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01-06-2012 | Original article

SISCOM technique with a variable Z score improves detectability of focal cortical dysplasia: a comparative study with MRI

Authors: Yukio Kimura, Noriko Sato, Kimiteru Ito, Kouhei Kamiya, Yasuhiro Nakata, Yuko Saito, Hiroshi Matsuda, Kenji Sugai, Masayuki Sasaki, Hideharu Sugimoto

Published in: Annals of Nuclear Medicine | Issue 5/2012

Abstract

Objective

Focal cortical dysplasia (FCD) is one of the causes of epilepsy, but its diagnosis by MRI remains difficult. The purpose of this study was to evaluate the use of subtraction ictal SPECT coregistered to MRI (SISCOM) and MRI to detect the epileptogenic focus in patients with FCD.

Methods

MRI and SISCOM findings of 20 patients with pathologically proven FCD were retrospectively reviewed. MRI was visually assessed for detecting FCD. SISCOM was evaluated by a new method selecting a higher standard deviation (Z score) area as the epileptogenic focus. We scored the detectability in both SISCOM and MRI while referring to the pathology.

Results

Sixteen patients agreed with pathology on SISCOM and 14 patients on MRI. Although MRI could not point out foci in two cases of FCD type I, SISCOM could do so in both of them. A combined diagnosis of SISCOM and MRI agreed with the pathology in 18 patients.

Conclusions

Narrowing the target by elevating the Z score on SISCOM seems to be an appropriate method to detect the foci without the need for expertise of radiologists. We recommend this combined method of SISCOM and MRI for presurgical evaluation in patients with FCD.

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Title: SISCOM technique with a variable Z score improves detectability of focal cortical dysplasia: a comparative study with MRI
Authors: Yukio Kimura
Noriko Sato
Kimiteru Ito
Kouhei Kamiya
Yasuhiro Nakata
Yuko Saito
Hiroshi Matsuda
Kenji Sugai
Masayuki Sasaki
Hideharu Sugimoto
Publication date: 01-06-2012
Publisher: Springer Japan
Published in: Annals of Nuclear Medicine / Issue 5/2012
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-012-0585-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

SISCOM technique with a variable Z score improves detectability of focal cortical dysplasia: a comparative study with MRI

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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