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Annals of Behavioral Medicine
Published in: Annals of Behavioral Medicine 2/2011

01-04-2011 | Original Article

The Effect of Telephone-Administered Cognitive–Behavioral Therapy on Quality of Life among Patients with Multiple Sclerosis

Authors: David Cosio, Ph.D., Ling Jin, M.S, Juned Siddique, Dr.P.H., David C. Mohr, Ph.D.

Published in: Annals of Behavioral Medicine | Issue 2/2011

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Abstract

Background

Past research has found that a variety of physical, psychological, and social factors can affect quality of life (QOL). These previous findings suggest that interventions that address these factors could potentially improve QOL.

Purpose

The purpose of this study was to examine whether cognitive behavioral therapy (CBT) can improve QOL, and if so, explore which factors might mediate this effect.

Methods

This is a secondary analysis of a randomized controlled trial. One hundred twenty-seven participants with multiple sclerosis and depression were randomly assigned to either a telephone-administered CBT (T-CBT) or telephone-administered supportive emotion-focused therapy (T-SEFT) intervention.

Results

Patients assigned to T-CBT showed significantly greater improvements in QOL compared with those assigned to T-SEFT. The greater improvement in QOL among T-CBT recipients was mediated by improvements in depression and positive affect. There was also inconsistent support for the superior effect of CBT on QOL being mediated by improvement in fatigue.

