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Head and Neck Pathology
Published in: Head and Neck Pathology 1/2020

01-03-2020 | Sine qua non Clinicopathologic Correlation

Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation

Author: Fredrik Petersson

Published in: Head and Neck Pathology | Issue 1/2020

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Abstract

A case of non-keratinizing, EBV-positive (EBER-in situ hybridization), carcinoma with adenomatous differentiation is presented. The patient is a 40 year old male with T2N2M0 disease who received standard combined chemo- and radiotherapy with complete resolution of all tumor. The tumor cells were strongly positive for low-molecular weight cytokeratins (AE1–3) and scattered cells expressed cytokeratin 20. No expression of cytokeratin 5/6, 7, p63, TTF-1, CDX2 or androgen receptor was detected. There was no evidence of recurrence or disease progression on follow-up after 19 months, which included post treatment MRI and PET–CT scans.
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Metadata
Title
Non-Keratinizing Nasopharyngeal Carcinoma with Adenomatous Differentiation
Author
Fredrik Petersson
Publication date
01-03-2020
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 1/2020
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-018-0991-6

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