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Published in: Annals of Behavioral Medicine 2/2012

Open Access 01-10-2012 | Original Article

A Randomized Controlled Trial of Qigong Exercise on Fatigue Symptoms, Functioning, and Telomerase Activity in Persons with Chronic Fatigue or Chronic Fatigue Syndrome

Authors: Rainbow T. H. Ho, Ph.D., Jessie S. M. Chan, M.P.H., Chong-Wen Wang, Ph.D., Benson W. M. Lau, Ph.D., Kwok Fai So, Ph.D., Li Ping Yuen, B.C.M., Jonathan S. T. Sham, M.D., Cecilia L. W. Chan, Ph.D.

Published in: Annals of Behavioral Medicine | Issue 2/2012

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Abstract

Background

Chronic fatigue is common in the general population. Complementary therapies are often used by patients with chronic fatigue or chronic fatigue syndrome to manage their symptoms.

Purpose

This study aimed to assess the effect of a 4-month qigong intervention program among patients with chronic fatigue or chronic fatigue syndrome.

Methods

Sixty-four participants were randomly assigned to either an intervention group or a wait list control group. Outcome measures included fatigue symptoms, physical functioning, mental functioning, and telomerase activity.

Results

Fatigue symptoms and mental functioning were significantly improved in the qigong group compared to controls. Telomerase activity increased in the qigong group from 0.102 to 0.178 arbitrary units (p < 0.05). The change was statistically significant when compared to the control group (p < 0.05).

