology of insulin action in diabetes. In: Turtle JR, Kaneko T, Osato S, editors. Diabetes in the new millennium. Sydney: University of Sydney Press; 1999. p. 73–84.
12.
go back to reference Asakura T, Seino H. Air that was mixed into the insulin cartridge inside (bubble)—the effect that gives the accuracy of the pen-type insulin injection device [in Japanese]. J Jpn Diabete Soc. 2004;47:391–4. Asakura T, Seino H. Air that was mixed into the insulin cartridge inside (bubble)—the effect that gives the accuracy of the pen-type insulin injection device [in Japanese]. J Jpn Diabete Soc. 2004;47:391–4.
13.
go back to reference American Diabetes Association. Insulin administration: clinical practice recommendation 2000. Diabete Care. 2001;24(suppl1):S94–7. American Diabetes Association. Insulin administration: clinical practice recommendation 2000. Diabete Care. 2001;24(suppl1):S94–7.
15.
go back to reference Koivisto VA, Felig P. Alterations in insulin absorption and in blood glucose control associated with varying insulin injection sites in diabetic patients. Ann Intern Med. 1980;92:59–61.PubMedCrossRef Koivisto VA, Felig P. Alterations in insulin absorption and in blood glucose control associated with varying insulin injection sites in diabetic patients. Ann Intern Med. 1980;92:59–61.PubMedCrossRef
16.
go back to reference Koivisto VA, Felig P. Effects of leg exercise on insulin absorption in diabetic patients. N Engl J Med. 1978;298:79–83.PubMedCrossRef Koivisto VA, Felig P. Effects of leg exercise on insulin absorption in diabetic patients. N Engl J Med. 1978;298:79–83.PubMedCrossRef
17.
go back to reference Berger M, Halban PA, Assal JP, Offord RE, Vranic M, Renold AE. Pharmacokinetics of subcutaneously injected tritiated insulin: effects of exercise. Diabetes. 1979;28:53–6.PubMedCrossRef Berger M, Halban PA, Assal JP, Offord RE, Vranic M, Renold AE. Pharmacokinetics of subcutaneously injected tritiated insulin: effects of exercise. Diabetes. 1979;28:53–6.PubMedCrossRef
18.
go back to reference Koivisto VA, Fortney S, Hendler R, Felig P. A rise in ambient temperature augments insulin absorption in diabetic patients. Metabolism. 1981;30:402–5.PubMedCrossRef Koivisto VA, Fortney S, Hendler R, Felig P. A rise in ambient temperature augments insulin absorption in diabetic patients. Metabolism. 1981;30:402–5.PubMedCrossRef
19.
go back to reference Berger M, Cuppers HJ, Hegner H, Jorgens V, Berchtold P. Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care. 1982;5:77–91.PubMedCrossRef Berger M, Cuppers HJ, Hegner H, Jorgens V, Berchtold P. Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care. 1982;5:77–91.PubMedCrossRef
20.
go back to reference Koivisto VA. Sauna-induced acceleration in insulin absorption from subcutaneous injection site. Br Med J. 1980;298:1411–3.CrossRef Koivisto VA. Sauna-induced acceleration in insulin absorption from subcutaneous injection site. Br Med J. 1980;298:1411–3.CrossRef
21.
go back to reference Zehrer C, Hansen R, Bantle J. Reducing blood glucose variability by use of abdominal insulin injection sites. Diabetes Educ. 1990;16(6):474–7.PubMedCrossRef Zehrer C, Hansen R, Bantle J. Reducing blood glucose variability by use of abdominal insulin injection sites. Diabetes Educ. 1990;16(6):474–7.PubMedCrossRef
22.
go back to reference Kordonouri O, Lauterborn R, Deiss D. Lipohypertrophy in young patients with type 1 diabetes. Diabetes Care. 2002;25(3):643.CrossRef Kordonouri O, Lauterborn R, Deiss D. Lipohypertrophy in young patients with type 1 diabetes. Diabetes Care. 2002;25(3):643.CrossRef
23.
