Unusual Sites of Auer Rod in AML with t(8;21)

Excerpt

A 37-year-old woman was admitted to our hospital with fever for 3 days. She had a history of gestational hypertension and psoriasis. Her peripheral blood cell count showed 75 g/L hemoglobin, 51 × 10⁹/L platelets, and 5.5 × 10⁹/L leukocytes. The differential count showed 22% neutrophils, 15% lymphocytes, 2% eosinophils, 10% monocytes, and 51% blasts. Bone marrow aspiration with Wright-Giemsa stained revealed hypercellularity with 53% blasts and eosinophilia (12%), as well as numerous Auer rods in eosinophils, sea-blue cells, and phagocytes (Fig. 1a–d; original magnification 1000 ×). Flow cytometry analysis demonstrated blasts positive for CD33, CD13, cMPO, HLA-DR, CD117, CD34, CD38. The cytogenetics test found a 45, X, −X, t(8:21) (q22;q22)[20] karyotype, and molecular study showed RUNX1–RUNX1T1 rearrangement suggestive of AML with t(8;21).

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