Conclusion

Qigong exercise may be used as an alternative and complementary therapy or rehabilitative program for chronic fatigue and chronic fatigue syndrome.
Literature
1.
go back to reference Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: A comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994;121:953-959.PubMed Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: A comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994;121:953-959.PubMed
2.
go back to reference Carruthers BM, Jain AK, De Meirleir KL, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: Clinical working case definition, diagnostic and treatment protocols. J Chronic Fatigue Syndr. 2003;11:7-36.CrossRef Carruthers BM, Jain AK, De Meirleir KL, et al. Myalgic encephalomyelitis/chronic fatigue syndrome: Clinical working case definition, diagnostic and treatment protocols. J Chronic Fatigue Syndr. 2003;11:7-36.CrossRef
3.
go back to reference Wong WS, Fielding R. Prevalence of chronic fatigue among Chinese adults in Hong Kong: A population-based study. J Affect Disord. 2010;127:248-256.PubMedCrossRef Wong WS, Fielding R. Prevalence of chronic fatigue among Chinese adults in Hong Kong: A population-based study. J Affect Disord. 2010;127:248-256.PubMedCrossRef
4.
go back to reference Kim CH, Shin HC, Won CW. Prevalence of chronic fatigue and chronic fatigue syndrome in Korea: Community-based primary care study. J Korean Med Sci. 2005;20:529-534.PubMedCrossRef Kim CH, Shin HC, Won CW. Prevalence of chronic fatigue and chronic fatigue syndrome in Korea: Community-based primary care study. J Korean Med Sci. 2005;20:529-534.PubMedCrossRef
5.
go back to reference Evengard B, Jacks A, Pedersen NL, Sullivan PF. The epidemiology of chronic fatigue in the Swedish Twin Registry. Psychol Med. 2005;35:1317-1326.PubMedCrossRef Evengard B, Jacks A, Pedersen NL, Sullivan PF. The epidemiology of chronic fatigue in the Swedish Twin Registry. Psychol Med. 2005;35:1317-1326.PubMedCrossRef
6.
go back to reference Dinos S, Khoshaba B, Ashby D, et al. A systematic review of chronic fatigue, its syndromes and ethnicity: Prevalence, severity, co-morbidity and coping. Int J Epidemiol. 2009;38:1554-1570.PubMedCrossRef Dinos S, Khoshaba B, Ashby D, et al. A systematic review of chronic fatigue, its syndromes and ethnicity: Prevalence, severity, co-morbidity and coping. Int J Epidemiol. 2009;38:1554-1570.PubMedCrossRef
7.
go back to reference Nacul LC, Lacerda EM, Pheby D, et al. Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: A repeated cross-sectional study in primary care. BMC Med. 2011;9:91.PubMedCrossRef Nacul LC, Lacerda EM, Pheby D, et al. Prevalence of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in three regions of England: A repeated cross-sectional study in primary care. BMC Med. 2011;9:91.PubMedCrossRef
8.
go back to reference Cho HJ, Menezes PR, Hotopf M, Bhugra D, Wessely S. Comparative epidemiology of chronic fatigue syndrome in Brazilian and British primary care: Prevalence and recognition. Br J Psychiatry. 2009;194:117-122.PubMedCrossRef Cho HJ, Menezes PR, Hotopf M, Bhugra D, Wessely S. Comparative epidemiology of chronic fatigue syndrome in Brazilian and British primary care: Prevalence and recognition. Br J Psychiatry. 2009;194:117-122.PubMedCrossRef
9.
10.
go back to reference Lee S, Yu H, Wing Y, et al. Psychiatric morbidity and illness experience of primary care patients with chronic fatigue in Hong Kong. Am J Psychiatry. 2000;157:380-384.PubMedCrossRef Lee S, Yu H, Wing Y, et al. Psychiatric morbidity and illness experience of primary care patients with chronic fatigue in Hong Kong. Am J Psychiatry. 2000;157:380-384.PubMedCrossRef
11.
go back to reference Harvey SB, Wessely S. Chronic fatigue syndrome: Identifying zebras amongst the horses. BMC Med. 2009;7:58.PubMedCrossRef Harvey SB, Wessely S. Chronic fatigue syndrome: Identifying zebras amongst the horses. BMC Med. 2009;7:58.PubMedCrossRef
12.
go back to reference Vercoulen JH, Swanink CM, Galama JM, et al. The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: Development of a model. J Psychosom Res. 1998;45:507-517.PubMedCrossRef Vercoulen JH, Swanink CM, Galama JM, et al. The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: Development of a model. J Psychosom Res. 1998;45:507-517.PubMedCrossRef
13.
