Skip to main content
Top
Published in: Head and Neck Pathology 2/2019

01-06-2019 | Original Paper

Primordial Odontogenic Tumor: Report of a New Case and Literature Review

Authors: Bianca Bravim Bomfim, Roberto Prado, Renato Kobler Sampaio, Danielle Castex Conde, Bruno Augusto Benevenuto de Andrade, Michelle Agostini, Mário José Romañach

Published in: Head and Neck Pathology | Issue 2/2019

Login to get access

Abstract

Primordial odontogenic tumor (POT) was recently recognized in the 2017 World Health Organization (WHO) Classification as a distinct mixed odontogenic tumor most commonly observed in the posterior mandible of young patients. POT appears as an expansile radiolucency associated to an unerupted tooth. The aim of the present study was to perform a retrospective microscopic evaluation of pediatric odontogenic tumors diagnosed in an Oral Pathology Laboratory from Rio de Janeiro—Brazil, in order to reclassify potential cases as POT. From 150 cases of odontogenic tumors in children diagnosed in the last 50 years, one case filled the criteria for POT, being therefore better diagnosed as such. The patient was in the first decade of life and presented a well-defined expansile tumor in the posterior mandible, which had been initially diagnosed as immature complex odontoma. To the best of our knowledge, only 12 cases of POT have been reported in the English-language literature. We herein present an additional case of POT and review of its clinicopathological findings is offered.
Literature
1.
go back to reference Mosqueda-Taylor A, Neville BW. Primordial odontogenic tumour. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. World Health Organization Classification of Head and Neck Tumours. IARC: Lyon; 2017. pp. 223–4. Mosqueda-Taylor A, Neville BW. Primordial odontogenic tumour. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, editors. World Health Organization Classification of Head and Neck Tumours. IARC: Lyon; 2017. pp. 223–4.
2.
go back to reference Mosqueda-Taylor A, Pires FR, Aguirre-Urízar JM, et al. Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity. Histopathology. 2014;65:606–12.CrossRefPubMed Mosqueda-Taylor A, Pires FR, Aguirre-Urízar JM, et al. Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity. Histopathology. 2014;65:606–12.CrossRefPubMed
3.
go back to reference Wright JM, Vered M. Update from the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11:68–77.CrossRefPubMedPubMedCentral Wright JM, Vered M. Update from the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumors. Head Neck Pathol. 2017;11:68–77.CrossRefPubMedPubMedCentral
5.
6.
go back to reference Woo SB. Primordial odontogenic tumor. In: Woo SB, editor. Oral pathology: a comprehensive atlas and text. 2nd ed. Elsevier; 2017. p. 416. Woo SB. Primordial odontogenic tumor. In: Woo SB, editor. Oral pathology: a comprehensive atlas and text. 2nd ed. Elsevier; 2017. p. 416.
7.
go back to reference Bomfim BB, Prado R, Conde DC, Sampaio RK, Romañach MJ. Immature complex odontoma: report of a case with features of ameloblastic fibroma with induction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:e164.CrossRef Bomfim BB, Prado R, Conde DC, Sampaio RK, Romañach MJ. Immature complex odontoma: report of a case with features of ameloblastic fibroma with induction. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:e164.CrossRef
8.
go back to reference Slater LJ, Eftimie LF, Herford AS. Primordial odontogenic tumor: report of a case. J Oral Maxillofac Surg. 2016;74:547–51.CrossRefPubMed Slater LJ, Eftimie LF, Herford AS. Primordial odontogenic tumor: report of a case. J Oral Maxillofac Surg. 2016;74:547–51.CrossRefPubMed
9.
go back to reference Ando T, Shrestha M, Nakamoto T, Uchisako K, Yamasaki S, Koizumi K, Ogawa I, Miyauchi M, Takata T. A case of primordial odontogenic tumor: a new entity in the latest WHO classification (2017). Pathol Int. 2017;67:365–9.CrossRefPubMed Ando T, Shrestha M, Nakamoto T, Uchisako K, Yamasaki S, Koizumi K, Ogawa I, Miyauchi M, Takata T. A case of primordial odontogenic tumor: a new entity in the latest WHO classification (2017). Pathol Int. 2017;67:365–9.CrossRefPubMed
10.
go back to reference Mikami T, Ohashi Y, Bologna-Molina R, Mosqueda-Taylor A, Fujiwara N, Tsunoda N, Yamada H, Takeda Y. Primordial odontogenic tumor: a case report with histopathological analyses. Pathol Int. 2017;12:638–43.CrossRef Mikami T, Ohashi Y, Bologna-Molina R, Mosqueda-Taylor A, Fujiwara N, Tsunoda N, Yamada H, Takeda Y. Primordial odontogenic tumor: a case report with histopathological analyses. Pathol Int. 2017;12:638–43.CrossRef
11.
go back to reference Pardhe N, Bajpai M. Primordial odontogenic tumor of mandible: a case with proposed diagnostic criteria. Iran J Med Sci. 2018;43:97–9.PubMedPubMedCentral Pardhe N, Bajpai M. Primordial odontogenic tumor of mandible: a case with proposed diagnostic criteria. Iran J Med Sci. 2018;43:97–9.PubMedPubMedCentral
13.
go back to reference Bologna-Molina R, Mikami T, Pereira-Prado V, Pires FR, Carlos-Bregni R, Mosqueda-Taylor A. Primordial odontogenic tumor: an immunohistochemical profile. Med Oral Patol Oral Cir Bucal. 2017;22:e314–23.PubMedPubMedCentral Bologna-Molina R, Mikami T, Pereira-Prado V, Pires FR, Carlos-Bregni R, Mosqueda-Taylor A. Primordial odontogenic tumor: an immunohistochemical profile. Med Oral Patol Oral Cir Bucal. 2017;22:e314–23.PubMedPubMedCentral
14.
go back to reference Bologna-Molina R, Mikami T, Pereira-Prado V, Tapia-Repetto G, Pires FR, Carlos R, Mosqueda-Taylor A. Primordial odontogenic tumor: subepithelial expression of Syndecan-1 and Ki-67 suggests origin during early odontogenesis. Oral Dis. 2018;24:72–7.CrossRefPubMed Bologna-Molina R, Mikami T, Pereira-Prado V, Tapia-Repetto G, Pires FR, Carlos R, Mosqueda-Taylor A. Primordial odontogenic tumor: subepithelial expression of Syndecan-1 and Ki-67 suggests origin during early odontogenesis. Oral Dis. 2018;24:72–7.CrossRefPubMed
15.
go back to reference Ide F, Kikuchi K, Kusama K, Muramatsu T. Primordial odontogenic tumour: is it truly novel? Histopathology. 2015;66:603–4.CrossRefPubMed Ide F, Kikuchi K, Kusama K, Muramatsu T. Primordial odontogenic tumour: is it truly novel? Histopathology. 2015;66:603–4.CrossRefPubMed
Metadata
Title
Primordial Odontogenic Tumor: Report of a New Case and Literature Review
Authors
Bianca Bravim Bomfim
Roberto Prado
Renato Kobler Sampaio
Danielle Castex Conde
Bruno Augusto Benevenuto de Andrade
Michelle Agostini
Mário José Romañach
Publication date
01-06-2019
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 2/2019
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-018-0913-7

Other articles of this Issue 2/2019

Head and Neck Pathology 2/2019 Go to the issue

Sine qua non Radiology-Pathology

Seromucinous Hamartoma of the Nasal Cavity