Skip to main content
Top
Published in: Head and Neck Pathology 4/2017

01-12-2017 | Original Paper

Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature

Authors: Rana Alshagroud, Amandip Kamoh, Saurin R. Popat, Margaret Brandwein-Weber, Alfredo Aguirre

Published in: Head and Neck Pathology | Issue 4/2017

Login to get access

Abstract

Pleomorphic adenoma (PA) is by far the most common salivary gland tumor. It is well known that PA can undergo malignant transformation. However, in rare occasions it can metastasize preserving its benign phenotype. Metastasizing pleomorphic adenoma (MPA) constitutes an extremely rare tumor. Here we are reporting an unusual MPA affecting the mandible that was preceded by a submandibular gland pleomorphic adenoma.
Literature
1.
go back to reference Ellis GL, Auclair PL. Tumors of the Salivary Glands. AFIP Atlas of Tumor Pathology. Series 4. Washington: ARP PRESS; 2008. P. 27,372. Ellis GL, Auclair PL. Tumors of the Salivary Glands. AFIP Atlas of Tumor Pathology. Series 4. Washington: ARP PRESS; 2008. P. 27,372.
3.
go back to reference Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, et al. Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer. 2006;47(6):806–10. doi:10.1002/pbc.20637.CrossRefPubMed Guzzo M, Ferrari A, Marcon I, Collini P, Gandola L, Pizzi N, et al. Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer. 2006;47(6):806–10. doi:10.​1002/​pbc.​20637.CrossRefPubMed
4.
go back to reference Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg. 1986;8(3):177–84.CrossRefPubMed Spiro RH. Salivary neoplasms: overview of a 35-year experience with 2,807 patients. Head Neck Surg. 1986;8(3):177–84.CrossRefPubMed
5.
go back to reference Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, et al. Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature. Eur Arch Otorhinolaryngol. 2011;268(7):1035–40. doi:10.1007/s00405-010-1437-2.CrossRefPubMed Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, et al. Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature. Eur Arch Otorhinolaryngol. 2011;268(7):1035–40. doi:10.​1007/​s00405-010-1437-2.CrossRefPubMed
6.
go back to reference Gnepp DR, Henley JD, Simpson RHW and Eveson J. Pleomorphic adenoma (Benign mixed tumor). In: Gnepp DR editor. Diagnostic Surgical Pathology of the Head and Neck, 2nd edn. Philadelphia: Saunders (Elseviere); 2009. p. 438–449. Gnepp DR, Henley JD, Simpson RHW and Eveson J. Pleomorphic adenoma (Benign mixed tumor). In: Gnepp DR editor. Diagnostic Surgical Pathology of the Head and Neck, 2nd edn. Philadelphia: Saunders (Elseviere); 2009. p. 438–449.
9.
go back to reference Friedrich RE, Li L, Knop J, Giese M, Schmelzle R. Pleomorphic adenoma of the salivary glands: analysis of 94 patients. Anticancer Res. 2005;25(3A):1703–5.PubMed Friedrich RE, Li L, Knop J, Giese M, Schmelzle R. Pleomorphic adenoma of the salivary glands: analysis of 94 patients. Anticancer Res. 2005;25(3A):1703–5.PubMed
11.
go back to reference Bouquot JE, Gnepp DR, Dardick I, Hietanen JH. Intraosseous salivary tissue: jawbone examples of choristomas, hamartomas, embryonic rests, and inflammatory entrapment: another histogenetic source for intraosseous adenocarcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90(2):205–17.CrossRefPubMed Bouquot JE, Gnepp DR, Dardick I, Hietanen JH. Intraosseous salivary tissue: jawbone examples of choristomas, hamartomas, embryonic rests, and inflammatory entrapment: another histogenetic source for intraosseous adenocarcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90(2):205–17.CrossRefPubMed
12.
go back to reference Batsakis JG. Tumors of the head and neck: clinical and pathological considerations. 2nd ed. Baltimore. Williams & Wilkins; 1979. p. 97. Batsakis JG. Tumors of the head and neck: clinical and pathological considerations. 2nd ed. Baltimore. Williams & Wilkins; 1979. p. 97.
14.
go back to reference Rosenthal W. Beitrag zur vViederherstellungschirurgie nach kieferresektion und Nekrose. Arch Klin Chir. 1927;141:248. Rosenthal W. Beitrag zur vViederherstellungschirurgie nach kieferresektion und Nekrose. Arch Klin Chir. 1927;141:248.
15.
go back to reference Hoffer O, Vogel G. Mixed tumor of the salivary glands of the mandible. Report of a case. Oral Surg Oral Med Oral Pathol. 1960;13:519–22.CrossRefPubMed Hoffer O, Vogel G. Mixed tumor of the salivary glands of the mandible. Report of a case. Oral Surg Oral Med Oral Pathol. 1960;13:519–22.CrossRefPubMed
