Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Pathology & Oncology Research
Published in: Pathology & Oncology Research 1/2009

01-03-2009 | Brief Communication

Effects of Humoral Immunity and Calreticulin Overexpression on Postoperative Course in Breast Cancer

Authors: Aleksandra Erić, Zorica Juranić, Zorka Milovanović, Ivan Marković, Momčilo Inić, Nevenka Stanojević-Bakić, Vesna Vojinović-Golubović

Published in: Pathology & Oncology Research | Issue 1/2009

Login to get access

Abstract

The aim was to investigate whether the humoral immunity and overexpression of calreticulin in tumor tissue determined before surgery, correlate with incidence of metastases in breast cancer patients within two years after operation. Before operation, their humoral immunity and overexpression of caleticulin and Her-2/neu in tumor tissue were analyzed by immunohystochemistry. In 23 patients with metastases in regionally lymph nodes, seven had Her-2/neu overexpression. Among those seven patients, three developed distant metastasis (two women one year and in one woman two years after surgery) and all of them showed the presence of stromal IgG immunoreactivity and overexpression of calreticulin in their tumors tissue. Preliminary data showed that serum IgG immunoreactivity to tumor stroma in combination with overexpression of calreticulin in tumor cells correlate with postoperative appearance of metastases, particularly in the group of patients with Her-2/neu overexpressed tumors and metastases in axillary lymph nodes.
Literature
1.
Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO 2001 Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. Cancer Immun 1:4PubMed
2.
Hayashi E, Kuramitsu Y, Okada F, Fujimoto M, Zhang X, Kobayashi M, Iizuka N, Ueyama Y, Nakamura K 2005 Proteomic profiling for cancer progression: Differential display analysis for the expression of intracellular proteins between regressive and progressive cancer cell lines. Proteomics 5(4):1024–1032PubMedCrossRef
3.
Dissemond J, Busch M, Kothen T, Mors J, Weimann TK, Lindeke A, Goos M, Wagner SN 2004 Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma. Cancer Lett 203(2):225–231PubMedCrossRef
4.
Sipione S, Ewen C, Shostak I, Michalak M, Bleackley RC 2005 Impaired cytolytic activity in calreticulin-deficient CTLs. J Immunol 174(6):3212–3219PubMed
5.
Fraser SA, Karimi R, Michalak M, Hudig D 2000 Perforin lytic activity is controlled by calreticulin. J Immunol 164(8):4150–4155PubMed
6.
Colleoni M, Rotmensz N, Peruzzotti G, Maisonneuve P, Mazzarol G, Pruneri G 2005 Size of breast cancer metastases in axillary lymph nodes: clinical relevance of minimal lymph node involvement. J Clin Oncol 23(7):1379–1389PubMedCrossRef
7.
Ross JS, Fletcher JA 1998 The HER-2/neu Oncogene in breast cancer: Prognostic factor, predictive factor, and target for therapy. Oncologist 3(4):237–252PubMed
8.
Barbera-Guillem E, Nyhus JK, Wolford CC, Friece CR, Sampsel JW 2002 Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis and IgG immune complexes potentate the process. Cancer Res 62:7042–7049PubMed
9.
Shushakova N, Eden G, Dangers M, Zwirner J, Menne J, Gueler F, Luft FC, Haller H, Dumler I 2005 The urokinase/urokinase receptor system mediates the IgG immune complex-induced inflammation in lung. J Immunol 175(6):4060–4068PubMed
Metadata
Title
Effects of Humoral Immunity and Calreticulin Overexpression on Postoperative Course in Breast Cancer
Authors
Aleksandra Erić
Zorica Juranić
Zorka Milovanović
Ivan Marković
Momčilo Inić
Nevenka Stanojević-Bakić
Vesna Vojinović-Golubović
Publication date
01-03-2009
Publisher
Springer Netherlands
Published in
Pathology & Oncology Research / Issue 1/2009
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-008-9112-2

Other articles of this Issue 1/2009

Pathology & Oncology Research 1/2009 Go to the issue

Original Paper

Basal Phenotype in Breast Carcinoma Occurring in Women Aged 35 or Younger

Original Paper

Expression of Tight Junction Protein Claudin-4 in Basal-Like Breast Carcinomas

Original Paper

Investigation of Soluble HER2 and Transforming Growth Factor Beta-1 Serum Levels in Gestational Trophoblastic Disease

Letter

Calvarial Metastasis of a Renal Cell Carcinoma, Mimicking a Primary Alveolar Soft Part Sarcoma, in a Young Girl—a Rare Case Report

Original Paper

INCENP (Inner Centromere Protein) is Overexpressed in High Grade Non-Hodgkin B-cell Lymphomas

Original Paper

A Case of Osteoclast-like Giant Cell Tumor of the Pancreas Associated with Borderline Mucinous Cystic Neoplasm
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits