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01-02-2017 | Review

A New Perspective for Parkinson’s Disease: Circadian Rhythm

Authors: Siyue Li, Yali Wang, Fen Wang, Li-Fang Hu, Chun-Feng Liu

Published in: Neuroscience Bulletin | Issue 1/2017

Abstract

Circadian rhythm is manifested by the behavioral and physiological changes from day to night, which is controlled by the pacemaker and its regulator. The former is located at the suprachiasmatic nuclei (SCN) in the anterior hypothalamus, while the latter is composed of clock genes present in all tissues. Circadian desynchronization influences normal patterns of day-night rhythms such as sleep and alertness cycles, rest and activity cycles. Parkinson’s disease (PD) exhibits diurnal fluctuations. Circadian dysfunction has been observed in PD patients and animal models, which may result in negative consequences to the homeostasis and even exacerbate the disease progression. Therefore, circadian therapies, including light stimulation, physical activity, dietary and social schedules, may be helpful for PD patients. However, the cellular and molecular mechanisms that underlie the circadian dysfunction in PD remain elusive. Further research on circadian patterns is needed. This article summarizes the existing research on the circadian rhythms in PD, focusing on the clinical symptom variations, molecular changes, as well as the available treatment options.

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Title: A New Perspective for Parkinson’s Disease: Circadian Rhythm
Authors: Siyue Li
Yali Wang
Fen Wang
Li-Fang Hu
Chun-Feng Liu
Publication date: 01-02-2017
Publisher: Springer Singapore
Published in: Neuroscience Bulletin / Issue 1/2017
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-016-0089-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A New Perspective for Parkinson’s Disease: Circadian Rhythm

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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Intracellular TG2 Activity Increases Microtubule Stability but is not Sufficient to Prompt Neurite Growth

Transcriptional and Epigenetic Regulation in Injury-Mediated Neuronal Dendritic Plasticity

Neuroglial Crosstalk by Mitochondria

A New Link Between Insulin Signaling and Fragile X Syndrome

A Longer Siesta? DN1s in Control!

MPTP Induces Systemic Parkinsonism in Middle-Aged Cynomolgus Monkeys: Clinical Evolution and Outcomes