16.
go back to reference Miller AS, Winnick M. Salivary gland inclusion in the anterior mandible. Report of a case with a review of the literature on aberrant salivary gland tissue and neoplasms. Oral Surg Oral Med Oral Pathol. 1971;31(6):790–7.CrossRefPubMed Miller AS, Winnick M. Salivary gland inclusion in the anterior mandible. Report of a case with a review of the literature on aberrant salivary gland tissue and neoplasms. Oral Surg Oral Med Oral Pathol. 1971;31(6):790–7.CrossRefPubMed
17.
go back to reference Breitenecker G, Wepner F. A pleomorphic adenoma (so-called mixed tumor) in the wall of a dentigerous cyst. Oral Surg Oral Med Oral Pathol. 1973;36(1):63–71.CrossRefPubMed Breitenecker G, Wepner F. A pleomorphic adenoma (so-called mixed tumor) in the wall of a dentigerous cyst. Oral Surg Oral Med Oral Pathol. 1973;36(1):63–71.CrossRefPubMed
18.
go back to reference Sadeghi EM, Darling JE. Cystic pleomorphic adenoma of the mandible. Int J Oral Maxillofac Surg. 1994;23(2):93–5.CrossRefPubMed Sadeghi EM, Darling JE. Cystic pleomorphic adenoma of the mandible. Int J Oral Maxillofac Surg. 1994;23(2):93–5.CrossRefPubMed
20.
go back to reference Brookstone MS, Huvos AG. Central salivary gland tumors of the maxilla and mandible: a clinicopathologic study of 11 cases with an analysis of the literature. J Oral Maxillofac Surg. 1992;50(3):229–36.CrossRefPubMed Brookstone MS, Huvos AG. Central salivary gland tumors of the maxilla and mandible: a clinicopathologic study of 11 cases with an analysis of the literature. J Oral Maxillofac Surg. 1992;50(3):229–36.CrossRefPubMed
21.
go back to reference Ferretti C, Coleman H, Altini M, Meer S. Intraosseous myoepithelial neoplasms of the maxilla: diagnostic and therapeutic considerations in 5 South African patients. J Oral Maxillofac Surg. 2003;61(3):379–86. doi:10.1053/joms.2003.50075.CrossRefPubMed Ferretti C, Coleman H, Altini M, Meer S. Intraosseous myoepithelial neoplasms of the maxilla: diagnostic and therapeutic considerations in 5 South African patients. J Oral Maxillofac Surg. 2003;61(3):379–86. doi:10.​1053/​joms.​2003.​50075.CrossRefPubMed
22.
go back to reference Aver-De-Araujo LM, Chaves-Tarquinio SB, Neuzling-Gomes AP, Etges A. Intraosseous pleomorphic adenoma: case report and review of the literature. Med Oral. 2002;7(3):164–70.PubMed Aver-De-Araujo LM, Chaves-Tarquinio SB, Neuzling-Gomes AP, Etges A. Intraosseous pleomorphic adenoma: case report and review of the literature. Med Oral. 2002;7(3):164–70.PubMed
23.
go back to reference Bradley PJ. ‘Metastasizing pleomorphic salivary adenoma’ should now be considered a low-grade malignancy with a lethal potential. Curr Opin Otolaryngol Head Neck Surg. 2005;13(2):123–6.CrossRefPubMed Bradley PJ. ‘Metastasizing pleomorphic salivary adenoma’ should now be considered a low-grade malignancy with a lethal potential. Curr Opin Otolaryngol Head Neck Surg. 2005;13(2):123–6.CrossRefPubMed
24.
go back to reference Wenig BM, Hitchcock CL, Ellis GL, Gnepp DR. Metastasizing mixed tumor of salivary glands. A clinicopathologic and flow cytometric analysis. Am J Surg Pathol. 1992;16(9):845–58.CrossRefPubMed Wenig BM, Hitchcock CL, Ellis GL, Gnepp DR. Metastasizing mixed tumor of salivary glands. A clinicopathologic and flow cytometric analysis. Am J Surg Pathol. 1992;16(9):845–58.CrossRefPubMed
25.
go back to reference Gnepp DR. Metastasizing pleomorphic adenoma. In: Barnes L, Eveson J, Reichart P, Sidransky D, editors. World Health Oraganization Classification of Tumors: Pathology and Genetics of Head and Neck Tumors. Lyon: IARC Press; 2005. p. 245. Gnepp DR. Metastasizing pleomorphic adenoma. In: Barnes L, Eveson J, Reichart P, Sidransky D, editors. World Health Oraganization Classification of Tumors: Pathology and Genetics of Head and Neck Tumors. Lyon: IARC Press; 2005. p. 245.
26.
go back to reference El-Naggar AK. WHO classification of tumours of the salivary glands. In: El-Naggar AK, Chan JC, Grandis JR, Takata T, Slootweg P, editors. World Health Organization Classification of Tumors: Pathology and Genetics of Head and Neck Tumors. Lyon: IARC Press; 2017. p. 162. El-Naggar AK. WHO classification of tumours of the salivary glands. In: El-Naggar AK, Chan JC, Grandis JR, Takata T, Slootweg P, editors. World Health Organization Classification of Tumors: Pathology and Genetics of Head and Neck Tumors. Lyon: IARC Press; 2017. p. 162.
29.
32.
go back to reference Young VS, Viktil E, Loberg EM, Enden T. Benign metastasizing pleomorphic adenoma in liver mimicking synchronic metastatic disease from colorectal cancer: a case report with emphasis on imaging findings. Acta Radiol Open. 2015;4(8):1–5. doi:10.1177/2058460115594199. Young VS, Viktil E, Loberg EM, Enden T. Benign metastasizing pleomorphic adenoma in liver mimicking synchronic metastatic disease from colorectal cancer: a case report with emphasis on imaging findings. Acta Radiol Open. 2015;4(8):1–5. doi:10.​1177/​2058460115594199​.
34.
35.
go back to reference Wajed MA, Cardoe N, Gleave JR. Spinal cord compression due to metastasis from a mixed salivary gland tumour. Clin Oncol. 1978;4(3):295–8.PubMed Wajed MA, Cardoe N, Gleave JR. Spinal cord compression due to metastasis from a mixed salivary gland tumour. Clin Oncol. 1978;4(3):295–8.PubMed
36.
go back to reference Hyun-Hee Y, Cho C-W, Jeon M-Y, Kim D-J. Craniospinal metastasis from a metastasizing mixed tumor of salivary gland: unusual presentation. J Korean Neurosurg Soc. 2007;41:186–9.CrossRef Hyun-Hee Y, Cho C-W, Jeon M-Y, Kim D-J. Craniospinal metastasis from a metastasizing mixed tumor of salivary gland: unusual presentation. J Korean Neurosurg Soc. 2007;41:186–9.CrossRef
37.
go back to reference Yamaguchi T, Ashizawa K, Nagaoki K, Abiru H, Uetani M, Tagawa T, Nagayasu T, Hayashi T. Metastasizing pleomorphic adenoma of the submandibular gland with metastasis to the lung and sternum: CT and MR imaging findings. Eur J Radiol Extra. 2009;72:69–72.CrossRef Yamaguchi T, Ashizawa K, Nagaoki K, Abiru H, Uetani M, Tagawa T, Nagayasu T, Hayashi T. Metastasizing pleomorphic adenoma of the submandibular gland with metastasis to the lung and sternum: CT and MR imaging findings. Eur J Radiol Extra. 2009;72:69–72.CrossRef
38.
go back to reference Larbcharoensub N, Cert PK, Tungkeeratichai J, Prakunhungsit S, Narkwong L, Leopairut J. Expression of hormonal receptor in patients with metastasizing pleomorphic adenoma of the major salivary gland; a clinicopathological report of three cases. J Med Assoc Thai. 2009;92(9):1250–5.PubMed Larbcharoensub N, Cert PK, Tungkeeratichai J, Prakunhungsit S, Narkwong L, Leopairut J. Expression of hormonal receptor in patients with metastasizing pleomorphic adenoma of the major salivary gland; a clinicopathological report of three cases. J Med Assoc Thai. 2009;92(9):1250–5.PubMed
39.
go back to reference Drinkard DW, Schow CE Jr. Benign mixed tumor of the mandible 17 years after the occurrence of a similar lesion in the parotid gland. Oral Surg Oral Med Oral Pathol. 1986;62(4):381–4.CrossRefPubMed Drinkard DW, Schow CE Jr. Benign mixed tumor of the mandible 17 years after the occurrence of a similar lesion in the parotid gland. Oral Surg Oral Med Oral Pathol. 1986;62(4):381–4.CrossRefPubMed
40.
go back to reference Jin Y, Jin C, Arheden K, Larsson O, Bauer HF, Mandahl N, et al. Unbalanced chromosomal rearrangements in a metastasizing salivary gland tumor with benign histology. Cancer Genet Cytogenet. 1998;102(1):59–64.CrossRefPubMed Jin Y, Jin C, Arheden K, Larsson O, Bauer HF, Mandahl N, et al. Unbalanced chromosomal rearrangements in a metastasizing salivary gland tumor with benign histology. Cancer Genet Cytogenet. 1998;102(1):59–64.CrossRefPubMed
42.
go back to reference Akiba J, Harada H, Kawahara A, Todoroki K, Nagata S, Yano H. A case of metastasizing pleomorphic adenoma in the maxillary bone appearing twenty years after initial resection of pleomorphic adenoma of the hard palate. Pathol Int. 2013;63(9):463–8. doi:10.1111/pin.12087.PubMed Akiba J, Harada H, Kawahara A, Todoroki K, Nagata S, Yano H. A case of metastasizing pleomorphic adenoma in the maxillary bone appearing twenty years after initial resection of pleomorphic adenoma of the hard palate. Pathol Int. 2013;63(9):463–8. doi:10.​1111/​pin.​12087.PubMed
Metadata
Title
Metastasizing Pleomorphic Adenoma Case Report and Review of the Literature
Authors
Rana Alshagroud
Amandip Kamoh
Saurin R. Popat
Margaret Brandwein-Weber
Alfredo Aguirre
Publication date
01-12-2017
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 4/2017
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-017-0815-0

Other articles of this Issue 4/2017

Head and Neck Pathology 4/2017 Go to the issue