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Head and Neck Pathology
Published in: Head and Neck Pathology 3/2022

29-03-2022 | Ameloblastoma | Original Paper

Expression of a Tumor Stem Cell Marker (Aldehyde Dehydrogenase 1-ALDH1) in Benign Epithelial Odontogenic Lesions

Authors: Gustavo Alcântara da Trindade, Leorik Pereira da Silva, Pedro Paulo de Andrade Santos, Leão Pereira Pinto, Lélia Batista de Souza

Published in: Head and Neck Pathology | Issue 3/2022

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Abstract

The morphological diversity and different biological behaviors of human lesions has been attributed to the presence of cells with stem cell (SC) characteristics. Among SC markers, ALDH1 has been used in studies investigating different neoplasms and high expression of this marker was associated with clinicopathological features and prognosis in some groups. The aim of this study was to analyze the presence and distribution of SCs based on the expression of ALDH1 in epithelial odontogenic cysts and tumors. The sample consisted of 80 cases (20 dentigerous cysts (DCs), 20 odontogenic keratocysts (OKCs), 20 ameloblastomas (AMs), and 20 adenomatoid odontogenic tumors (AOTs). An immunoreactivity score was obtained from the percentage of positive cells and intensity of immunostaining. A level of 5% (p < 0.05) was adopted for the statistical tests. Immunoexpression of ALDH1 was observed in cytoplasm and nucleus-cytoplasm. The median scores indicated significantly higher expression in OKCs and DCs compared to AMs (p < 0.0001) and AOTs (p < 0.0001). In the tumor stroma and cystic capsule, immunoreactivity was detected in all odontogenic cysts studied and in 85% and 90% of AMs and AOTs, respectively. The expression of ALDH1 suggests the presence of SCs in the odontogenic lesions studied. Epithelial immunoexpression was higher in odontogenic cysts than in odontogenic tumors.
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Metadata
Title
Expression of a Tumor Stem Cell Marker (Aldehyde Dehydrogenase 1-ALDH1) in Benign Epithelial Odontogenic Lesions
Authors
Gustavo Alcântara da Trindade
Leorik Pereira da Silva
Pedro Paulo de Andrade Santos
Leão Pereira Pinto
Lélia Batista de Souza
Publication date
29-03-2022
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 3/2022
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-022-01430-z

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