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Open Access 01-11-2014 | Original Article

Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of ¹²³I-iodoamphetamine: comparison among data acquired at three institutions

Authors: Miho Yamauchi, Etsuko Imabayashi, Hiroshi Matsuda, Jyoji Nakagawara, Masaaki Takahashi, Eku Shimosegawa, Jun Hatazawa, Michiyasu Suzuki, Hideyuki Iwanaga, Kenji Fukuda, Koji Iihara, Hidehiro Iida

Published in: Annals of Nuclear Medicine | Issue 9/2014

Abstract

Purpose

A recently developed technique which reconstructs quantitative images from original projection data acquired using existing single-photon emission computed tomography (SPECT) devices enabled quantitative assessment of cerebral blood flow (CBF) at rest and after acetazolamide challenge. This study was intended to generate a normal database and to investigate its inter-institutional consistency.

Methods

The three institutions carried out a series of SPECT scanning on 32 healthy volunteers, following a recently proposed method that involved dual administration of ¹²³I-iodoamphetamine during a single SPECT scan. Intra-institute and inter-institutional variations of regional CBF values were evaluated both at rest and after acetazolamide challenge. Functional images were pooled for both rest and acetazolamide CBF, and inter-institutional difference was evaluated among these images using two independent software programs.

Results

Quantitative assessment of CBF images at rest and after acetazolamide was successfully achieved with the given protocol in all institutions. Intra-institutional variation of CBF values at rest and after acetazolamide was consistent with previously reported values. Quantitative CBF values showed no significant difference among institutions in all regions, except for a posterior cerebral artery region after acetazolamide challenge in one institution which employed SPECT device with lowest spatial resolution. Pooled CBF images at rest and after acetazolamide generated using two software programs showed no institutional differences after equalization of the spatial resolution.

Conclusions

SPECT can provide reproducible images from projection data acquired using different SPECT devices. A common database acquired at different institutions may be shared among institutions, if images are reconstructed using a quantitative reconstruction program, and acquired by following a standardized protocol.

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Title: Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of 123I-iodoamphetamine: comparison among data acquired at three institutions
Authors: Miho Yamauchi
Etsuko Imabayashi
Hiroshi Matsuda
Jyoji Nakagawara
Masaaki Takahashi
Eku Shimosegawa
Jun Hatazawa
Michiyasu Suzuki
Hideyuki Iwanaga
Kenji Fukuda
Koji Iihara
Hidehiro Iida
Publication date: 01-11-2014
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 9/2014
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-014-0879-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Quantitative assessment of rest and acetazolamide CBF using quantitative SPECT reconstruction and sequential administration of ¹²³I-iodoamphetamine: comparison among data acquired at three institutions

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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