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Neuroscience Bulletin
Published in: Neuroscience Bulletin 2/2016

01-04-2016 | Review

Insular Cortex is Critical for the Perception, Modulation, and Chronification of Pain

Authors: Changbo Lu, Tao Yang, Huan Zhao, Ming Zhang, Fancheng Meng, Hao Fu, Yingli Xie, Hui Xu

Published in: Neuroscience Bulletin | Issue 2/2016

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Abstract

An increasing body of neuroimaging and electrophysiological studies of the brain suggest that the insular cortex (IC) integrates multimodal salient information ranging from sensation to cognitive-affective events to create conscious interoception. Especially with regard to pain experience, the IC has been supposed to participate in both sensory-discriminative and affective-motivational aspects of pain. In this review, we discuss the latest data proposing that subregions of the IC are involved in isolated pain networks: the posterior sensory circuit and the anterior emotional network. Due to abundant connections with other brain areas, the IC is likely to serve as an interface where cross-modal shaping of pain occurs. In chronic pain, however, this mode of emotional awareness and the modulation of pain are disrupted. We highlight some of the molecular mechanisms underlying the changes of the pain modulation system that contribute to the transition from acute to chronic pain in the IC.
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Metadata
Title
Insular Cortex is Critical for the Perception, Modulation, and Chronification of Pain
Authors
Changbo Lu
Tao Yang
Huan Zhao
Ming Zhang
Fancheng Meng
Hao Fu
Yingli Xie
Hui Xu
Publication date
01-04-2016
Publisher
Springer Singapore
Published in
Neuroscience Bulletin / Issue 2/2016
Print ISSN: 1673-7067
Electronic ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-016-0016-y

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