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01-01-2008 | Special Feature: Original Article

Patients’ subjective evaluation of early and late sequelae in patients with breast cancer irradiated with short fractionation for breast conservation therapy: comparison with conventional fractionation

Authors: Taisuke Inomata, Isamu Narabayashi, Yuki Inada, Taiju Shimbo, Masatsugu Takahashi, Toshiaki Tatsumi, Yasuo Uesugi, Shinji Kariya, Akihito Nishioka, Yasuhiro Ogawa

Published in: Breast Cancer | Issue 1/2008

Abstract

Background

To compare the frequency of “subjective” complications and their severity between conventional and short fractionation and to analyze the differences between the two groups.

Methods

Data from 350 patients with breast cancer who received breast conservation therapy between 1992 and 2003 were retrospectively analyzed. One hundred and ninety-six patients and 154 patients received 50 Gy in 25 fractions over 35 days (group C) and 44 Gy in 16 fractions over 22 days (group S), respectively. Early sequelae were evaluated at the end of radiation therapy (point A) and 7–10 days after the treatment (point B). Late sequelae were assessed at least 6 months after the end of radiation therapy (point C).

Results

The most commonly observed toxicity at point A was erythema, followed by heat sensation, sense of discomfort, and pain. There were no significant differences in these symptoms between the two groups. The frequency of these symptoms hardly changed between points A and B. At point C a sense of hardness more frequently appeared in group S than in group C with a significant difference. Other commonly noted symptoms had no significant difference between the two groups.

Conclusions

Short fractionation results in acceptable patient “subjective” sequelae comparable to the sequelae experienced following conventional fractionation.

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Title: Patients’ subjective evaluation of early and late sequelae in patients with breast cancer irradiated with short fractionation for breast conservation therapy: comparison with conventional fractionation
Authors: Taisuke Inomata
Isamu Narabayashi
Yuki Inada
Taiju Shimbo
Masatsugu Takahashi
Toshiaki Tatsumi
Yasuo Uesugi
Shinji Kariya
Akihito Nishioka
Yasuhiro Ogawa
Publication date: 01-01-2008
Publisher: Springer Japan
Published in: Breast Cancer / Issue 1/2008
Print ISSN: 1340-6868
Electronic ISSN: 1880-4233
DOI: https://doi.org/10.1007/s12282-007-0011-2

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