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09-11-2023 | Lymphadenopathy | Original Article

Increased IgG4+ plasma cells are common in excised lymph nodes from children and adolescents without IgG4-related disease

Authors: Rachel M. Whitehair, Nadine S. Aguilera, Patcharin Pramoonjago, Jeffrey W. Craig

Published in: Journal of Hematopathology | Issue 4/2023

Abstract

Lymphadenopathy is a common finding in patients with IgG4-related disease (IgG4-RD) and often associated with increased IgG4+ plasma cells in this setting. The histologic features of so-called IgG4-related lymphadenopathy (IgG4-LAD) have seldom been investigated in children and adolescents, and step-wise progression to extranodal IgG4-RD has not been described. This study was performed to further evaluate the frequency, pathologic features, and clinical significance of IgG4-LAD-like histologic changes in the pediatric setting. We analyzed 37 benign lymph nodes collected semi-consecutively from children aged 0–18 years at our institution for both absolute and relative IgG4+ plasma cell abundance and recurrent histomorphologic patterns associated with IgG4-LAD. The combination of IgG4+/IgG+ plasma cell ratio >40% and IgG4+ plasma cell count ≥50 were considered as IgG4-LAD-like per expert consensus guidelines. Seven cases (19%) met both diagnostic criteria. The dominant histomorphologic patterns were follicular hyperplasia (n = 6), interfollicular expansion (n = 3), and progressive transformation of germinal centers (n = 3). Extranodal manifestations of IgG4-RD were not identified in this cohort (38 months average follow-up). Instead, clinical and laboratory findings indicated that lymph node enlargement in most patients could likely be attributed to alternative processes including antecedent dentistry, concurrent infection, and incipient Crohn’s disease. Our findings suggest that the histologic features of IgG4-LAD are likely much more common in children and adolescents than previously recognized, often existing in complex with common reactive lymphadenopathies. The diagnostic value of routine immunohistochemical assessment for IgG4+ plasma cells in benign lymph nodes from pediatric patients without established extranodal IgG4-RD and/or other supportive clinical and laboratory data is therefore uncertain.

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Title: Increased IgG4+ plasma cells are common in excised lymph nodes from children and adolescents without IgG4-related disease
Authors: Rachel M. Whitehair
Nadine S. Aguilera
Patcharin Pramoonjago
Jeffrey W. Craig
Publication date: 09-11-2023
Publisher: Springer Berlin Heidelberg
Keywords: Lymphadenopathy
Crohn's Disease
Histoplasmosis
Published in: Journal of Hematopathology / Issue 4/2023
Print ISSN: 1868-9256
Electronic ISSN: 1865-5785
DOI: https://doi.org/10.1007/s12308-023-00565-4

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Increased IgG4+ plasma cells are common in excised lymph nodes from children and adolescents without IgG4-related disease

Abstract

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