go back to reference Maes M, Twisk FN. Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Med. 2010;8:35.PubMedCrossRef Maes M, Twisk FN. Chronic fatigue syndrome: Harvey and Wessely's (bio)psychosocial model versus a bio(psychosocial) model based on inflammatory and oxidative and nitrosative stress pathways. BMC Med. 2010;8:35.PubMedCrossRef
14.
go back to reference Nater UM, Maloney E, Heim C, Reeves WC. Cumulative life stress in chronic fatigue syndrome. Psychiatry Res. 2011;189(2):318-320.PubMedCrossRef Nater UM, Maloney E, Heim C, Reeves WC. Cumulative life stress in chronic fatigue syndrome. Psychiatry Res. 2011;189(2):318-320.PubMedCrossRef
15.
go back to reference Van Houdenhove B, Luyten P, Egle UT. Stress as a key concept in chronic widespread pain and fatigue disorders. J Musculoskelet Pain. 2009;17:390-399.CrossRef Van Houdenhove B, Luyten P, Egle UT. Stress as a key concept in chronic widespread pain and fatigue disorders. J Musculoskelet Pain. 2009;17:390-399.CrossRef
16.
go back to reference Cleare AJ, Wessely SC. Chronic fatigue syndrome: A stress disorder? Br J Hosp Med. 1996;55:571-574.PubMed Cleare AJ, Wessely SC. Chronic fatigue syndrome: A stress disorder? Br J Hosp Med. 1996;55:571-574.PubMed
17.
go back to reference Masuda A, Munemoto T, Yamanaka T, Takei M, Tei C. Psychosocial characteristics and immunological functions in patients with postinfectious chronic fatigue syndrome and noninfectious chronic fatigue syndrome. J Behav Med. 2002;25:477-485.PubMedCrossRef Masuda A, Munemoto T, Yamanaka T, Takei M, Tei C. Psychosocial characteristics and immunological functions in patients with postinfectious chronic fatigue syndrome and noninfectious chronic fatigue syndrome. J Behav Med. 2002;25:477-485.PubMedCrossRef
18.
go back to reference Nater UM, Lin J-MS, Maloney EM, et al. Psychiatric comorbidity in persons with chronic fatigue syndrome identified from the Georgia population. Psychosom Med. 2009;71:557-565.PubMedCrossRef Nater UM, Lin J-MS, Maloney EM, et al. Psychiatric comorbidity in persons with chronic fatigue syndrome identified from the Georgia population. Psychosom Med. 2009;71:557-565.PubMedCrossRef
19.
go back to reference Faulkner S, Smith A. A longitudinal study of the relationship between psychological distress and recurrence of upper respiratory tract infections in chronic fatigue syndrome. Br J Health Psychol. 2008;13:177-186.PubMedCrossRef Faulkner S, Smith A. A longitudinal study of the relationship between psychological distress and recurrence of upper respiratory tract infections in chronic fatigue syndrome. Br J Health Psychol. 2008;13:177-186.PubMedCrossRef
20.
go back to reference Heim C, Wagner D, Maloney E, et al. Early adverse experience and risk for chronic fatigue syndrome: Results from a population-based study. Arch Gen Psychiatry. 2006;63:1258-1266.PubMedCrossRef Heim C, Wagner D, Maloney E, et al. Early adverse experience and risk for chronic fatigue syndrome: Results from a population-based study. Arch Gen Psychiatry. 2006;63:1258-1266.PubMedCrossRef
21.
go back to reference Huibers MJH, Beurskens AJHM, Van Schayck CP, et al. Efficacy of cognitive-behavioural therapy by general practitioners for unexplained fatigue among employees: Randomised controlled trial. Br J Psychiatry. 2004;184:240-246.PubMedCrossRef Huibers MJH, Beurskens AJHM, Van Schayck CP, et al. Efficacy of cognitive-behavioural therapy by general practitioners for unexplained fatigue among employees: Randomised controlled trial. Br J Psychiatry. 2004;184:240-246.PubMedCrossRef
22.
go back to reference Chen R, Moriya J, Yamakawa J, Takahashi T, Kanda T. Traditional Chinese medicine for chronic fatigue syndrome. Evid Based Complement Alternat Med. 2010;7:3-10.PubMedCrossRef Chen R, Moriya J, Yamakawa J, Takahashi T, Kanda T. Traditional Chinese medicine for chronic fatigue syndrome. Evid Based Complement Alternat Med. 2010;7:3-10.PubMedCrossRef
23.
go back to reference Afari N, Eisenberg DM, Herrell R, et al. Use of alternative treatments by chronic fatigue syndrome discordant twins. Integr Med. 2000;2:97-103.PubMedCrossRef Afari N, Eisenberg DM, Herrell R, et al. Use of alternative treatments by chronic fatigue syndrome discordant twins. Integr Med. 2000;2:97-103.PubMedCrossRef
24.
go back to reference Porter NS, Jason LA, Boulton A, Bothne N, Coleman B. Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. J Altern Complement Med. 2010;16:235-249.PubMedCrossRef Porter NS, Jason LA, Boulton A, Bothne N, Coleman B. Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. J Altern Complement Med. 2010;16:235-249.PubMedCrossRef
