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Open Access 01-12-2008 | Review Paper

Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer

Authors: Stéphanie Gout, Jacques Huot

Published in: Cancer Microenvironment | Issue 1/2008

Abstract

One person on three will receive a diagnostic of cancer during his life. About one third of them will die of the disease. In most cases, death will result from the formation of distal secondary sites called metastases. Several events that lead to cancer are under genetic control. In particular, cancer initiation is tightly associated with specific mutations that affect proto-oncogenes and tumour suppressor genes. These mutations lead to unrestrained growth of the primary neoplasm and a propensity to detach and to progress through the subsequent steps of metastatic dissemination. This process depends tightly on the surrounding microenvironment. In fact, several studies support the point that tumour development relies on a continuous cross-talk between cancer cells and their cellular and extracellular microenvironments. This signaling cross-talk is mediated by transmembrane receptors expressed on cancer cells and stromal cells. The aim of this manuscript is to review how the cancer microenvironment influences the journey of a metastatic cell taking liver invasion by colorectal cancer cells as a model.

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Title: Role of Cancer Microenvironment in Metastasis: Focus on Colon Cancer
Authors: Stéphanie Gout
Jacques Huot
Publication date: 01-12-2008
Publisher: Springer Netherlands
Published in: Cancer Microenvironment / Issue 1/2008
Print ISSN: 1875-2292
Electronic ISSN: 1875-2284
DOI: https://doi.org/10.1007/s12307-008-0007-2

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Emerging Roles of PAR-1 and PAFR in Melanoma Metastasis

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Sialyl Lewis X Expression and Lymphatic Microvessel Density in Primary Tumors of Node-negative Colorectal Cancer Patients Predict Disease Recurrence

The Prometastatic Microenvironment of the Liver

Significance of Toll-like Receptors Expression in Tumor Growth and Spreading: A Short Review

Keynote webinar | Spotlight on antibody–drug conjugates in cancer