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Journal of Cardiovascular Translational Research
Published in: Journal of Cardiovascular Translational Research 4/2011

01-08-2011

Emerging MRI Methods in Translational Cardiovascular Research

Authors: Moriel H. Vandsburger, Frederick H. Epstein

Published in: Journal of Cardiovascular Translational Research | Issue 4/2011

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Abstract

Cardiac magnetic resonance imaging (CMR) has become a reference standard modality for imaging of left ventricular (LV) structure and function and, using late gadolinium enhancement, for imaging myocardial infarction. Emerging CMR techniques enable a more comprehensive examination of the heart, making CMR an excellent tool for use in translational cardiovascular research. Specifically, emerging CMR methods have been developed to measure the extent of myocardial edema, changes in ventricular mechanics, changes in tissue composition as a result of fibrosis, and changes in myocardial perfusion as a function of both disease and infarct healing. New CMR techniques also enable the tracking of labeled cells, molecular imaging of biomarkers of disease, and changes in calcium flux in cardiomyocytes. In addition, MRI can quantify blood flow velocity and wall shear stress in large blood vessels. Almost all of these techniques can be applied in both pre-clinical and clinical settings, enabling both the techniques themselves and the knowledge gained using such techniques in pre-clinical research to be translated from the lab bench to the patient bedside.
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Metadata
Title
Emerging MRI Methods in Translational Cardiovascular Research
Authors
Moriel H. Vandsburger
Frederick H. Epstein
Publication date
01-08-2011
Publisher
Springer US
Published in
Journal of Cardiovascular Translational Research / Issue 4/2011
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-011-9275-1

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