25.
go back to reference Adams D, Wu T, Yang X, Tai S, Vohra S. Traditional Chinese medicinal herbs for the treatment of idiopathic chronic fatigue and chronic fatigue syndrome. Cochrane Database Syst Rev. 2009;4:CD006348.PubMed Adams D, Wu T, Yang X, Tai S, Vohra S. Traditional Chinese medicinal herbs for the treatment of idiopathic chronic fatigue and chronic fatigue syndrome. Cochrane Database Syst Rev. 2009;4:CD006348.PubMed
26.
go back to reference Rendant D, Pach D, Ludtke R, et al. Qigong versus exercise versus no therapy for patients with chronic neck pain: A randomized controlled trial. Spine (Phila Pa 1976). 2011;36:419-427.CrossRef Rendant D, Pach D, Ludtke R, et al. Qigong versus exercise versus no therapy for patients with chronic neck pain: A randomized controlled trial. Spine (Phila Pa 1976). 2011;36:419-427.CrossRef
27.
go back to reference Lansinger B, Larsson E, Persson LC, Carlsson JY. Qigong and exercise therapy in patients with long-term neck pain: A prospective randomized trial. Spine (Phila Pa 1976). 2007;32:2415-2422.CrossRef Lansinger B, Larsson E, Persson LC, Carlsson JY. Qigong and exercise therapy in patients with long-term neck pain: A prospective randomized trial. Spine (Phila Pa 1976). 2007;32:2415-2422.CrossRef
28.
go back to reference Lee HJ, Park HJ, Chae Y, et al. Tai chi qigong for the quality of life of patients with knee osteoarthritis: A pilot, randomized, waiting list controlled trial. Clin Rehabil. 2009;23:504-511.PubMedCrossRef Lee HJ, Park HJ, Chae Y, et al. Tai chi qigong for the quality of life of patients with knee osteoarthritis: A pilot, randomized, waiting list controlled trial. Clin Rehabil. 2009;23:504-511.PubMedCrossRef
29.
go back to reference Haak T, Scott B. The effect of qigong on fibromyalgia (FMS): A controlled randomized study. Disabil Rehabil. 2008;30:625-633.PubMedCrossRef Haak T, Scott B. The effect of qigong on fibromyalgia (FMS): A controlled randomized study. Disabil Rehabil. 2008;30:625-633.PubMedCrossRef
30.
go back to reference Ng BH, Tsang HW, Jones AY, So CT, Mok TY. Functional and psychosocial effects of health qigong in patients with COPD: A randomized controlled trial. J Altern Complement Med. 2011;17:243-251.PubMedCrossRef Ng BH, Tsang HW, Jones AY, So CT, Mok TY. Functional and psychosocial effects of health qigong in patients with COPD: A randomized controlled trial. J Altern Complement Med. 2011;17:243-251.PubMedCrossRef
31.
go back to reference Oh B, Butow P, Mullan B, et al. Impact of medical qigong on quality of life, fatigue, mood and inflammation in cancer patients: A randomized controlled trial. Ann Oncol. 2010;21:608-614.PubMedCrossRef Oh B, Butow P, Mullan B, et al. Impact of medical qigong on quality of life, fatigue, mood and inflammation in cancer patients: A randomized controlled trial. Ann Oncol. 2010;21:608-614.PubMedCrossRef
32.
go back to reference Craske NJM, Turner W, Zammit-Maempe J, Lee MS. Qigong ameliorates symptoms of chronic fatigue: A pilot uncontrolled study. Evid Based Complement Alternat Med. 2009;6:265-270.PubMedCrossRef Craske NJM, Turner W, Zammit-Maempe J, Lee MS. Qigong ameliorates symptoms of chronic fatigue: A pilot uncontrolled study. Evid Based Complement Alternat Med. 2009;6:265-270.PubMedCrossRef
33.
go back to reference Dybwad MH, Frøslie KF, Stanghelle JK. Work capacity, fatigue and health related quality of life in patients with myalgic encephalopathy or chronic fatigue syndrome, before and after qigong therapy, a randomized controlled study. Nesoddtangen, Norway: Sunnaas Rehabilitation Hospital; 2007. Dybwad MH, Frøslie KF, Stanghelle JK. Work capacity, fatigue and health related quality of life in patients with myalgic encephalopathy or chronic fatigue syndrome, before and after qigong therapy, a randomized controlled study. Nesoddtangen, Norway: Sunnaas Rehabilitation Hospital; 2007.
35.
go back to reference Houben JM, Moonen HJ, van Schooten FJ, Hageman GJ. Telomere length assessment: Biomarker of chronic oxidative stress? Free Radic Biol Med. 2008;44:235-246.PubMedCrossRef Houben JM, Moonen HJ, van Schooten FJ, Hageman GJ. Telomere length assessment: Biomarker of chronic oxidative stress? Free Radic Biol Med. 2008;44:235-246.PubMedCrossRef
36.
