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Pathology & Oncology Research

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01-07-2018 | Letter to the Editor

Discordance Rate of HER2 Status in Primary Gastric Cancer and Synchronous Lymph Node Metastases: Its Impact on Therapeutic Decision and Clinical Management

Authors: A. Ieni, G. Angelico, G. Giuffrè, G. Tuccari

Published in: Pathology & Oncology Research | Issue 3/2018

Excerpt

Dear Editor, …

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Ahn S, Ahn S, Van Vrancken M et al (2015) Ideal number of biopsy tumor fragments for predicting HER2 status in gastric carcinoma resection specimens. Oncotarget 6:38372–38380PubMedPubMedCentral

Gullo I, Grillo F, Molinaro L et al (2015) Minimum biopsy set for HER2 evaluation in gastric and gastro-esophageal junction cancer. Endosc Int Open 3:E165–E170CrossRefPubMedPubMedCentral

Park SR, Park YS, Ryu MH et al (2016) Extra-gain of HER2-positive cases through HER2 reassessment in primary and metastatic sites in advanced gastric cancer with initially HER2-negative primary tumours: results of GASTric cancer HER2 reassessment study 1 (GASTHER1). Eur J Cancer 53:42–50CrossRefPubMed

Pagni F, Zannella S, Ronchi S et al (2013) HER2 status of gastric carcinoma and corresponding lymph node metastasis. Pathol Oncol Res 19:103–109CrossRefPubMed

Kochi M, Fujii M, Masuda S, et al. (2013) Differing deregulation of HER2 in primary gastric cancer and synchronous related metastatic lymph nodes. Diagn Pathol 21;8:191

Ieni A, Barresi V, Caltabiano R et al (2014) Discordance rate of HER2 status in primary breast carcinomas versus synchronous axillary lymph node metastases: a multicenter retrospective investigation. Onco Targets Ther 7:1267–1272PubMedPubMedCentral

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Ieni A, Barresi V, Caltabiano R et al (2014) Discordance rate of HER2 status in primary gastric carcinomas and synchronous lymph node metastases: a multicenter retrospective analysis. Int J Mol Sci 15:22331–22341CrossRefPubMedPubMedCentral

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Ieni A, Barresi V, Branca G et al (2015) Changes in human epidermal growth factor receptor 2 status between primary breast/gastric carcinomas and synchronous metastatic lymph nodes: how can we explain them? J Cancer Metastasis Treat 1:21–26

Title: Discordance Rate of HER2 Status in Primary Gastric Cancer and Synchronous Lymph Node Metastases: Its Impact on Therapeutic Decision and Clinical Management
Authors: A. Ieni
G. Angelico
G. Giuffrè
G. Tuccari
Publication date: 01-07-2018
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 3/2018
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-017-0276-5

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