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Journal of Cardiovascular Translational Research

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Open Access 01-12-2013

Long Noncoding RNA: a New Player of Heart Failure?

Authors: Roberto Papait, Paolo Kunderfranco, Giuliano Giuseppe Stirparo, Michael V. G. Latronico, Gianluigi Condorelli

Published in: Journal of Cardiovascular Translational Research | Issue 6/2013

Abstract

One the most important discoveries of the post-genomic era is that a large fraction of the genome transcribes a heterogeneous population of noncoding RNAs (ncRNA). ncRNAs shorter than 200 nucleotides are usually identified as short/small ncRNAs—examples include PIWI-interacting RNAs, small interfering RNAs, and microRNAs (miRNAs)—whereas those longer than 200 nucleotides are classified as long ncRNAs (lncRNAs). These molecules are emerging as important regulators of cellular process, such as development, differentiation, and metabolism. Not surprisingly, ncRNAs are involved also in human diseases, such as cancer and metabolic and neuronal disorders. Although the role of miRNAs is being largely investigated in cardiovascular biology, little is known about other classes of ncRNA in this field. However, recent reports have started to reveal the importance of lncRNA in heart development and suggest also an involvement in heart failure. Here, we will discuss these reports and the therapeutic potential of lncRNA for heart failure.

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Title: Long Noncoding RNA: a New Player of Heart Failure?
Authors: Roberto Papait
Paolo Kunderfranco
Giuliano Giuseppe Stirparo
Michael V. G. Latronico
Gianluigi Condorelli
Publication date: 01-12-2013
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 6/2013
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-013-9488-6

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Long Noncoding RNA: a New Player of Heart Failure?

Abstract

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Abstract

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