Conclusions

T-CBT provided greater QOL benefits compared with T-SEFT, which controlled for non-specific treatment components. This study further suggests that T-CBT procedures specific to the management of depression and positive affect were uniquely useful in improving QOL.
Literature
1.
Noseworthy JH, Lucchinetti C, Rodriguez M, Weinshenker BG: Multiple sclerosis. New England Journal of Medicine. 2000, 343:938–952.PubMedCrossRef
2.
Benito-Leon J, Morales JM, Rivera-Navarro J, Mitchell A: A review about the impact of multiple sclerosis on health-related quality of life. Disability and Rehabilitation. 2003, 25:1291–1303.PubMedCrossRef
3.
Schwartz C, Frohner R: Contribution of demographic, medical, and social support variables in predicting the mental health dimension of quality of life among people with multiple sclerosis. Health and Social Work. 2005, 30:203–212.PubMed
4.
World Health Organization: The first ten years of the World Health Organization. Geneva, Switzerland: World Health Organization, 1958.
5.
Bol Y, Duits AA, Hupperts RM, Vlaeyen JW, Verhey FR: The psychology of fatigue in patients with multiple sclerosis: a review. Journal of Psychosomatic Research. 2009, 66:3–11.PubMedCrossRef
6.
Siegert RJ, Abernethy DA: Depression in multiple sclerosis: A review. Journal of Neurology, Neurosurgery & Psychiatry. 2005, 76:469–475.CrossRef
7.
Hart SL, Vella L, Mohr DC: Relationships among depressive symptoms, benefit-finding, optimism, and positive affect in multiple sclerosis patients after psychotherapy for depression. Health Psychology. 2008, 27:230–238.PubMedCrossRef
8.
Pakenham KI: Application of a stress and coping model to caregiving in multiple sclerosis. Psychology, Health, and Medicine. 2001, 6:13–27.CrossRef
9.
Mohr DC, Genain C: Social support as a buffer in the relationship between treatment for depression and T-cell production of interferon gamma in patients with multiple sclerosis. Journal of Psychosomatic Research. 2004, 57:155–158.PubMedCrossRef
10.
Janardhan V, Bakshi R: Quality of life in patients with multiple sclerosis: The impact of fatigue and depression. Journal of the Neurological Sciences. 2002, 205:51–58.PubMedCrossRef
11.
McCabe MP, Stokes M, McDonald E: Changes in quality of life and coping among people with multiple sclerosis over a 2 year period. Psychology, Health & Medicine. 2009, 14:86–96.CrossRef
12.
Foley FW, Bedell JR, LaRocca NG, Scheinberg LC, Reznikoff M: Efficacy of stress-innoculation training in coping with multiple sclerosis. Journal of Consulting and Clinical Psychology. 1987, 55:919–922.PubMedCrossRef
13.
Mohr DC, Boudewyn AC, Goodkin DE, Bostrom A, Epstein L: Comparative outcomes for individual cognitive-behavior therapy, supportive-expressive group psychotherapy, and sertraline for the treatment of depression in multiple sclerosis. Journal of Consulting and Clinical Psychology. 2001, 69:942–949.PubMedCrossRef
14.
Mohr DC, Likosky W, Bertagnolli A, et al.: Telephone-administered cognitive-behavioral therapy for the treatment of depressive symptoms in multiple sclerosis. Journal of Consulting and Clinical Psychology. 2000, 68:356–361.PubMedCrossRef
15.
Mohr DC, Hart SL, Julian L, et al.: Telephone-administered psychotherapy for depression. Archives of General Psychiatry. 2005, 62:1007–1014.PubMedCrossRef
16.
Mohr DC, Hart SL, Goldberg A: Effects of treatment for depression on fatigue in multiple sclerosis. Psychosomatic Medicine. 2003, 65:542–547.PubMedCrossRef
17.
Mohr DC, Hart S, Vella L: Reduction in disability in a randomized controlled trial of telephone-administered cognitive–behavioral therapy. Health Psychology. 2007, 26(5):554–563.PubMedCrossRef
18.
van Kessel K, Moss-Morris R, Willoughby E, et al.: A randomized controlled trial of cognitive behavior therapy for multiple sclerosis fatigue. Psychosomatic Medicine. 2008, 70:205–213.PubMedCrossRef
19.
Mohr DC, Classen C, Barrera M, Jr.: The relationship between social support, depression and treatment for depression in people with multiple sclerosis. Psychological Medicine. 2004, 34:533–541.PubMedCrossRef
20.
Tesar N, Baumhackl U, Kopp M, Gunther V: Effects of psychological group therapy in patients with multiple sclerosis. Acta Neurologica Scandinavica. 2003, 107:394–399.PubMedCrossRef
21.
Schwartz CE: Teaching coping skills enhances quality of life more than peer support: Results of a randomized trial with multiple sclerosis patients. Health Psychology. 1999, 18:211–220.PubMedCrossRef
22.
Hart S, Fonareva I, Merluzzi N, Mohr DC: Treatment for depression and its relationship to improvement in quality of life and psychological well-being in multiple sclerosis patients. Quality of Life Research. 2005, 14:695–703.PubMedCrossRef
23.
Sharrack B, Hughes RAC: The Guy's Neurological Disability Scale (GNDS): A new disability measure for multiple sclerosis. Multiple Sclerosis. 1999, 5:223–233.PubMed
24.
Beck AT, Steer RA, Brown GK: Beck Depression Inventory—second edition: Manual. San Antonio TX: Psychological Corporation, 1996.
25.
Hamilton M: The measurement of anxiety states by rating. British Journal of Medical Psychology. 1959, 32:56–62.
26.
