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International Journal of Hematology
Published in: International Journal of Hematology 4/2019

01-04-2019 | Methotrexate | Original Article

Optimal dosage of methotrexate for GVHD prophylaxis in umbilical cord blood transplantation

Authors: Yoshitaka Adachi, Kazutaka Ozeki, Shun Ukai, Ken Sagou, Nobuaki Fukushima, Akio Kohno

Published in: International Journal of Hematology | Issue 4/2019

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Abstract

The combination of methotrexate (MTX) and a calcineurin inhibitor is widely used for GVHD prophylaxis in umbilical cord blood transplantation (UCBT). However, the optimal MTX dosage for GVHD prophylaxis in UCBT remains unclear. In the present study, we investigated the impact of MTX dosage on clinical outcomes following UCBT in a single-center retrospective study. Of 70 UCBT recipients included in this study, 37 received MTX at doses of 10 mg/m2 on day 1, and 7 mg/m2 on days 3 and 6 (low-dose MTX: LD-MTX), and 33 received MTX at doses of 15 mg/m2 on day 1, and 10 mg/m2 on days 3 and 6 (standard-dose MTX: SD-MTX), in addition to tacrolimus (TAC). Grade 3–4 acute GVHD and/or transplant-related complications with endothelial cell damage were considered severe transplant-related complications. Univariate analysis findings revealed that the risk of grade 3–4 acute GVHD was significantly lower in the SD-MTX group than in the LD-MTX group (P = 0.013). Multivariate analysis findings revealed that SD-MTX was significantly associated with a lower incidence of severe transplant-related complications (HR = 0.25; 95% CI, 0.07–0.87; P = 0.029). We conclude that SD-MTX in combination with tacrolimus is optimal for GVHD prophylaxis in UCBT.
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Metadata
Title
Optimal dosage of methotrexate for GVHD prophylaxis in umbilical cord blood transplantation
Authors
Yoshitaka Adachi
Kazutaka Ozeki
Shun Ukai
Ken Sagou
Nobuaki Fukushima
Akio Kohno
Publication date
01-04-2019
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 4/2019
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-019-02598-x

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