go back to reference Hauner H, Stockamo B, et al. Prevalence of lipohypertrophy in insulin-treated diabetic patients and predisposing factors. Exp Clin Endocrinol Diabetes. 1996;104:106–10.PubMedCrossRef Hauner H, Stockamo B, et al. Prevalence of lipohypertrophy in insulin-treated diabetic patients and predisposing factors. Exp Clin Endocrinol Diabetes. 1996;104:106–10.PubMedCrossRef
24.
go back to reference McNally PG, Jowett NI, et al. Lipohypertrophy and lipoatrophy complicating treatment with highly purified bovine and porcine insulins. Postgrad Med J. 1988;64(757):850–3.PubMedCrossRef McNally PG, Jowett NI, et al. Lipohypertrophy and lipoatrophy complicating treatment with highly purified bovine and porcine insulins. Postgrad Med J. 1988;64(757):850–3.PubMedCrossRef
25.
go back to reference American Diabetes Association. Insulin administration. Diabetes Care. 2001;24:1984–7.CrossRef American Diabetes Association. Insulin administration. Diabetes Care. 2001;24:1984–7.CrossRef
26.
go back to reference Strauss K, Hannet I, et al. Ultra-short (5 mm) insulin needles: trial results and clinical recommendations. Pract Diabetes Int. 1999;16:218–22.CrossRef Strauss K, Hannet I, et al. Ultra-short (5 mm) insulin needles: trial results and clinical recommendations. Pract Diabetes Int. 1999;16:218–22.CrossRef
27.
go back to reference Milicevic Z, Profozic V, Wyatt J, et al. Intramuscular injection of insulin lispro or soluble human insulin: pharmacokinetics and glucodynamics in Type 2 diabetes. Diabetes Med. 2001;18(7):562–6.CrossRef Milicevic Z, Profozic V, Wyatt J, et al. Intramuscular injection of insulin lispro or soluble human insulin: pharmacokinetics and glucodynamics in Type 2 diabetes. Diabetes Med. 2001;18(7):562–6.CrossRef
28.
go back to reference Annersten M, Frid A. Insulin pens dribble from the tip of the needle after injection. Pract Diabetes Int. 2000;17:109–11.CrossRef Annersten M, Frid A. Insulin pens dribble from the tip of the needle after injection. Pract Diabetes Int. 2000;17:109–11.CrossRef
29.
go back to reference Le Floch JP, Herbreteau C, Lange F, Perlemuter L. Biologic material in needles and cartridges after insulin injection with a pen in diabetic patients. Diabetes Care. 1998;21:1502–4.PubMedCrossRef Le Floch JP, Herbreteau C, Lange F, Perlemuter L. Biologic material in needles and cartridges after insulin injection with a pen in diabetic patients. Diabetes Care. 1998;21:1502–4.PubMedCrossRef
30.
go back to reference Hunt LM, Valenzuela MA, Pugh JA. NIDDM patients’ fears and hopes about insulin therapy. Diabetes Care. 1997;20:292–8.PubMedCrossRef Hunt LM, Valenzuela MA, Pugh JA. NIDDM patients’ fears and hopes about insulin therapy. Diabetes Care. 1997;20:292–8.PubMedCrossRef
31.
go back to reference Schiel R, Mullar UA, Ulbrich S. Long-term efficacy of a 5-day structured teaching and treatment programme for intensified conventional insulin therapy and risk for severe hypoglycemia. Diabetes Res Clin Pract. 1997;35:41–8.PubMedCrossRef Schiel R, Mullar UA, Ulbrich S. Long-term efficacy of a 5-day structured teaching and treatment programme for intensified conventional insulin therapy and risk for severe hypoglycemia. Diabetes Res Clin Pract. 1997;35:41–8.PubMedCrossRef
Metadata
Title
Improvement of Glycemic Control by Re-education in Insulin Injection Technique in Patients with Diabetes Mellitus
Authors
Yuki Nakatani
Mihoko Matsumura
Tsuyoshi Monden
Yoshimasa Aso
Takaaki Nakamoto
Publication date
01-10-2013
Publisher
Springer Healthcare
Published in
Advances in Therapy / Issue 10/2013
Print ISSN: 0741-238X
Electronic ISSN: 1865-8652
DOI
https://doi.org/10.1007/s12325-013-0066-8

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