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Published in: memo - Magazine of European Medical Oncology 4/2023

17-08-2023 | Glioma | short review

ASCO 2023: new treatment options in CNS tumors

Invited short review

Author: Dr. Josef Pichler

Published in: memo - Magazine of European Medical Oncology | Issue 4/2023

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Summary

Practice-changing therapy for IDH1/2–mutant diffuse glioma was presented at the meeting. Vorasidenib as an oral, brain penetrant, dual inhibitor of mutant IDH1/2 showed very promising results in the phase 3 INDIGO study. Other new treatment approaches including vaccines, immunotherapy and targeted therapy in rare von Hippel–Lindau-associated cerebral hemangioblastomas have shown progress in neuro-oncology.
Literature
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go back to reference Hartmann C, et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 2009;118:469–74.CrossRefPubMed Hartmann C, et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol. 2009;118:469–74.CrossRefPubMed
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go back to reference Wakimoto H, et al. Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas. Clin Cancer Res. 2014;20(11):2898–909.CrossRefPubMedPubMedCentral Wakimoto H, et al. Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas. Clin Cancer Res. 2014;20(11):2898–909.CrossRefPubMedPubMedCentral
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go back to reference ClinicalTrials.gov Identifier: NCT03922555; ASTX727 in Recurrent/Progressive Non enhancing IDH Mutant Gliomas ClinicalTrials.gov Identifier: NCT03922555; ASTX727 in Recurrent/Progressive Non enhancing IDH Mutant Gliomas
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go back to reference ClinicalTrials.gov Identifier: NCT05406700 Niraparib In Recurrent IDH 1/2 Gliomas ClinicalTrials.gov Identifier: NCT05406700 Niraparib In Recurrent IDH 1/2 Gliomas
Metadata
Title
ASCO 2023: new treatment options in CNS tumors
Invited short review
Author
Dr. Josef Pichler
Publication date
17-08-2023
Publisher
Springer Vienna
Published in
memo - Magazine of European Medical Oncology / Issue 4/2023
Print ISSN: 1865-5041
Electronic ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-023-00915-z

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