go back to reference Epel ES. Telomeres in a life-span perspective: A new “psychobiomarker”? Curr Dir Psychol Sci. 2009;18:6-10.CrossRef Epel ES. Telomeres in a life-span perspective: A new “psychobiomarker”? Curr Dir Psychol Sci. 2009;18:6-10.CrossRef
38.
go back to reference Willeit P, Willeit J, Mayr A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA. 2010;304:69-75.PubMedCrossRef Willeit P, Willeit J, Mayr A, et al. Telomere length and risk of incident cancer and cancer mortality. JAMA. 2010;304:69-75.PubMedCrossRef
39.
go back to reference Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361:393-395.PubMedCrossRef Cawthon RM, Smith KR, O'Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet. 2003;361:393-395.PubMedCrossRef
40.
go back to reference Ornish D, Lin J, Daubenmier J, et al. Increased telomerase activity and comprehensive lifestyle changes: A pilot study. Lancet Oncol. 2008;9:1048-1057.PubMedCrossRef Ornish D, Lin J, Daubenmier J, et al. Increased telomerase activity and comprehensive lifestyle changes: A pilot study. Lancet Oncol. 2008;9:1048-1057.PubMedCrossRef
41.
go back to reference Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004;101:17312-17315.PubMedCrossRef Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A. 2004;101:17312-17315.PubMedCrossRef
42.
go back to reference Simon NM, Smoller JW, McNamara KL, et al. Telomere shortening and mood disorders: Preliminary support for a chronic stress model of accelerated aging. Biol Psychiatry. 2006;60:432-435.PubMedCrossRef Simon NM, Smoller JW, McNamara KL, et al. Telomere shortening and mood disorders: Preliminary support for a chronic stress model of accelerated aging. Biol Psychiatry. 2006;60:432-435.PubMedCrossRef
43.
go back to reference Kiecolt-Glaser JK, Glaser R. Psychological stress, telomeres, and telomerase. Brain Behav Immun. 2010;24:529-530.PubMedCrossRef Kiecolt-Glaser JK, Glaser R. Psychological stress, telomeres, and telomerase. Brain Behav Immun. 2010;24:529-530.PubMedCrossRef
44.
go back to reference Jacobs TL, Epel ES, Lin J, et al. Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology. 2011;36:664-681.PubMedCrossRef Jacobs TL, Epel ES, Lin J, et al. Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology. 2011;36:664-681.PubMedCrossRef
45.
go back to reference Lavretsky H, Epel ES, Siddarth P, et al. A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: Effects on mental health, cognition, and telomerase activity. Int J Geriatr Psychiatry. 2012 Mar 11. [Epub ahead of print]. Lavretsky H, Epel ES, Siddarth P, et al. A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: Effects on mental health, cognition, and telomerase activity. Int J Geriatr Psychiatry. 2012 Mar 11. [Epub ahead of print].
46.
go back to reference Werner C, Hanhoun M, Widmann T, et al. Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis. J Am Coll Cardiol. 2008;52:470-482.PubMedCrossRef Werner C, Hanhoun M, Widmann T, et al. Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis. J Am Coll Cardiol. 2008;52:470-482.PubMedCrossRef
47.
go back to reference Wolf SA, Melnik A, Kempermann G. Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia. Brain Behav Immun. 2011;25:971-980.PubMedCrossRef Wolf SA, Melnik A, Kempermann G. Physical exercise increases adult neurogenesis and telomerase activity, and improves behavioral deficits in a mouse model of schizophrenia. Brain Behav Immun. 2011;25:971-980.PubMedCrossRef
48.
go back to reference Deale A, Chalder T, Marks I, Wessely S. Cognitive behavior therapy for chronic fatigue syndrome: A randomized controlled trial. Am J Psychiatry. 1997;154:408-414.PubMed Deale A, Chalder T, Marks I, Wessely S. Cognitive behavior therapy for chronic fatigue syndrome: A randomized controlled trial. Am J Psychiatry. 1997;154:408-414.PubMed
49.
go back to reference Sharpe M, Hawton K, Simkin S, et al. Cognitive behaviour therapy for the chronic fatigue syndrome: A randomized controlled trial. BMJ. 1996;312:22-26.PubMedCrossRef Sharpe M, Hawton K, Simkin S, et al. Cognitive behaviour therapy for the chronic fatigue syndrome: A randomized controlled trial. BMJ. 1996;312:22-26.PubMedCrossRef
50.
go back to reference Chalder T, Berelowitz G, Pawlikowska T, et al. Development of a fatigue scale. J Psychosom Res. 1993;37:147-153.PubMedCrossRef Chalder T, Berelowitz G, Pawlikowska T, et al. Development of a fatigue scale. J Psychosom Res. 1993;37:147-153.PubMedCrossRef
51.
