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International Journal of Hematology
Published in: International Journal of Hematology 6/2013

01-06-2013 | Progress in Hematology

FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance

Authors: Michael R. Grunwald, Mark J. Levis

Published in: International Journal of Hematology | Issue 6/2013

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Abstract

Since the Food and Drug Administration approval of imatinib for treatment of chronic myeloid leukemia in 2001, tyrosine kinase inhibitors (TKIs) have become a mainstay in the care of many malignancies. In acute myeloid leukemia (AML), activating mutations in the FMS-like tyrosine kinase 3 (FLT3) gene result in survival and proliferation of leukemic blasts and are associated with adverse prognosis. Therefore, the FLT3 receptor is an appealing target for inhibition. Multiple small molecule TKIs are currently in development for FLT3-mutated AML, and agents are beginning to show promising efficacy. In other malignancies, the development of resistance to TKIs during the course of therapy has proven to be a challenge, and thus far, in clinical trials of FLT3 TKIs, resistance to inhibition represents a significant barrier to successful FLT3 inhibition. Understanding the mechanisms of resistance and overcoming these obstacles to target inhibition will be central to the success of these agents.
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Metadata
Title
FLT3 inhibitors for acute myeloid leukemia: a review of their efficacy and mechanisms of resistance
Authors
Michael R. Grunwald
Mark J. Levis
Publication date
01-06-2013
Publisher
Springer Japan
Published in
International Journal of Hematology / Issue 6/2013
Print ISSN: 0925-5710
Electronic ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-013-1334-8

Other articles of this Issue 6/2013

International Journal of Hematology 6/2013 Go to the issue

Original Article

Normal karyotype mosaicism in adult AML patients with adverse-risk and undefined karyotype: preliminary report of treatment outcomes after hematopoietic stem cell transplantation

Original Article

Genotypic and phenotypic features of Japanese patients with mild to moderate hemophilia A

Progress in Hematology

Sensitivity and resistance of JAK2 inhibitors to myeloproliferative neoplasms

Progress in Hematology

Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) in acute promyelocytic leukemia

Original Article

IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations

Progress in Hematology

Guest editorial: efficacy of and resistance to molecularly targeted therapy for myeloid malignancies
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