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Journal of Cardiovascular Translational Research

Published in:

01-06-2010

MicroRNAs in Vascular Biology and Vascular Disease

Author: Chunxiang Zhang

Published in: Journal of Cardiovascular Translational Research | Issue 3/2010

Abstract

MicroRNAs (miRNAs) have emerged as a novel class of endogenous, small, non-coding RNAs that negatively regulate over 30% of genes in a cell via degradation or translational inhibition of their target mRNAs. Functionally, an individual miRNA is important as a transcription factor because it is able to regulate the expression of its multiple target genes. Recent studies have identified that miRNAs are highly expressed in vasculature and their expression is deregulated in diseased vessels. miRNAs are found to be critical modulators for vascular cell functions such as cell differentiation, migration, proliferation, and apoptosis. Accordingly, miRNAs are involved in the angiogenesis and in the pathogenesis of vascular diseases. miRNAs may serve as novel biomarkers and therapeutic targets for vascular disease. This review article summarizes the research progress regarding the roles of miRNAs in vascular biology and vascular disease.

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Title: MicroRNAs in Vascular Biology and Vascular Disease
Author: Chunxiang Zhang
Publication date: 01-06-2010
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 3/2010
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-010-9164-z

2024 ASCO Annual Meeting

Springer Medicine

MicroRNAs in Vascular Biology and Vascular Disease

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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