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Published in: Head and Neck Pathology 2/2015

01-06-2015 | Case Report

Adamantinoma-Like Ewing Sarcoma Mimicking Basal Cell Adenocarcinoma of the Parotid Gland: A Case Report and Review of the Literature

Authors: Cecilia Lezcano, Martha R. Clarke, Lei Zhang, Cristina R. Antonescu, Raja R. Seethala

Published in: Head and Neck Pathology | Issue 2/2015

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Abstract

Adamantinoma-like Ewing sarcoma (AES) is a rare variant of the Ewing family of tumors that resembles classic adamantinoma of bone. AES shows epithelial differentiation and a more complex immunohistochemical expression profile with keratin and basal marker immunoreactivity and can resemble a variety of carcinomas. We report an unusual case of an AES of the parotid gland that mimicked a basal cell adenocarcinoma. Like basal cell adenocarcinoma, this AES showed a nested basaloid proliferation with peripheral palisading in tumor nests with ‘basaloid’ epithelial differentiation as highlighted by cytokeratin AE1/3 and p40 positivity. However, unlike most basal cell adenocarcinomas, this tumor demonstrated high grade morphology, showed no true ductal or myoepithelial component, and also showed a tendency towards neuroectodermal phenotype with focal rosette formation, CD99 and weak synaptophysin immunoreactivity. EWSR1 and FLI1 fluorescence in situ hybridization confirmed the presence of a translocation supporting the diagnosis of AES. This is the first case of AES presenting as a primary parotid mass highlighting the potential to be mistaken for primary salivary gland carcinomas, which in addition to basal cell adenocarcinoma include other basaloid tumors such as adenoid cystic carcinoma.
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Metadata
Title
Adamantinoma-Like Ewing Sarcoma Mimicking Basal Cell Adenocarcinoma of the Parotid Gland: A Case Report and Review of the Literature
Authors
Cecilia Lezcano
Martha R. Clarke
Lei Zhang
Cristina R. Antonescu
Raja R. Seethala
Publication date
01-06-2015
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 2/2015
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-014-0558-0

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