Potts MK, Daniels M, Burnam MA, Wells KB: A structured interview version of the Hamilton Depression Rating Scale: Evidence of reliability and versatility of administration. Journal of Psychiatric Research. 1990, 24:335–350.PubMedCrossRef
27.
Mohr DC: The stress and mood management program for individuals with multiple sclerosis: Therapist guide. New York: Oxford Press, 2010.
28.
Mohr DC: The stress and mood management program for individuals with multiple sclerosis: Workbook. New York: Oxford Press, 2010.
29.
Multiple Sclerosis Council for Practice Guidelines: Fatigue and multiple sclerosis: Evidence-based management strategies for fatigue in multiple sclerosis. Washington D.C.: Paralyzed Veterans of America, 1998.
30.
Greenberg LS, Rice LN, Elliott R: Facilitating emotional change: The moment-by-moment process. New York: Guilford Press, 1993.
31.
Vallis TM, Shaw BF, Dobson KS: The cognitive therapy scale: psychometric properties. Journal of Consulting and Clinical Psychology. 1986, 54:381–385.PubMedCrossRef
32.
Vickrey BG, Hays RD, Harooni R, Myers LW, Ellison GW: A health-related quality of life measure for multiple sclerosis. Quality of Life Research. 1995, 4:187–206.PubMedCrossRef
33.
Crane HM, Van Rompaey SE, Dillingham PW, et al.: A single-item measure of health-related quality-of-life for HIV-infected patients in routine clinical care. Aids Patient Care and STDS. 2006, 20:161–174.PubMedCrossRef
34.
Fairclough D: Design and analysis of quality of life studies in clinical trials. Boca Raton, Florida: Chapman and Hall/CRC Press, 2002.
35.
Bernard J, Sullivan M, Hurny C, Coates AS, Rudenstam CM: Clinical relevance of single item quality of life indicators in cancer clinical trials. British Journal of Cancer. 2001, 84:1156–1165.
36.
Zimmerman M, Ruggero C, Chelminski I, et al.: Developing brief scales for use in clinical practice: The reliability and validity of single-item self-report measures of depression symptom severity, psychosocial impairment due to depression, and quality of life. Journal of Clinical Psychiatry. 2006, 67:1536–1541.
37.
Fisk JD, Pontefract A, Ritvo PG, Archibald CJ, Murray TJ: The impact of fatigue on patients with multiple sclerosis. Canadian Journal of Neurological Sciences. 1994, 21:9–14.PubMed
38.
Carver CS: You want to measure coping but your protocol's too long: Consider the Brief COPE. International Journal of Behavioral Medicine. 1997, 4:92–100.PubMedCrossRef
39.
Watson D: Intraindividual and interindividual analyses of positive and negative affect: Their relation to health complaints, perceived stress, and daily activities. Journal of Personality and Social Psychology. 1988, 54:1020–1030.PubMedCrossRef
40.
Schwarzer R, Dunkel-Schetter C, Kemeny M: The multidimensional nature of received social support in gay men at risk of HIV infection and AIDS. American Journal of Community Psychology. 1994, 22:319–339.PubMedCrossRef
41.
Gibbons RD, Hedeker D, Elkin I, et al.: Some conceptual and statistical issues in analysis of longitudinal psychiatric data. Application to the NIMH treatment of Depression Collaborative Research Program dataset. Archives of General Psychiatry. 1993, 50:739–750.PubMed
42.
Muller D, Judd CM, Yzerbyt VY: When moderation is mediated and mediation is moderated. Journal of Personality and Social Psychology. 2005, 89:852–863.PubMedCrossRef
43.
MacKinnon DP, Lockwood CM, Hoffman JM, West SG, Sheets V: A comparison of methods to test mediation and other intervening variable effects. Psychological Methods. 2002, 7:83–104.PubMedCrossRef
44.
Shrout PE, Bolger N: Mediation in experimental and nonexperimental studies: New procedures and recommendations. Psychological Methods. 2002, 7:422–445.PubMedCrossRef
45.
Sin NL, Lyubomirsky S: Enhancing well-being and alleviating depressive symptoms with positive psychology interventions: A practice-friendly meta-analysis. Journal of Clinical Psychology. 2009, 65:467–487.PubMedCrossRef
46.
Antoni MH, Lechner SC, Kazi A, et al.: How stress management improves quality of life after treatment for breast cancer. Journal of Consulting and Clinical Psychology. 2006, 74:1143–1152.PubMedCrossRef
47.
Grossman P, Tiefenthaler-Gilmer U, Raysz A, Kesper U: Mindfulness training as an intervention for fibromyalgia: Evidence of postintervention and 3-year follow-up benefits in well-being. Psychotherapy and Psychosomatics. 2007, 76:226–233.PubMedCrossRef
48.
Watson D, Naragon-Gainey K: On the specificity of positive emotional dysfunction in psychopathology: Evidence from the mood and anxiety disorders and schizophrenia/schizotypy. Clinical Psychology Review. 2009., 30: 839–848.
49.
Fredrickson BL: The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions. American Psychologist. 2001, 56:218–226.PubMedCrossRef
Metadata
Title
The Effect of Telephone-Administered Cognitive–Behavioral Therapy on Quality of Life among Patients with Multiple Sclerosis
Authors
David Cosio, Ph.D.
Ling Jin, M.S
Juned Siddique, Dr.P.H.
David C. Mohr, Ph.D.
Publication date
01-04-2011
Publisher
Springer-Verlag
Published in
Annals of Behavioral Medicine / Issue 2/2011
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-010-9236-y

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