go back to reference Wong WS, Fielding R. Construct validity of the Chinese version of the Chalder Fatigue Scale in a Chinese community sample. J Psychosom Res. 2010;68:89-93.PubMedCrossRef Wong WS, Fielding R. Construct validity of the Chinese version of the Chalder Fatigue Scale in a Chinese community sample. J Psychosom Res. 2010;68:89-93.PubMedCrossRef
52.
go back to reference Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: Construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34:220-233.PubMedCrossRef Ware J Jr, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: Construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34:220-233.PubMedCrossRef
53.
go back to reference Lam CLK, Tse EYY, Gandek B. Is the standard SF-12 Health Survey valid and equivalent for a Chinese population? Qual Life Res. 2005;14:539-547.PubMedCrossRef Lam CLK, Tse EYY, Gandek B. Is the standard SF-12 Health Survey valid and equivalent for a Chinese population? Qual Life Res. 2005;14:539-547.PubMedCrossRef
54.
go back to reference Unnebrink K, Windeler J. Intention-to-treat: Methods for dealing with missing values in clinical trials of progressively deteriorating diseases. Stat Med. 2001;20:3931-3946.PubMedCrossRef Unnebrink K, Windeler J. Intention-to-treat: Methods for dealing with missing values in clinical trials of progressively deteriorating diseases. Stat Med. 2001;20:3931-3946.PubMedCrossRef
55.
go back to reference Wearden A, Appleby L. Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS). Psychol Med. 1997;27:81-90.PubMedCrossRef Wearden A, Appleby L. Cognitive performance and complaints of cognitive impairment in chronic fatigue syndrome (CFS). Psychol Med. 1997;27:81-90.PubMedCrossRef
56.
go back to reference Wolkowitz OM, Mellon SH, Epel ES, et al. Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response. Mol Psychiatry. 2012;17:164-172.PubMedCrossRef Wolkowitz OM, Mellon SH, Epel ES, et al. Resting leukocyte telomerase activity is elevated in major depression and predicts treatment response. Mol Psychiatry. 2012;17:164-172.PubMedCrossRef
57.
go back to reference Epel ES, Lin J, Dhabhar FS, et al. Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun. 2010;24:531-539.PubMedCrossRef Epel ES, Lin J, Dhabhar FS, et al. Dynamics of telomerase activity in response to acute psychological stress. Brain Behav Immun. 2010;24:531-539.PubMedCrossRef
58.
59.
go back to reference Binz N, Shalaby T, Rivera P, Shin-ya K, Grotzer MA. Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells. Eur J Cancer. 2005;41:2873-2881.PubMedCrossRef Binz N, Shalaby T, Rivera P, Shin-ya K, Grotzer MA. Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells. Eur J Cancer. 2005;41:2873-2881.PubMedCrossRef
60.
go back to reference Kennedy G, Spence VA, McLaren M, et al. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med. 2005;39:584-589.PubMedCrossRef Kennedy G, Spence VA, McLaren M, et al. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med. 2005;39:584-589.PubMedCrossRef
61.
go back to reference Van Houdenhove B, Van Den Eede F, Luyten P. Does hypothalamic–pituitary–adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system? Med Hypotheses. 2009;72:701-705.PubMedCrossRef Van Houdenhove B, Van Den Eede F, Luyten P. Does hypothalamic–pituitary–adrenal axis hypofunction in chronic fatigue syndrome reflect a 'crash' in the stress system? Med Hypotheses. 2009;72:701-705.PubMedCrossRef
62.
go back to reference Ludlow AT, Zimmerman JOB, Witkowski S, et al. Relationship between physical activity level, telomere length, and telomerase activity. Med Sci Sports Exerc. 2008;40:1764.PubMedCrossRef Ludlow AT, Zimmerman JOB, Witkowski S, et al. Relationship between physical activity level, telomere length, and telomerase activity. Med Sci Sports Exerc. 2008;40:1764.PubMedCrossRef
Metadata
Title
A Randomized Controlled Trial of Qigong Exercise on Fatigue Symptoms, Functioning, and Telomerase Activity in Persons with Chronic Fatigue or Chronic Fatigue Syndrome
Authors
Rainbow T. H. Ho, Ph.D.
Jessie S. M. Chan, M.P.H.
Chong-Wen Wang, Ph.D.
Benson W. M. Lau, Ph.D.
Kwok Fai So, Ph.D.
Li Ping Yuen, B.C.M.
Jonathan S. T. Sham, M.D.
Cecilia L. W. Chan, Ph.D.
Publication date
01-10-2012
Publisher
Springer-Verlag
Published in
Annals of Behavioral Medicine / Issue 2/2012
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-012-9381-6

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