Published in:
01-10-2008 | Case Report
Aggressive CD5-positive B-cell lymphoma after remission of CD5-negative follicular lymphoma with distinct immunoglobulin heavy chain rearrangement and translocation
Authors:
Takashi Sonoki, Sonoko Ishihara, Shima Uneda, Nobuyoshi Hanaoka, Miwa Kurimoto, Hiroshi Matsuoka, Hideki Nakakuma
Published in:
International Journal of Hematology
|
Issue 3/2008
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Abstract
We report a unique, aggressive B-cell lymphoma that developed after the long-term remission of follicular lymphoma (FL). FL cells were negative for CD5, whereas aggressive lymphoma cells were positive for CD5. In FL, one immunoglobulin heavy chain gene (IGH) allele underwent V/D/J recombination and another t(14;18)(q32;q21). In aggressive lymphoma, one IGH allele underwent D/J recombination and another translocation, but not t(14;18)(q32;q21). An aggressive lymphoma-specific D/J sequence was detected in FL tissue. Our results indicated that the two tumors arose from distinct B cells and that they existed concurrently in the same lymph node.